Biomaterials for cardiac tissue engineering

Radišić, Milica

doi:10.1088/1748-6041/10/3/030301

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Cardiac tissue engineering aims to develop and use reliable mimics of cardiac muscle for restoring physiology 1 . Careful selection of cardiomyocytes and development of biomaterials that support these cells with an appropriate feature for electromechanical stimulation are recommended for successful cardiac tissue engineering 2 . Many biomaterials have gained attention in cardiac repair because of their ability to serve as scaffolds that improve cell survival and function 3 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Careful selection of cardiomyocytes and development of biomaterials that support these cells with an appropriate feature for electromechanical stimulation are recommended for successful cardiac tissue engineering. 2 Many biomaterials have gained attention in cardiac repair because of their ability to serve as scaffolds that improve cell survival and function. 3 Indeed, engineered cardiac tissues with conductive materials like carbon-based nanomaterials, 4 carbon nanotubes, 5 metal derived materials, 6 and conductive polymers such as polyaniline, polythiophene, and polypyrrole 7 have been demonstrated to restore electrophysiological function of damaged heart.…”

Section: Introductionmentioning

confidence: 99%

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A porcine cholecystic extracellular matrix conductive scaffold for cardiac tissue repair

et al. 2022

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Cardiac tissue engineering using cells, scaffolds or signaling molecules is a promising approach for replacement or repair of damaged myocardium. This study addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle-incorporated porcine cholecystic extracellular matrix for the same. The scaffold had an electrical

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A porcine cholecystic extracellular matrix conductive scaffold for cardiac tissue repair

et al. 2022

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“…In order to enhance cell retention and maximize reparative paracrine secretion, scaffolds are often used for the implantation of a therapeutic stem cell source. , Electrospinning has been used in many different regenerative medicine applications over the past several decades because of its capability to generate scaffolds that mimic the in vivo cell microenvironment. , Electrospinning can produce scaffolds made of a highly porous network of fibers in the nanometer range, allowing for the effective transportation of nutrients and wastes while mimicking the collagen nanofibers in the extracellular matrix (ECM). Importantly, the electrospun fibers can be oriented parallel to each other along one specific direction, giving the fiber-based scaffold an anisotropic structure similar to that of the myocardium.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofiber-Based Patches for the Delivery of Cardiac Progenitor Cells

Streeter

Xue

Xia

et al. 2019

ACS Appl. Mater. Interfaces

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Congenital heart disease is the number one cause of birth defect-related death because it often leads to right ventricular heart failure (RVHF). One promising avenue to combat this RVHF is the use of cardiac patches composed of stem cells and scaffolds. Herein, we demonstrate a reparative cardiac patch by combining neonatal or child c-kit+ progenitor cells (CPCs) with a scaffold composed of electrospun polycaprolactone nanofibers. We examined different parameters of the patch, including the alignment, composition, and surface properties of the nanofibers, as well as the age of the CPCs. The patch based on uniaxially aligned nanofibers successfully aligned the CPCs. With the inclusion of gelatin in the nanofiber matrix and/or coating of fibronectin on the surface of the nanofibers, the metabolism of both neonatal and child CPCs was generally enhanced. The conditioned media collected from both patches based on aligned and random nanofibers could reduce the fibrotic gene expression in rat cardiac fibroblasts, following stimulation with transforming growth factor β. Furthermore, the conditioned media collected from the nanofiber-based patches could lead to the formation of tubes of human umbilical vein endothelial cells, indicating the pro-angiogenic capability of the patch. Taken together, the electrospun nanofiber-based patches are a suitable delivery vehicle for CPCs and can confer reparative benefit through anti-fibrotic and pro-angiogenic paracrine signaling.

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