Biomaterials for Drug Delivery: Sources, Classification, Synthesis, Processing, and Applications

Adeosun, S. O.; Ilomuanya, Margaret O.; Gbenebor, O. P.; Dada, Modupeola; Odili, Cletus C.

doi:10.5772/intechopen.93368

Cited by 19 publications

(19 citation statements)

References 133 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, the nanocarriers can be used to release the cargos by activating them. Secondly, the polymer of the charged surface can be positive to get internalized by the cells that are targeted [ 65 ]. Table 8 lists the various polymers used in the development of controlled release drug delivery systems (CRDDS).…”

Section: Concept Of Biomaterials In Controlled Drug Deliverymentioning

confidence: 99%

Controlled Drug Delivery Systems: Current Status and Future Directions

2021

View full text Add to dashboard Cite

The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional drug delivery systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma drug level and are unable to achieve sustained release. Without an efficient delivery mechanism, the whole therapeutic process can be rendered useless. Moreover, the drug has to be delivered at a specified controlled rate and at the target site as precisely as possible to achieve maximum efficacy and safety. Controlled drug delivery systems are developed to combat the problems associated with conventional drug delivery. There has been a tremendous evolution in controlled drug delivery systems from the past two decades ranging from macro scale and nano scale to intelligent targeted delivery. The initial part of this review provides a basic understanding of drug delivery systems with an emphasis on the pharmacokinetics of the drug. It also discusses the conventional drug delivery systems and their limitations. Further, controlled drug delivery systems are discussed in detail with the design considerations, classifications and drawings. In addition, nano-drug delivery, targeted and smart drug delivery using stimuli-responsive and intelligent biomaterials is discussed with recent key findings. The paper concludes with the challenges faced and future directions in controlled drug delivery.

show abstract

Section: Concept Of Biomaterials In Controlled Drug Deliverymentioning

confidence: 99%

Controlled Drug Delivery Systems: Current Status and Future Directions

2021

View full text Add to dashboard Cite

show abstract

“…Similarly, an investigative study of high molecular weight chitosan in wound healing showed exceptionally good re-epithelialization and fast wound closure compared to fucidin-ointment treated wounds [13]. Collagen and gelatin nanofibrous scaffolds are fabricated for wound healing and cartilaginous tissue regeneration respectively [15,16] and nanofibrous scaffolds of hyaluronic acid mimics the ECM essential in controlling cellular function [2,17].…”

Section: Biomaterials and Wound Healingmentioning

confidence: 99%

“…Margaret O. Ilomuanya 1 *, Ibilola M. Cardoso-Daodu 1 , Uloma N. Ubani-Ukoma 1 and Adannaya C. Adebona 2…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…These materials are broadly divided into three classes -synthetic polymers (usually hydrophobic), natural polymers and inorganic polymers [1]. These polymeric materials have found usefulness in various aspects of medicine such as tissue engineering [1], drug delivery [2], gene therapies [3], wound healing etc. Wounds occur when an intact body organ or tissue is compromised.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polymeric Biomaterials for Wound Healing Incorporating Plant Extracts and Extracellular Matrix Components

Ilomuanya¹,

Cardoso-Daodu²,

Ubani-Ukoma³

et al. 2022

Recent Advances in Wound Healing

Self Cite

View full text Add to dashboard Cite

Biomaterials are constructed to promote or stimulate the processes of wound healing. Polymeric biomaterials can be used to hydrate the wound and serve as barrier to pathogens with plant extracts, antimicrobial agents and extracellular components incorporated to stimulate the healing process. The biological and physical augmentation provided by extracellular matrix derived implants continues facilitate innovation in biomaterials utilized in management of nonhealing wounds. Tissue-processing methodologies can birth extracellular matrix-based devices with characteristic post-implantation responses ranging from the classic foreign body encapsulation of a permanent implant, to one where the implant is degraded and resorbed, to one where the processed extracellular matrix implant is populated by local fibroblasts and supporting vasculature to produce, a viable and metabolically active tissue. Extracellular matrix components and plant extracts have been shown to possesses pharmacological properties with potential for use in the treatment of skin diseases and wound healing. Antioxidant, anti-inflammatory assays, and wound healing assays have been shown to support the dermatological and wound healing usage of these medicinal plants extracts.

show abstract

“…Moreover, in the field of pharmacology, electrospun nanofibers have generated significant interest thanks to biofunctional systems. They allow a direct interaction between polymers and drugs, and for this reason, it is of paramount importance to find a polymer that is compatible with the drug and that both materials are biocompatible [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment

et al. 2021

View full text Add to dashboard Cite

This work biosynthesized poly(γ-glutamic acid) (γ-PGA) produced by Bacillus licheniformis ATCC-9945a. This material was utilized to prepare electrospun nanofibers with solutions of 10% polyvinyl alcohol (PVA) (w/v) mixed with γ-PGA at 5 and 10% w/v, intended as a wound dressing for diabetic foot treatment. These solutions were loaded with chlorogenic acid (CGA), an active hypoglycemic agent. Morphological analysis showed a decrease in size of the fibers with the combination of PVA/γ-PGA compared to pure PVA nanofibers, which was attributed to the hydrogen bonding interactions between the glutaraldehyde vapors, γ-PGA, and PVA that permitted nanofiber cross-linking and allowed CGA release. The in vitro release analysis showed that the PVA membranes reached 28% delivery after the first 24 h. Notably, the nanofiber mat with PVA blended with 5% γ-PGA reached 57% delivery, and the PVA nanofiber with 10% γ-PGA reached 66% release after the same amount of time. The rate constant for the release kinetics showed that PVA with 5% γ-PGA had a higher value than that of the other samples, reaching saturation first.

show abstract

Biomaterials for Drug Delivery: Sources, Classification, Synthesis, Processing, and Applications

Cited by 19 publications

References 133 publications

Controlled Drug Delivery Systems: Current Status and Future Directions

Controlled Drug Delivery Systems: Current Status and Future Directions

Polymeric Biomaterials for Wound Healing Incorporating Plant Extracts and Extracellular Matrix Components

Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment

Contact Info

Product

Resources

About