Biomechanical and biochemical investigation of erythrocytes in late stage human leptospirosis

Silva, J.A.X.; Albertini, A.V.P.; Fonseca, Caíque Silveira Martins da; Silva, D.C.N.; Carvalho, Vera C. O.; Lima, Vera Lúcia de Menezes; Fontes, Adriana; Costa, Edbhergue Ventura Lola; Nogueira, Rejane Jurema Mansur Custódio

doi:10.1590/1414-431x20209268

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Furthermore, machine perfusion driven viability assessment during HMP/HOPE or NMP may support clinical decision in the acceptance or rejection of marginal liver allografts [ 4 , 6 , 184 ]. Besides refinement of the preservation techniques, the impact of hepatic dysfunction on macro- and micro-rheological parameters still need to be investigated, including metabolomics studies, to reveal better the local and systemic effects [ 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 ]. However, it would be interesting to overview it in a separate paper.…”

Section: Future Perspectives and Remaining Challengesmentioning

confidence: 99%

Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

Németh

Pető

Magyar

et al. 2021

IJMS

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Hepatic ischemia-reperfusion injury (IRI) is a multifactorial phenomenon which has been associated with adverse clinical outcomes. IRI related tissue damage is characterized by various chronological events depending on the experimental model or clinical setting. Despite the fact that IRI research has been in the spotlight of scientific interest for over three decades with a significant and continuous increase in publication activity over the years and the large number of pharmacological and surgical therapeutic attempts introduced, not many of these strategies have made their way into everyday clinical practice. Furthermore, the pathomechanism of hepatic IRI has not been fully elucidated yet. In the complex process of the IRI, flow properties of blood are not neglectable. Hemorheological factors play an important role in determining tissue perfusion and orchestrating mechanical shear stress-dependent endothelial functions. Antioxidant and anti-inflammatory agents, ischemic conditioning protocols, dynamic organ preservation techniques may improve rheological properties of the post-reperfusion hepatic blood flow and target endothelial cells, exerting a potent protection against hepatic IRI. In this review paper we give a comprehensive overview of microcirculatory, rheological and molecular–pathophysiological aspects of hepatic circulation in the context of IRI and hepatoprotective approaches.

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Section: Future Perspectives and Remaining Challengesmentioning

confidence: 99%

Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

Németh

Pető

Magyar

et al. 2021

IJMS

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Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy

Konaklieva,

Plotkin

2024

Front. Mol. Biosci.

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Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging strategy of anti-infective therapy, which targets host cell metabolism utilized by facultative and obligate intracellular pathogens for entry, replication, egress or persistence of infected host cells. This review provides an overview of the host lipid metabolism and links it to the challenges in the development of HDTs for viral and bacterial infections, where pathogens are using important for the host lipid enzymes, or producing their own analogous of lecithin-cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) thus interfering with the human host’s lipid metabolism.

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Biomechanical and biochemical investigation of erythrocytes in late stage human leptospirosis

Cited by 2 publications

References 34 publications

Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy

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