Biomaterials of PVA and PVP in medical and pharmaceutical applications: Perspectives and challenges

Interaction of fibroblasts and induced pluripotent stem cells with poly(vinyl alcohol)‐based hydrogel substrates

“…PVA is a biocompatible and nontoxic polymer that has innumerous applications as a biomaterial (Gao et al, ; Gupta et al, ; Khorasani, Joorabloo, Adeli, Mansoori‐Moghadam, & Moghaddam, ; Liu et al, ; Teodorescu et al, ). Due to its excellent film‐forming properties and hydrophilic feature, PVA has been used as component of tissue engineering scaffolds in order to provide suitable strength and adhesive properties to support cell growth (Gupta et al, ; Liu et al, ; Rodríguez‐Rodríguez, García‐Carvajal, Jiménez‐Palomar, Jiménez‐Avalos, & Espinosa‐Andrews, ; Teodorescu et al, ). Although its hydrophilic nature shows several advantages for cell culture, it is also challenging to avoid rapid dissolution of PVA‐based materials in aqueous media while maintaining suitable culture conditions.…”

“…PVA is a biocompatible and nontoxic polymer that has innumerous applications as a biomaterial (Gao et al, 2019;Gupta et al, 2011;Khorasani, Joorabloo, Adeli, Mansoori-Moghadam, & Moghaddam, 2019;Liu et al, 2009;Teodorescu et al, 2019). Due to its excellent film-forming properties and hydrophilic feature, PVA has been used as the free OH groups of the polymer, giving rise to ester linkages (Harifi & Montazer, 2012).…”

“…Structurally, they may be composed of macro, micro, or nanopores, which enable cell mobility and differentiation (Higuchi, Ling, Chang, Hsu, & Umezawa, ; Kretlow & Mikos, ; Shoichet, ). Particularly, poly(vinyl alcohol) (PVA) is a promising material as a scaffold for tissue engineering as it is nontoxic (Gupta, Webster, & Sinha, ; Liu, Vrana, Cahill, & McGuinness, ; Teodorescu, Bercea, & Morariu, ). Moreover, its mechanical properties can be tuned to obtain hydrogels for specific needs of each cell type (Drozdova et al, ; Gupta et al, ; Muduli et al, ).…”

“…component of tissue engineering scaffolds in order to provide suitable strength and adhesive properties to support cell growth(Gupta et al, 2011;Liu et al, 2009;Rodríguez-Rodríguez, García-Carvajal, Jiménez- Palomar, Jiménez-Avalos, & Espinosa-Andrews, 2019;Teodorescu et al, 2019). Although its hydrophilic nature shows several advantages for cell culture, it is also challenging to avoid rapid dissolution of PVAbased materials in aqueous media while maintaining suitable culture conditions.…”

Poly(vinyl alcohol) triggers Au nanoparticles formation for near‐infrared radiation‐responsive gels and nanofibers

“…A wide range of varieties can be found in the market having different degree of hydrolysis and molecular weight; these two properties notably determine PVA physical and chemical properties . Excellent biocompatibility, chemical inertness, sunlight stability, water solubility, low protein absorption, and easy processability make PVA a common component of drug formulations and medical devices . In addition, the long carbon chains with pendant hydroxyl groups endow PVA with peculiar optical properties, large dielectric strength, and remarkable charge storage ability, which result useful in a variety of technological fields.…”