Biomaterials for Adhesion in Orthopedic Applications: A Review

Zaokari, Younis; Persaud, Alicia; Ibrahim, Abeer

doi:10.1016/j.engreg.2020.07.002

Cited by 36 publications

(24 citation statements)

References 61 publications

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“…In general, ATESs are designed to serve two purposes: adhesion (fixation) onto the tissue surfaces and mimicking the ECM niche for cell proliferation, differentiation, growth, to restore tissue structure and function. Based on these primary functions, the following properties are required for a 3D scaffold system to qualify as an ATES ( Table 1 ): (1) sufficient adhesive properties to tolerate wet and dynamic in vivo environment and the various forces that exist; (2) biocompatibility and low cell toxicity that enable cell survival and function, as well as integration with the surrounding (host) native tissue; (3) proper biodegradation and swelling behavior that accommodates the tissue regeneration rate; (4) incorporated porosity and vasculature that provide sufficient oxygen and nutrients; (5) Young’s modulus and stiffness that resemble those of the native tissue; and (6) elasticity or flexibility to withstand tensional or dynamic forces in cases such as nerve or myocardial regeneration ( Lauto et al, 2008 ; Zaokari et al, 2020 ).…”

Section: Main Characteristics and Requirements Of Atessmentioning

confidence: 99%

“…Further, flexibility and elasticity of the scaffold are prominent in applications for lung and gastrointestinal adhesion ( Tsuchiya et al, 2020 ). Also, harsh conditions in diseased states or post-surgery should be taken into account for in vivo applications ( Zaokari et al, 2020 ). Such harsh conditions, such as low pH, oxidative environment, and high immune response, can affect degradation rate, swelling ratio, and cohesive strength of scaffolds, leading to a diminished adhesive strength in the long term ( Taboada et al, 2020 ).…”

Section: Main Characteristics and Requirements Of Atessmentioning

confidence: 99%

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Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Chen

Gil

Ning

et al. 2021

Front. Bioeng. Biotechnol.

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A variety of suture and bioglue techniques are conventionally used to secure engineered scaffold systems onto the target tissues. These techniques, however, confront several obstacles including secondary damages, cytotoxicity, insufficient adhesion strength, improper degradation rate, and possible allergic reactions. Adhesive tissue engineering scaffolds (ATESs) can circumvent these limitations by introducing their intrinsic tissue adhesion ability. This article highlights the significance of ATESs, reviews their key characteristics and requirements, and explores various mechanisms of action to secure the scaffold onto the tissue. We discuss the current applications of advanced ATES products in various fields of tissue engineering, together with some of the key challenges for each specific field. Strategies for qualitative and quantitative assessment of adhesive properties of scaffolds are presented. Furthermore, we highlight the future prospective in the development of advanced ATES systems for regenerative medicine therapies.

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Section: Main Characteristics and Requirements Of Atessmentioning

confidence: 99%

Section: Main Characteristics and Requirements Of Atessmentioning

confidence: 99%

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Chen

Gil

Ning

et al. 2021

Front. Bioeng. Biotechnol.

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“…[ 12 , 13 ] Drawing upon this process, materials have been developed to regulate fibrin formation by modulating the duration of the linear growth and lateral aggregation phases. [ 14 ]…”

Section: Introductionmentioning

confidence: 99%

Mesopore Controls the Responses of Blood Clot‐Immune Complex via Modulating Fibrin Network

Shan

Xie

et al. 2021

Advanced Science

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Formation of blood clots, particularly the fibrin network and fibrin network‐mediated early inflammatory responses, plays a critical role in determining the eventual tissue repair or regeneration following an injury. Owing to the potential role of fibrin network in mediating clot‐immune responses, it is of great importance to determine whether clot‐immune responses can be regulated via modulating the parameters of fibrin network. Since the diameter of D‐terminal of a fibrinogen molecule is 9 nm, four different pore sizes (2, 8, 14, and 20 nm) are rationally selected to design mesoporous silica to control the fibrinogen adsorption and modulate the subsequent fibrin formation process. The fiber becomes thinner and the contact area with macrophages decreases when the pore diameters of mesoporous silica are greater than 9 nm. Importantly, these thinner fibers grown in pores with diameters larger than 9 nm inhibit the M1‐polorazation of macrophages and reduce the productions of pro‐inflammatory cytokines and chemokines by macrophages. These thinner fibers reduce inflammation of macrophages through a potential signaling pathway of cell adhesion‐cytoskeleton assembly‐inflammatory responses. Thus, the successful regulation of the clot‐immune responses via tuning of the mesoporous pore sizes indicates the feasibility of developing advanced clot‐immune regulatory materials.

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“…However, the functionalized molecule has no chemical moieties with adhesive properties. These methods do not have the adhesive property needed for certain medical applications such as implant materials for surgical recovery [ 11 , 19 ]. Adhesive properties enable the research to be conducted in the past few years to develop an adhesive HA-derived hydrogel for medical treatment [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Phenol–Hyaluronic Acid Conjugates: Correlation of Oxidative Crosslinking Pathway and Adhesiveness

Kim

Son

et al. 2021

Polymers

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Hyaluronic acid (HA) is a natural polysaccharide with great biocompatibility for a variety of biomedical applications, such as tissue scaffolds, dermal fillers, and drug-delivery carriers. Despite the medical impact of HA, its poor adhesiveness and short-term in vivo stability limit its therapeutic efficacy. To overcome these shortcomings, a versatile modification strategy for the HA backbone has been developed. This strategy involves tethering phenol moieties on HA to provide both robust adhesiveness and intermolecular cohesion and can be used for oxidative crosslinking of the polymeric chain. However, a lack of knowledge still exists regarding the interchangeable phenolic adhesion and cohesion depending on the type of oxidizing agent used. Here, we reveal the correlation between phenolic adhesion and cohesion upon gelation of two different HA–phenol conjugates, HA–tyramine and HA–catechol, depending on the oxidant. For covalent/non-covalent crosslinking of HA, oxidizing agents, horseradish peroxidase/hydrogen peroxide, chemical oxidants (e.g., base, sodium periodate), and metal ions, were utilized. As a result, HA–catechol showed stronger adhesion properties, whereas HA–tyramine showed higher cohesion properties. In addition, covalent bonds allowed better adhesion compared to that of non-covalent bonds. Our findings are promising for designing adhesive and mechanically robust biomaterials based on phenol chemistry.

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Biomaterials for Adhesion in Orthopedic Applications: A Review

Cited by 36 publications

References 61 publications

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

Mesopore Controls the Responses of Blood Clot‐Immune Complex via Modulating Fibrin Network

Phenol–Hyaluronic Acid Conjugates: Correlation of Oxidative Crosslinking Pathway and Adhesiveness

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