Biomaterials from Chitosan Processed by Electrospinning

Bossard, Frédéric; Rinaudo, Marguerite

doi:10.17756/nwj.2019-069

Cited by 5 publications

(5 citation statements)

References 25 publications

(25 reference statements)

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“…Nanofibers made of chitosan as reference [14][15][16][17] and CS/ HA PEC have been processed by electrospinning in presence of PEO to favor spinnability. The samples are characterized as spun and after stabilization allowing to extract PEO and excess of salts and solvents in Ethanol (EtOH)/water 80/20 v/v.…”

Section: Resultsmentioning

confidence: 99%

Novel Nanofibers Made of Chitosan/Hyaluronan Electrostatic Complex

García¹,

Bossard²,

Rinaudo³

2021

NanoWorld J

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After preparation of pure chitosan nanofibers, development of electrospinning in our laboratory allowed to prepare new nanofibers made of hyaluronan (HA) and chitosan (CS) polyelectrolyte complex (PEC). It is the first time that such materials are produced taking advantage of the properties of these two important biological polymers. PEC fibers need to be stabilized by thermal treatment to enable their use as materials for biological applications. Spinnability of the blends and some physicochemical properties were evaluated as well as their mechanical properties under different fiber arrangement. Finally, the fibers were applied for chondrocyte development in view of tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Novel Nanofibers Made of Chitosan/Hyaluronan Electrostatic Complex

García¹,

Bossard²,

Rinaudo³

2021

NanoWorld J

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“…To compare fiber deposition on selected collectors, square patterned collector and rotary cylinder were utilized for electrospinning of the blend CS/PEO. The process was carried out under the conditions already described [1,5,6] and the mats produced are shown in figure 2.…”

Section: Influence Of Collector Structurementioning

confidence: 99%

“…Native ECMs can be effectively mimicked by electrospun nanofiber membranes, specially using natural sourced polymers. In previous work, chitosan (CS)-based systems (CS and electrostatic complex CS/ hyaluronan HA) were transformed, by electrospinning, into biocompatible and biodegradable nanofibrous mats adapted for chondrocyte development [1][2][3][4]. CS materials are claimed to favor cell adhesion and growth, providing the adequate microenvironment for chondrocyte phenotype preservation.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Chitosan Nanofibers used for Chondrocyte Development: Influence of the Structure of Fibrillar Support

2022

NanoWorld J

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This paper describes the development of our work on electrospinning of chitosan (CS) to get pure chitosan nanofiber mats proposed as support for chondrocyte culture. Electrospinning is carried out in presence of PEO as aid, and dissolution of CS and PEO in formic acid/water mixture. The fibers were recovered using different structured collectors to evidence their role on the mat structure and advantage for cell development. Rotary cylinder, at different rotation rates, allows to align the fibers and increases their crystallinity and anisotropic mechanical performances. Square-patterned collector gives a more porous material with more cells attached. The cells fixed on nanofibers have their normal round-type morphology, contrary to the elongated structure on films or culture dish. This indicates a preservation of their original phenotype. At end, dispersion of short fibers with adhered cells is proposed for injection to repair cartilage avoiding chirurgical implantation.

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“…For many applications, the exact chemical structure of chitosan is important and controls the physicochemical properties. It highly depends on the average molar mass (MW), average DA, and distribution of the acetyl groups along the chain (blockwise or random acetyl distribution) [50]. 3 Journal of Nanomaterials diameter, 490 nm; diameter distribution, 390-610 nm).…”

Section: Ideal Characteristic Advantage Referencesmentioning

confidence: 99%

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Fa-dong

Jia

et al. 2020

Journal of Nanomaterials

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Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization, and applications. Information of those polymers together with their processing condition for electrospinning of ultrafine fibers has been summarized in the paper. The application of electrospun natural biopolymer fibers in wound dressings was specifically discussed. Other issues regarding the technology limitations, research challenges, and future trends are also discussed.

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Biomaterials from Chitosan Processed by Electrospinning

Abstract: This article provides an overview on the development of electrospinning applied to synthetic and natural polymers. We discussed specifically the application allowing to produce chitosan mats for tissue engineering and wound healing.

Cited by 5 publications

References 25 publications

Novel Nanofibers Made of Chitosan/Hyaluronan Electrostatic Complex

Novel Nanofibers Made of Chitosan/Hyaluronan Electrostatic Complex

Electrospun Chitosan Nanofibers used for Chondrocyte Development: Influence of the Structure of Fibrillar Support

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

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