Biomaterials Regulating Bone Hematoma for Osteogenesis

Yang, Ying; Xiao, Yin

doi:10.1002/adhm.202000726

Cited by 38 publications

(28 citation statements)

References 132 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 1 – 3 Over the past few decades, biomaterials and interface tissue engineering fields have made considerable progress in suggesting promising strategies to stimulate tissue regeneration after bone tissue damage and/or loss caused by trauma, pathology, and resorption. 4 – 6 Traditionally, titanium alloys (known as bio-inert metallic implants) are considered the gold standard for stabilizing bone fractures. 7 Compared to other implants such as stainless steel, titanium alloys are developed as promising bone implants due to their good biocompatibility, corrosion resistance, and closer modulus to bone.…”

Section: Introductionmentioning

confidence: 99%

Early osteoimmunomodulatory effects of magnesium–calcium–zinc alloys

et al. 2021

View full text Add to dashboard Cite

Today, substantial attention is given to biomaterial strategies for bone regeneration, and among them, there is a growing interest in using immunomodulatory biomaterials. The ability of a biomaterial to induce neo vascularization and macrophage polarization is a major factor in defining its success. Magnesium (Mg)-based degradable alloys have attracted significant attention for bone regeneration owing to their biodegradability and potential for avoiding secondary removal surgeries. However, there is insufficient evidence in the literature regarding the early inflammatory responses to these alloys in vivo. In this study, we investigated the early body responses to Mg-0.45wt%Zn-0.45wt%Ca pin-shaped alloy (known as ZX00 alloy) in rat femora 2, 5, and 10 days after implantation. We used 3D micro computed tomography (µCT), histological, immunohistochemical, histomorphometrical, and small angle X-ray scattering (SAXS) analyses to study new bone formation, early macrophage polarization, neo vascularization, and bone quality at the implant bone interface. The expression of macrophage type 2 biological markers increased significantly after 10 days of Mg alloy implantation, indicating its potential in stimulating macrophage polarization. Our biomineralization results using µCT as well as histological stained sections did not indicate any statistically significant differences between different time points for both groups. The activity of alkaline phosphatase (ALP) and Runt-related transcription factor 2 (Runx 2) biological markers decreased significantly for Mg group, indicating less osteoblast activity. Generally, our results supported the potential of ZX00 alloy to enhance the expression of macrophage polarization in vivo; however, we could not observe any statistically significant changes regarding biomineralization.

show abstract

Section: Introductionmentioning

confidence: 99%

Early osteoimmunomodulatory effects of magnesium–calcium–zinc alloys

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Indeed, the modulation of cellular adhesion is important for the control of recruitment in the early stage osteogenic differentiation of stem cells [126]. However, most man-made biomaterials lack favorable surfaces for cell attachment owing to missing specific cell-recognizable signals, such as adhesive ligands for integrins [127][128][129].…”

Section: Role Of Biomaterials In the Regulation Of Msc Behaviormentioning

confidence: 99%

“…However, most man-made biomaterials lack favorable surfaces for cell attachment owing to missing specific cell-recognizable signals, such as adhesive ligands for integrins [127][128][129]. Additionally, chemical composition and surface properties greatly affect the regulation of protein adsorption and subsequent cell attachment and differentiation [126,130,131]. erefore, surface functionalization of implant materials has emerged as a promising method to obtain an interface with enhanced bioactivity between implants and tissues [127,132].…”

Section: Role Of Biomaterials In the Regulation Of Msc Behaviormentioning

confidence: 99%

Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration

Gong

Groth

et al. 2021

Advances in Materials Science and Engineering

View full text Add to dashboard Cite

Impaired bone healing caused by severe trauma, infection, and tumor resection is an extremely common phenomenon. Therefore, the treatment of bone defects represents a major clinical challenge worldwide. In such situations, the application of biomaterials is necessary for filling defects and promoting bone regeneration. Bone repair biomaterials having osteoconductive and osteoinductive properties can act as an appropriate template for the formation of new bone and induce the osteogenic differentiation of preosteocytes and stem cells. Thus, the influence of biomaterials on the regulation of osteogenesis of mesenchymal stem cells (MSCs) has been widely studied. However, immune response is also critical in bone healing; macrophages play pivotal and dynamic roles in bone regeneration. The interfacial properties of biomaterials that affect the adsorption of proteins and the adhesion function of cells require great attention in the field of bone tissue engineering because they are related to the crosstalk with the immune and bone or stem cells. Thus, selection of biomaterials or specific surface coatings may reduce local undesirable inflammatory responses and promote bone regeneration. This review provides a detailed overview of bone regeneration mechanisms and the interaction between immune cells and MSCs. Moreover, the influence of biomaterials on the regulation of functions of MSCs and macrophages and the macrophage-related inflammatory response triggered by biomaterials and its specific role in osteogenesis are discussed.

