Biomaterials Used for Periodontal Disease Treatment: Focusing on Immunomodulatory Properties

Garzón, Hernan; Suárez, Lina J; Muñoz, S.; Cardona, Julián Andrés Tamayo; Fontalvo, M.; Alfonso, Camilo

doi:10.1155/2022/7693793

Cited by 5 publications

(2 citation statements)

References 86 publications

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“…to promote tissue regeneration. Periodontal tissue regeneration is one biomedical field that can benefit from the specific properties and versatility of microparticle delivery systems [36,38].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Chitosan-Based 0.5% Tetracycline Gel and Freeze-Dried Platelet-Rich Plasma on Post-Periodontal Surgery Healing: Clinical and Immunohistochemical Evaluation

SIMANJUNTAK,

WULANDARI,

SATRIA

et al. 2024

Int J App Pharm

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Objective: Periodontal treatment widely uses tetracycline as a local antibiotic because it has broad-spectrum antibacterial and anticollagenase properties. Chitosan-based 0.5% tetracycline gel, there was an increase in the performance of tetracycline because chitosan released the drug locally, was slower, controlled, lasted longer, had better stability and lower toxicity. Periodontal treatment is currently trending using Platelet-Rich Plasma (PRP) because of its properties, which release many growth factors. To facilitate clinical administration, PRP was developed by the freeze-drying process to become allogeneic Freeze Dried PRP (FD-PRP) obtained from the blood bank. Combination can help accelerate the healing of periodontal surgical wounds. To evaluate the effectiveness of administration of chitosan-based 0.5% tetracycline gel and FD-PRP. Methods: Laboratory experimental study with posttest-only control group design on 30 Wistars-induced periodontitis. The sample was divided into 5 groups: negative and positive control group and 3 periodontal surgical intervention groups accompanied by drug administration. The examination of clinical parameters such as Bleeding on Probing (BoP) and Pocket Depth (PD) as well as immunohistochemical parameters such as fibroblast growth factor-2 (FGF-2) were evaluated on days 3 and 14. Results: This study showed a significant decrease in BoP on day 3 (p=0.022) and 14 (p=0.009), decrease in PD on day 14 (p=0.007) and a significant increase in FGF-2 on day 3 (p=0.024) and decrease on day 14 (p=0.017). Conclusion: Administration of chitosan-based 0.5% tetracycline gel and FD-PRP were effective in periodontal surgical wound healing because it reduced BoP and PD and increased fibroblast cell proliferation through increasing FGF-2 expression.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Chitosan-Based 0.5% Tetracycline Gel and Freeze-Dried Platelet-Rich Plasma on Post-Periodontal Surgery Healing: Clinical and Immunohistochemical Evaluation

SIMANJUNTAK,

WULANDARI,

SATRIA

et al. 2024

Int J App Pharm

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“…The roles of biomaterials in immunomodulation in ocular therapy can be classified as follows. The first approach is to use biomaterials to construct carriers of therapeutic agents while the biomaterial itself is intended to passively and inertly affect the immune response (Garzón et al, 2022). The second approach is similar but more intriguing.…”

Section: Introductionmentioning

confidence: 99%

Roles of biomaterials in modulating the innate immune response in ocular therapy

Rafiei

Chung²,

Chau³

2023

Front. Drug Deliv.

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The eye is a hard-to-treat organ due to its poor regenerative capacity and susceptibility to inflammation; as a result, it has an immune privilege mechanism. In the case of ocular degenerative disorders, chronic and uncontrolled ocular inflammations can overcome this immune response to initiate and exacerbate tissue degeneration, ultimately leading to blindness. Recent landmark discoveries on the key roles of the ocular innate immune system in regulating acute and chronic inflammations as well as tissue fibrosis and homeostasis have shed light on the value of novel treatment interventions in modulating ocular immune responses at the molecular, cellular, and tissue levels. This strategy can be attained by using therapeutics to target resident phagocytes and antigen-presenting cells, namely, microglia and dendritic cells, as well as infiltrating neutrophils and macrophages. Biomaterials are foreign materials to the host and interact with innate immune cells. To leverage such intrinsic immunomodulatory properties, biomaterials such as implants, injectable depots, and nano/micro particles can be used alone as a treatment or with different payloads as carriers in immune-related ocular disorders. This article discusses how physicochemical properties such as biodegradability, size, shape, and charge affect biomaterials’ interaction with the eye’s innate immune system, therefore influencing outcomes towards pro- or anti-inflammatory responses. Knowledge about the eye’s immunological response is required for designing tolerogenic biomaterials including intraocular lenses, cellular scaffolds, therapeutic molecule depots, or carriers of gene therapies. The discussion presented in this review will shed light on the potential use of biomaterials to direct immune responses toward favorable treatment outcomes.

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In-vitro antibiofilm activity of polycaprolactone- poly (lactic-co-glycolic acid) nanofibers loaded amphotericin B, antimicrobial peptide LfcinB (21–25)Pal and zinc oxide for local treatment of periodontitis associated with obstructive sleep apnea

Téllez Corral,

Villamil Poveda,

Roa Molina

et al. 2024

Journal of Drug Delivery Science and Technology

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Biomaterials Used for Periodontal Disease Treatment: Focusing on Immunomodulatory Properties

Cited by 5 publications

References 86 publications

Effectiveness of Chitosan-Based 0.5% Tetracycline Gel and Freeze-Dried Platelet-Rich Plasma on Post-Periodontal Surgery Healing: Clinical and Immunohistochemical Evaluation

Effectiveness of Chitosan-Based 0.5% Tetracycline Gel and Freeze-Dried Platelet-Rich Plasma on Post-Periodontal Surgery Healing: Clinical and Immunohistochemical Evaluation

Roles of biomaterials in modulating the innate immune response in ocular therapy

In-vitro antibiofilm activity of polycaprolactone- poly (lactic-co-glycolic acid) nanofibers loaded amphotericin B, antimicrobial peptide LfcinB (21–25)Pal and zinc oxide for local treatment of periodontitis associated with obstructive sleep apnea

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