Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid–Structure Interaction Modelling Approach

Oliveira, Daniel P. S.; Abdullah, Nazirul; Green, Naomi C.; Espino, Daniel M.

doi:10.1007/s13239-020-00469-9

Cited by 11 publications

(12 citation statements)

References 83 publications

(144 reference statements)

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“…Geometric orifice area characterizes the dynamic changes of the physical orifice area of the aortic valve, and the maximum value appeared at the moment when the pressure difference was greatest ( t = 0.05 s). In this study, the maximum GOA of the TAV and BAV models during systole was lower than the GOA reported in similar studies ( Cao and Sucosky, 2017 ; de Oliveira et al, 2020 ), which might be due to the differences in the models. Diameter of the aortic annulus used in this article was 23 mm, which was a smaller annulus size.…”

Section: Discussioncontrasting

confidence: 89%

“…All the FSI processes were completed using explicit solver provided by LS-DYNA R11.1.0 (LSTC, Livermore, CA, United States and ANSYS Inc., Canonsburg, PA, United States). The effectiveness of this software in heart valves problems had been widely confirmed in previous studies ( de Oliveira et al, 2020 ; Luraghi et al, 2020 ). Two cardiac cycles (The duration of single cycle was set to 0.8 s) were considered in the calculation to eliminate the effect of the initial instability.…”

Section: Methodssupporting

confidence: 58%

“…Obvious eccentric jet flow was found in Type 1 and Type 2 BAV models, which made a strong impact on the ascending aortic wall. The long-term effect of the high-speed eccentric jet on the ascending aorta may be an important reason for its expansion ( Cao et al, 2017 ; Liu et al, 2018 ; de Oliveira et al, 2020 ). Although the flow profile of Type 0 was roughly centrosymmetric, the long narrow jet at both ends of the cross-section would also generate higher local stress on the ascending aorta.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the left ventricular pressure of BAV patients may be higher than healthy people with normal TAV, which is different from our assumption. In other similar studies, common flow condition was used in the left ventricular inlet ( de Oliveira et al, 2020 ), ignoring the influence of BAV malformation on CO, which also deviated from the actual physiological situation. In our study, we used the pressure value and waveform corresponding to the healthy TAV as the inlet pressure of the BAV model, with the purpose of comparing the CO provided by BAV models under the same left ventricular work.…”

Section: Discussionmentioning

confidence: 99%

“…Compared with the non-dilated aorta, abnormal hemodynamics would also appear in the dilated aorta, which could be demonstrated by the characteristics of blood flow and reginal WSS. de Oliveira et al (2020) studied the hemodynamics and leaflet mechanical properties of TAV and all phenotypes of BAV (Type 0, Type 1, and Type 2) only in the systole period. The results showed that Type 0 produced the best hemodynamics and mechanical properties, and the raphe of Type 1 changed the position of abnormal hemodynamic characteristics, while Type 2 inhibited the development of blood flow, and the leaflet stress and hemodynamic parameters were the worst.…”

Section: Introductionmentioning

confidence: 99%

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A Fluid–Structure Interaction Study of Different Bicuspid Aortic Valve Phenotypes Throughout the Cardiac Cycle

Yan

Wang

et al. 2021

Front. Physiol.

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The bicuspid aortic valve (BAV) is a congenital malformation of the aortic valve with a variety of structural features. The current research on BAV mainly focuses on the systolic phase, while ignoring the diastolic hemodynamic characteristics and valve mechanics. The purpose of this study is to compare the differences in hemodynamics and mechanical properties of BAV with different phenotypes throughout the cardiac cycle by means of numerical simulation. Based on physiological anatomy, we established an idealized tricuspid aortic valve (TAV) model and six phenotypes of BAV models (including Type 0 a–p, Type 0 lat, Type 1 L–R, Type 1 N-L, Type 1 R-N, and Type 2), and simulated the dynamic changes of the aortic valve during the cardiac cycle using the fluid–structure interaction method. The morphology of the leaflets, hemodynamic parameters, flow patterns, and strain were analyzed. Compared with TAV, the cardiac output and effective orifice area of different BAV phenotypes decreased certain degree, along with the peak velocity and mean pressure difference increased both. Among all BAV models, Type 2 exhibited the worst hemodynamic performance. During the systole, obvious asymmetric flow field was observed in BAV aorta, which was related to the orientation of BAV. Higher strain was generated in diastole for BAV models. The findings of this study suggests specific differences in the hemodynamic characteristics and valve mechanics of different BAV phenotypes, including different severity of stenosis, flow patterns, and leaflet strain, which may be critical for prediction of other subsequent aortic diseases and differential treatment strategy for certain BAV phenotype.

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Section: Discussioncontrasting

confidence: 89%

Section: Methodssupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Fluid–Structure Interaction Study of Different Bicuspid Aortic Valve Phenotypes Throughout the Cardiac Cycle

Yan

Wang

et al. 2021

Front. Physiol.

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Three‐dimensional fluid–structure interaction simulation of the Wheatley aortic valve

Oliveira,

Buscaglia,

Paz

et al. 2023

Numer Methods Biomed Eng

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Valvular heart diseases (such as stenosis and regurgitation) are recognized as a rapidly growing cause of global deaths and major contributors to disability. The most effective treatment for these pathologies is the replacement of the natural valve with a prosthetic one. Our work considers an innovative design for prosthetic aortic valves that combines the reliability and durability of artificial valves with the flexibility of tissue valves. It consists of a rigid support and three polymer leaflets which can be cut from an extruded flat sheet, and is referred to hereafter as the Wheatley aortic valve (WAV). As a first step towards the understanding of the mechanical behavior of the WAV, we report here on the implementation of a numerical model built with the ICFD multi‐physics solver of the LS‐DYNA software. The model is calibrated and validated using data from a basic pulsatile‐flow experiment in a water‐filled straight tube. Sensitivity to model parameters (contact parameters, mesh size, etc.) and to design parameters (height, material constants) is studied. The numerical data allow us to describe the leaflet motion and the liquid flow in great detail, and to investigate the possible failure modes in cases of unfavorable operational conditions (in particular, if the leaflet height is inadequate). In future work the numerical model developed here will be used to assess the thrombogenic properties of the valve under physiological conditions.

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Fluid–structure interaction modeling of compliant aortic valves using the lattice Boltzmann CFD and FEM methods

Morany

Lavon

Bardón³

et al. 2023

Biomech Model Mechanobiol

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Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid–Structure Interaction Modelling Approach

Abstract: assessment of bicuspid aortic valve phenotypes: a fluid-structure interaction modelling approach', Cardiovascular Engineering and Technology.

Cited by 11 publications

References 83 publications

A Fluid–Structure Interaction Study of Different Bicuspid Aortic Valve Phenotypes Throughout the Cardiac Cycle

A Fluid–Structure Interaction Study of Different Bicuspid Aortic Valve Phenotypes Throughout the Cardiac Cycle

Three‐dimensional fluid–structure interaction simulation of the Wheatley aortic valve

Fluid–structure interaction modeling of compliant aortic valves using the lattice Boltzmann CFD and FEM methods

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