Biomechanical behaviour of PEDOT:PSS-based hydrogels as an electrode for stent integrated enzyme biofuel cells

Antipova, Christina G.; Parunova, Yulia M.; Vishnevskaya, M. V.; Krasheninnikov, Sergey V.; Луканина, К. И.; Grigoriev, T. E.; Чвалун, С. Н.; Готовцев, П. М.

doi:10.1016/j.heliyon.2022.e09218

Cited by 8 publications

(5 citation statements)

References 55 publications

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“…To create a pH sensor, a protective layer of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) was added over the Mg electrode. The PEDOT:PSS complex offers outstanding biocompatibility and water solubility, making it the perfect candidate for the fabrication of biomedical devices, including implants, due to its ability to sustain cell viability. − Then, a pH-sensitive conductive polymer, polyaniline/poly(vinyl alcohol) (PANI/PVA) composite, was sprayed to form the pH biosensor. By adding PVA, a biodegradable and water-soluble polymer, to PANI, it can be transformed into a biodegradable composite that is suitable for use in biomedical implant applications, as demonstrated in previous research studies. − The sensor’s electrochemical response was tested using open circuit potential (OCP) with various pH solutions from 9 to 5, resulting in the PANI’s resistance changing reversibly due to protonation/deprotonation.…”

Section: Resultsmentioning

confidence: 99%

“…The PEDOT:PSS complex offers outstanding biocompatibility and water solubility, making it the perfect candidate for the fabrication of biomedical devices, including implants, due to its ability to sustain cell viability. 47 − 49 Then, a pH-sensitive conductive polymer, polyaniline/poly(vinyl alcohol) (PANI/PVA) composite, was sprayed to form the pH biosensor. By adding PVA, a biodegradable and water-soluble polymer, to PANI, it can be transformed into a biodegradable composite that is suitable for use in biomedical implant applications, as demonstrated in previous research studies.…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring

Omar,

Saliba,

Khatib

et al. 2024

ACS Sens.

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Cardiac monitoring after heart surgeries is crucial for health maintenance and detecting postoperative complications early. However, current methods like rigid implants have limitations, as they require performing second complex surgeries for removal, increasing infection and inflammation risks, thus prompting research for improved sensing monitoring technologies. Herein, we introduce a nanosensor platform that is biodegradable, biocompatible, and integrated with multifunctions, suitable for use as implants for cardiac monitoring. The device has two electrochemical biosensors for sensing lactic acid and pH as well as a pressure sensor and a chemiresistor array for detecting volatile organic compounds. Its biocompatibility with myocytes has been tested in vitro, and its biodegradability and sensing function have been proven with ex vivo experiments using a three-dimensional (3D)-printed heart model and 3D-printed cardiac tissue patches. Moreover, an artificial intelligence-based predictive model was designed to fuse sensor data for more precise health assessment, making it a suitable candidate for clinical use. This sensing platform promises impactful applications in the realm of cardiac patient care, laying the foundation for advanced life-saving developments.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring

Omar,

Saliba,

Khatib

et al. 2024

ACS Sens.

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“…While PB is widely employed as a very well-working substance with "artificial peroxidase" activity that also participates in electron transfer [46], others can also be used. Examples include carbon-based materials such as CNT, MWCNT, graphene oxide, graphite, and conducting polymers, such as PEDOT:PSS [53,54].…”

Section: Development Of a New Biocathode For A Single-enzyme Biofuel ...mentioning

confidence: 99%

Fueling the Future: The Emergence of Self-Powered Enzymatic Biofuel Cell Biosensors

Gupta,

Krasnoslobodtsev

2024

Biosensors

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Self-powered biosensors are innovative devices that can detect and analyze biological or chemical substances without the need for an external power source. These biosensors can convert energy from the surrounding environment or the analyte itself into electrical signals for sensing and data transmission. The self-powered nature of these biosensors offers several advantages, such as portability, autonomy, and reduced waste generation from disposable batteries. They find applications in various fields, including healthcare, environmental monitoring, food safety, and wearable devices. While self-powered biosensors are a promising technology, there are still challenges to address, such as improving energy efficiency, sensitivity, and stability to make them more practical and widely adopted. This review article focuses on exploring the evolving trends in self-powered biosensor design, outlining potential advantages and limitations. With a focal point on enzymatic biofuel cell power generation, this article describes various sensing mechanisms that employ the analyte as substrate or fuel for the biocatalyst’s ability to generate current. Technical aspects of biofuel cells are also examined. Research and development in the field of self-powered biosensors is ongoing, and this review describes promising areas for further exploration within the field, identifying underexplored areas that could benefit from further investigation.

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“…PEDOT:PSS can also be used in hydrogels used as self-standing MFC bioanodes. In [ 191 ], a three-component electroconductive hydrogel containing polyvinyl alcohol, carrageenan, and PEDOT:PSS became the basis of an EFC electrode integrated into a stent. The high biocompatibility of the obtained material will make it possible to use it as part of BFCs implanted into the cardiovascular system.…”

Section: Bfcs Based On Conductive Polymersmentioning

confidence: 99%

Conductive Polymers and Their Nanocomposites: Application Features in Biosensors and Biofuel Cells

Kuznetsova,

Arlyapov,

Plekhanova

et al. 2023

Polymers

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Conductive polymers and their composites are excellent materials for coupling biological materials and electrodes in bioelectrochemical systems. It is assumed that their relevance and introduction to the field of bioelectrochemical devices will only grow due to their tunable conductivity, easy modification, and biocompatibility. This review analyzes the main trends and trends in the development of the methodology for the application of conductive polymers and their use in biosensors and biofuel elements, as well as describes their future prospects. Approaches to the synthesis of such materials and the peculiarities of obtaining their nanocomposites are presented. Special emphasis is placed on the features of the interfaces of such materials with biological objects.

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Biomechanical behaviour of PEDOT:PSS-based hydrogels as an electrode for stent integrated enzyme biofuel cells

Cited by 8 publications

References 55 publications

Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring

Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring

Fueling the Future: The Emergence of Self-Powered Enzymatic Biofuel Cell Biosensors

Conductive Polymers and Their Nanocomposites: Application Features in Biosensors and Biofuel Cells

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