Biomaterials for Regeneration of Tendons and Ligaments

Hammoudi, Taymour M.; Temenoff, Johnna S.

doi:10.1007/978-3-7091-0385-2_11

Cited by 5 publications

(5 citation statements)

References 197 publications

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“…For this reason, in first approximation, the mechanical behavior of the mixed region can be homogenized using a Voigt model consisting of two springs in parallel. In this case the mechanical response is described by the equation (6):…”

Section: Discussionmentioning

confidence: 99%

“…In fibrous enthesis, Sharpey's collagen fibers connect the ligament and bone forming acute angles [7]. The fibrocartilaginous enthesis consists of a graded transition zone composed of four different tissues: fibrous connective tissue with typical fibroblasts, calcified and uncalcified fibrocartilage, and bone tissue with typical osteocytes [6]. Different hypotheses tried to explain the ligament-tobone interface tissue healing process, which is still not completely understood.…”

Section: Introductionmentioning

confidence: 99%

“…Two different types of ligament-to-bone interfaces can be distinguished: fibrous (indirect) and fibrocartilaginous (direct) entheses [6]. In fibrous enthesis, Sharpey's collagen fibers connect the ligament and bone forming acute angles [7].…”

Section: Introductionmentioning

confidence: 99%

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Triphasic scaffolds for the regeneration of the bone–ligament interface

Criscenti¹,

Longoni²,

Luca³

et al. 2016

Biofabrication

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A triphasic scaffold (TPS) for the regeneration of the bone-ligament interface was fabricated combining a 3D fiber deposited polycaprolactone structure and a polylactic co-glycolic acid electrospun. The scaffold presented a gradient of physical and mechanical properties which elicited different biological responses from human mesenchymal stem cells. Biological test were performed on the whole TPS and on scaffolds comprised of each single part of the TPS, considered as the controls. The TPS showed an increase of the metabolic activity with culturing time that seemed to be an average of the controls at each time point. The importance of differentiation media for bone and ligament regeneration was further investigated. Metabolic activity analysis on the different areas of the TPS showed a similar trend after 7 days in both differentiation media. Total alkaline phosphatase (ALP) activity analysis showed a statistically higher activity of the TPS in mineralization medium compared to the controls. A different glycosaminoglycans amount between the TPS and its controls was detected, displaying a similar trend with respect to ALP activity. Results clearly indicated that the integration of electrospinning and additive manufacturing represents a promising approach for the fabrication of scaffolds for the regeneration of tissue interfaces, such as the bone-to-ligament one, because it allows mimicking the structural environment combining different biomaterials at different scales.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Triphasic scaffolds for the regeneration of the bone–ligament interface

Criscenti¹,

Longoni²,

Luca³

et al. 2016

Biofabrication

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show abstract

“…As extracted from the previous sections, the materials utilized in the preparation of the NGC should possess a compendium of as much convenient properties as possible, in order to cope with all the high PNR requirements. Table ,− summarizes a selection of different materials with potential for application in PNR, their origin, as well as their main advantages and disadvantages are described. A more detailed explanation about the possible processing methods and roles of these materials in PNR will be further provided.…”

Section: Biomaterialsmentioning

confidence: 99%

Peripheral Nerve Injury: Current Challenges, Conventional Treatment Approaches, and New Trends in Biomaterials-Based Regenerative Strategies

López-Cebral

Silva‐Correia

Reis

et al. 2017

ACS Biomater. Sci. Eng.

106

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Damage to peripheral nerves is a widely extended health problem, causing important socioeconomic costs worldwide. Indeed, peripheral nerve injuries (PNI) have been concerning the medical community for many decades. Nevertheless, despite the increase in knowledge in the injury physiopathology and the great research efforts being undertaken, the current standard grafting strategies used to repair PNI are not as efficient as desired. Although alternative engineered nerve grafts are already commercialized, their clinical performance is suboptimal. In this review, a general description of the circumstances and repercussions surrounding the PNI pathological state are presented, together with the treatment limitations and current challenges when addressing both short- and long-gap defects. In addition, potential therapeutic molecules are considered, while innovative regenerative strategies have been identified. Finally, the most relevant advances on the use of a wide range of biomaterials for the development of novel medical devices are also overviewed in depth, considering strategies making use of either empty or filled nerve conduits for guided tissue regeneration.

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“…Direct entheses have a fibrocartilaginous region between the bone and the highly organized collagen fibers of the ligament, tendon, etc. [10] Conversely, indirect entheses are usually observed on the shafts of long bones and have fibers that connect directly into bone (Sharpey’s fibers) (Fig. 2).…”

Section: Introductionmentioning

confidence: 99%

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

et al. 2017

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Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.

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Biomaterials for Regeneration of Tendons and Ligaments

Cited by 5 publications

References 197 publications

Triphasic scaffolds for the regeneration of the bone–ligament interface

Triphasic scaffolds for the regeneration of the bone–ligament interface

Peripheral Nerve Injury: Current Challenges, Conventional Treatment Approaches, and New Trends in Biomaterials-Based Regenerative Strategies

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

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