Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers

Camponogara, Francesca; Zanotti, Federica; Tiengo, Elena; Zanolla, Ilaria; Pishavar, Elham; Soliani, Elisa; Scatto, Marco; Gargiulo, Paolo; Zambito, Ylenia; Luca, Stefano De; Ferroni, Letizia; Zavan, Barbara

doi:10.3390/ijms23158245

Cited by 2 publications

(1 citation statement)

References 193 publications

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“…Lastly, this work found it appropriate to investigate ADNVs’ applicability in cosmetic formulations and medical dressing. Hyaluronic acid is a natural polysaccharide, which has been used in various forms and with numerous functionalization [ 69 , 70 , 71 , 72 , 73 ]. From topical applications to drug delivery, it has been adopted for biomedical and cosmetic solutions.…”

Section: Discussionmentioning

confidence: 99%

Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action

Zanolla

Zanotti

Tiengo

et al. 2022

Cells

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Skin ageing is strictly related to chronic inflammation of the derma and the decay of structural proteins of the extracellular matrix. Indeed, it has become common practice to refer to this phenomenon as inflammageing. Biotech innovation is always in search of new active principles that induce a youthful appearance. In this paper, apple-derived nanovesicles (ADNVs) were investigated as novel anti-inflammatory compounds, which are able to alter the extracellular matrix production of dermal fibroblasts. Total RNA sequencing analysis revealed that ADNVs negatively influence the activity of Toll-like Receptor 4 (TLR4), and, thus, downregulate the NF-κB pro-inflammatory pathway. ADNVs also reduce extracellular matrix degradation by increasing collagen synthesis (COL3A1, COL1A2, COL8A1 and COL6A1) and downregulating metalloproteinase production (MMP1, MMP8 and MMP9). Topical applications for skin regeneration were evaluated by the association of ADNVs with hyaluronic-acid-based hydrogel and patches.

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Section: Discussionmentioning

confidence: 99%

Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action

Zanolla

Zanotti

Tiengo

et al. 2022

Cells

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Galvanic Deposition of Calcium Phosphate/Bioglass Composite Coating on AISI 316L

et al. 2023

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Calcium phosphate/Bioglass composite coatings on AISI 316L were investigated with regard to their potential role as a beneficial coating for orthopedic implants. These coatings were realized by the galvanic co-deposition of calcium phosphate compounds and Bioglass particles. A different amount of Bioglass 45S5 was used to study its effect on the performance of the composite coatings. The morphology and chemical composition of the coatings were investigated before and after their aging in simulated body fluid. The coatings uniformly covered the AISI 316L substrate and consisted of a brushite and hydroxyapatite mixture. Both phases were detected using X-ray diffraction and Raman spectroscopy. Additionally, both analyses revealed that brushite is the primary phase. The presence of Bioglass was verified through energy-dispersive X-ray spectroscopy, which showed the presence of a silicon peak. During aging in simulated body fluid, the coating was subject to a dynamic equilibrium of dissolution/reprecipitation with total conversion in only the hydroxyapatite phase. Corrosion tests performed in simulated body fluid at different aging times revealed that the coatings made with 1 g/L of Bioglass performed best. These samples have a corrosion potential of −0.068V vs. Ag/AgCl and a corrosion current density of 8.87 × 10−7 A/cm2. These values are better than those measured for bare AISI 316L (−0.187 V vs. Ag/AgCl and 2.52 × 10−6 A/cm2, respectively) and remained superior to pure steel for all 21 days of aging. This behavior indicated the good protection of the coating against corrosion phenomena, which was further confirmed by the very low concentration of Ni ions (0.076 ppm) released in the aging solution after 21 days of immersion. Furthermore, the absence of cytotoxicity, verified through cell viability assays with MC3T3-E1 osteoblastic cells, proves the biocompatibility of the coatings.

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Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers

Cited by 2 publications

References 193 publications

Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action

Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action

Galvanic Deposition of Calcium Phosphate/Bioglass Composite Coating on AISI 316L

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