Biomaterials from the sea: Future building blocks for biomedical applications

Wan, Mei chen; Qin, Wen; Chen, Lei; Li, Qi hong; Meng, Meng; Fang, Ming; Song, Wen; Chen, Ji Hua; Tay, Franklin R.; Niu, Li Na

doi:10.1016/j.bioactmat.2021.04.028

Cited by 88 publications

(37 citation statements)

References 397 publications

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“…Along with the repaid progress of tissue engineering normal biomaterial with biological functions and tunable physical properties are in high demand [ 38 ]. On the one hand, natural polysaccharides from the ocean have been widely developed [ 39 – 41 ]. On the other hand, polymers from Chinese medicine herbs, despite the evidence of bioactivity, still have much room for development, key obstacles include unclear composition and difficulties for material fabrication [ 42 – 44 ].…”

Section: Discussionmentioning

confidence: 99%

Bletilla striata polysaccharide cryogel scaffold for spatial control of foreign-body reaction

et al. 2021

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Background Implantation of a biomaterial may induce the foreign-body reaction to the host tissue that determines the outcome of the integration and the biological performance of the implants. The foreign-body reaction can be modulated by control of the material properties of the implants. Methods First, we synthesized methacrylated Bletilla striata Polysaccharide (BSP-MA) and constructed a series of open porous cryogels utilizing this material via the freezing-thawing treatment of solvent-precursors systems. Second, Pore size and modulus were measured to characterize the properties of BSP cryogels. Live/dead staining of cells and CCK-8 were performed to test the cytocompatibility of the scaffolds. In addition, the Real-Time qPCR experiments were carried for the tests. Finally, the BSP scaffolds were implanted subcutaneously to verify the foreign-body reaction between host tissue and materials. Results Our data demonstrated that cryogels with different pore sizes and modulus can be fabricated by just adjusting the concentration. Besides, the cryogels showed well cytocompatibility in the in vitro experiments and exhibited upregulated expression levels of pro-inflammation-related genes (Tnfa and Il1b) with the increase of pore size. In vivo experiments further proved that with the increase of pore size, more immune cells infiltrated into the inner zone of materials. The foreign-body reaction and the distribution of immune-regulatory cells could be modulated by tuning the material microstructure. Conclusions Collectively, our findings revealed Bletilla striata polysaccharide cryogel scaffold with different pore sizes can spatially control foreign-body reaction. The microstructure of cryogels could differentially guide the distribution of inflammatory cells, affect the formation of blood vessels and fibrous capsules, which eventually influence the material-tissue integration. This work demonstrates a practical strategy to regulate foreign body reaction and promote the performance of medical devices.

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Section: Discussionmentioning

confidence: 99%

Bletilla striata polysaccharide cryogel scaffold for spatial control of foreign-body reaction

et al. 2021

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“…[ 5 , 9 ]; and pure collagen products have poor mechanical properties and rapid degradation in the body, plus the lack of uniform production quality standards, inspection standards, etc. The development of marine-derived biomedical materials is restricted [ 10 , 11 ]. How to obtain high-quality, high-performance clinical products using the aspects of source control, molecular structure adjustment, extraction process improvement, and molecular modification, and expand their clinical application range, has become a hot research topic.…”

Section: Introductionmentioning

confidence: 99%

Three Polymers from the Sea: Unique Structures, Directional Modifications, and Medical Applications

Wang

Qin

2021

Polymers

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With the increase of wounds and body damage, the clinical demand for antibacterial, hemostatic, and repairable biomaterials is increasing. Various types of biomedical materials have become research hotspots. Of these, and among materials derived from marine organisms, the research and application of alginate, chitosan, and collagen are the most common. Chitosan is mainly used as a hemostatic material in clinical applications, but due to problems such as the poor mechanical strength of a single component, the general antibacterial ability, and fast degradation speed research into the extraction process and modification mainly focuses on the improvement of the above-mentioned ability. Similarly, the research and modification of sodium alginate, used as a material for hemostasis and the repair of wounds, is mainly focused on the improvement of cell adhesion, hydrophilicity, degradation speed, mechanical properties, etc.; therefore, there are fewer marine biological collagen products. The research mainly focuses on immunogenicity removal and mechanical performance improvement. This article summarizes the source, molecular structure, and characteristics of alginate, chitosan, and collagen from marine organisms; and introduces the biological safety, clinical efficacy, and mechanism of action of these materials, as well as their extraction processes and material properties. Their modification and other issues are also discussed, and their potential clinical applications are examined.

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“…The world market for skincare products was valued at USD 38.3 billion globally in 2005 [5]. Marine-derived materials based on marine biosources have been used as raw materials for bioengineering or as basic elements for research and biomimetic products [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite (HAp) is the most important bioceramic material for bone TE due to extremely important properties such as biocompatibility, bioactivity and stability, biological properties necessary for rapid bone regeneration [7,8,[65][66][67]. HAp has several marine biological sources, such as cuttlefish bone [68], corals [69], fish bones [70,71] and shells [72,73], which provide cheap raw materials.…”

Section: Introductionmentioning

confidence: 99%

Microwave Technology Using Low Energy Concentrated Beam for Processing of Solid Waste Materials from Rapana thomasiana Seashells

et al. 2021

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The solid waste of Rapana thomasiana seashells both from domestic activities and natural waste on seashore can be used to obtain viable products for medical applications. However, conventional technologies applied for sintering the materials require massive energy consumption due to the resistance heating. Microwave heating represents an advanced technology for sintering, but the stability of the process, in terms of thermal runaway and microwave plasma arc discharge, jeopardizes the quality of the sintered products. This paper aims to present the results of research focused on viable heating technology and the mechanical properties of the final products. A comparative analysis, in terms of energy efficiency vs. mechanical properties, has been performed for three different heating technologies: direct microwave heating, hybrid microwave heating and resistance heating. The results obtained concluded that the hybrid microwave heating led to final products from Rapana thomasiana solid waste with similar mechanical properties compared with resistance heating. In terms of energy efficiency, the hybrid microwave heating was 20 times better than resistance heating.

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Biomaterials from the sea: Future building blocks for biomedical applications

Cited by 88 publications

References 397 publications

Bletilla striata polysaccharide cryogel scaffold for spatial control of foreign-body reaction

Bletilla striata polysaccharide cryogel scaffold for spatial control of foreign-body reaction

Three Polymers from the Sea: Unique Structures, Directional Modifications, and Medical Applications

Microwave Technology Using Low Energy Concentrated Beam for Processing of Solid Waste Materials from Rapana thomasiana Seashells

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