show abstract

“…Гематома представляє собою мережу фібринових ниток у сукупності з клітинами крові, що забезпечує не лише зупинку кровотечі, а й сприяє остеорепарації через формування її первинної фібриноретикулярної матриці (Yang & Xiao, 2020). Інфільтрація гематоми ендотеліальними клітинами та фібробластами з утворенням нових капілярів та синтезом матричного колагену зрештою приводить до утворення, так званої, кісткової грануляційної тканини, яка заміщує кров'яний згусток міжвідламкового простору (Ho- Shui-Ling et al, 2018).…”

Section: вступunclassified

“…Після видалення гематоми з ділянки кісткової травми відбувається зниження репаративного потенціалу, і, навпаки, при її трансплантації у місце перелому відбувається швидше відновлення травмованої ділянки (Ho-Shui-Ling et al, 2018;Yang & Xiao, 2020).…”

Section: результати та їх обговоренняunclassified

Histomorphological characteristics of bone replacement in rabbits with hydroxyapatite ceramics and Platelet-Rich Fibrin

et al. 2021

View full text Add to dashboard Cite

The results of a histomorphological study of bone regenerates in rabbits after osteosubstitution with platelet-rich fibrin and its combination with hydroxyapatite granules with β-tricalcium phosphate in spongy and compact bone tissue at different periods of reparative osteogenesis are presented. Three groups of rabbits were formed. In the control group, the defects were left to heal under the blood clot. Bone lesions in the first experimental group were filled with platelet-rich fibrin, in the second – with a combination of platelet-rich fibrin and hydroxyapatite with β-tricalcium phosphate. All animals were kept in the same conditions of feeding and housing, had unlimited access to water. During the study, the rabbits were monitored clinically. The animals were taken out of the experiment on the 14th, 21st and 42nd days, samples of bone tissue were taken, they were fixed, decalcified, dehydrated in alcohols of increasing concentration and embedded in paraffin. In the presented study, it is most likely that the newly formed bone tissue is formed precisely due to osteoinduction in the experimental groups. When using granules of hydroxyapatite and β-tricalcium phosphate with platelet-rich fibrin, bone regenerate is between the composite granules and is not associated with contact with the maternal bone. Its cells appear in different places of the defect. In the spongy bone tissue on the 21st day, regeneration proceeded more fully and faster in the second experimental group, as evidenced by the significant density of cells of the osteoblastic row, the thickness of the bone trabeculae and their volume, filling the site of the defect. On the 42nd day, in the second experimental group, when using a combination of autobiomaterial and hydroxyapatite granules with β-tricalcium phosphate, the regenerate contained a significantly larger number of osteogenic cells in the thickness of the trabeculae, which indicated a more intensive course of reparative osteogenesis in comparison with the first experimental and control groups. In the compact bone on day 21, regeneration was more complete and faster in the second experimental group. On the 42nd day, according to the degree of maturity of the bone regenerate, calcium-phosphate ceramics in combination with platelet-rich fibrin optimizes reparative osteogenesis most clearly. According to the degree of intensity of the osteoregeneration process, the groups can be placed in the following sequence: control ˂PRF˂PRF+HA/β-TCP–700. According to histomorphological characteristics, the combination of hydroxyapatite with β-tricalcium phosphate and platelet-rich fibrin gives greater osteoinduction to the composite material, which is confirmed by the high cell density, namely of osteoblasts and osteocytes. The use of PRF in combination with other materials may become promising for the correction of reparative osteogenesis in conditions of limited or reduced regenerative potential of bone tissue.

show abstract

Biomaterials Regulating Bone Hematoma for Osteogenesis

Cited by 38 publications

References 132 publications

Early osteoimmunomodulatory effects of magnesium–calcium–zinc alloys

Early osteoimmunomodulatory effects of magnesium–calcium–zinc alloys

Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration

Histomorphological characteristics of bone replacement in rabbits with hydroxyapatite ceramics and Platelet-Rich Fibrin

Contact Info

Product

Resources

About