Biomaterials With Enhanced Biological Functions for Medical Applications

Balint, Reka; Paltinean, Gertrud Alexandra; Tomoaia, Gheorghe; OLTEAN-DAN, Daniel; Mocanu, Aurora; Tomoaia-Cotişel, Maria

doi:10.56082/annalsarscibio.2021.1.90

Cited by 1 publication

(2 citation statements)

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“…They adhere to the surface of the biomimetic composite, increasing the biocompatibility of the entire coating surface on the Ti implant. This method aims to achieve complex deposition layers that combine HAP nanoparticles with biocompatible binding components such as collagen [95][96][97][98][99].…”

Section: Physical and Chemical Characterization Of Biomimetic Coating...mentioning

confidence: 99%

“…The volume of interest (VOI) was set at 2 mm below the growth plate with a 1 mm in height and a 1.5 mm diameter ring around the implant, after which the percentage of bone volume (BV/TV) and the average trabecular number (Tb.N) in the volume of interest were determined (see, Table 2). The biocompatibility of uncovered and coated Ti implants and their osseointegration at the fracture level were evaluated using light microscopy, on tissue samples stained with hematoxylin and eosin (H&E) from each of the two groups of animals studied, at eight-weeks postoperatively [98,99,112].…”

Section: Studies Of Orthopedic (Medical) Implants In Vivomentioning

confidence: 99%

See 1 more Smart Citation

Advanced Nanomaterials and Coated Surfaces for Orthopedic Implants – A Review

Balint¹,

Mocanu²,

Tomoaia³

et al. 2021

AnnalsARSciPhysChem

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Critical-sized defects in bone induced by trauma have in numerous presented cases difficult challenges to the current treatment for bone repair. The main purpose of bone tissue engineered scaffolds is to use advanced materials to promote the natural healing process of bone which does not easily occur in critical-sized defects or on metallic implants. A synthetic bone scaffold and a coating on Ti implants must be biocompatible and biodegradable to allow the native tissue integration, and mimic the chemical composition and structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold and the coating layers on metallic implants must be capable of releasing essential physiologic elements, like Mg, Zn, Sr and Si, and also containing bioactive molecules (e.g., collagen, COL) to accelerate extracellular matrix production and tissue integration. Also, these advanced materials might be doped with drugs (e.g., antibiotics, such as vancomycin) to prevent undesired biological response such as infections, especially with Staphylococcus aureus, S. aureus. Various biomaterials include hydroxyapatite (HAP) ceramics or multifunctional hydroxyapatite substituted with Mg, Zn, Sr and Si, mf-HAP, polymers, such as poly lactic acid (PLA, approved for medical applications by Food and Drug Administration, US FDA, and collagen, or their mixtures as biomimetic composites which have been investigated for their potential as bone scaffold materials and coatings on metallic implants. This article briefly reviews the physical and chemical characteristics of used advanced materials and describes the key-technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an over view of local drug delivery as it pertains to bone tissue engineering.

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