Biomaterials and osteoradionecrosis of the jaw: Review of the literature according to the SWiM methodology

Lagarrigue, Prescillia; Soulié, Jérémy; Chabrillac, Emilien; Darcos, Vincent; Grossin, David; Vergez, S.; Combes, Christèle; Dupret‐Bories, Agnès

doi:10.1016/j.anorl.2021.06.006

Cited by 3 publications

(7 citation statements)

References 85 publications

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“…Concerning PDLLA_1 synthesis, the starting polymer, PDLLA-OH, with a theoretical molecular weight of M n 10 200 g•mol −1 was prepared by ROP of D,L-lactide in solution using a feed ratio of D,L-lactide/benzyl alcohol/Sn(Oct) 2 of 70/1/0.1. The obtained PDLLA-OH was characterized both by 1 H NMR spectroscopy (Figure S2A) and SEC analysis in THF with PS standards (Figure S2B). The PDLLA-OH molecular weight, M n,NMR 8400 g•mol −1 , was determined using the relative intensity of NMR signals of lactic acid units (δ 5.11 ppm, b and δ 4.33 ppm, d) and phenyl group (δ 7.3 ppm, a).…”

Section: Resultsmentioning

confidence: 99%

“…Small bone defects related or consecutive to maxillofacial pathologies/surgeries require medical implants of a few cubic centimeters for bone reconstruction. Such a type of biomaterial should , (i) stimulate the formation of a new bone in critical bone defects, thanks to cell differentiation and proliferation; (ii) be osteoconductive and promote cell adhesion; (iii) exhibit high porosity (pore size, anisotropy, volume) to support cell colonization and angiogenesis; (iv) maintain adequate mechanical properties during manipulation by the surgeon; (v) be resorbed after at least 6 months; and (vi) demonstrate additional properties such as proangiogenic and antibacterial effects for some pathologies like mandibular osteoradionecrosis.…”

Section: Introductionmentioning

confidence: 99%

“…The resulting polymer, named PDLLA_2, was used as free polymer chains during the nanocomposite scaffold elaboration to enhance link formation between PDLLA-grafted bioglass nanoparticles. 1 36 First, to synthesize silica nanoparticles, 1.3 L of ethanol, MiliQ water (6 M), and ammonium hydroxide (0.28 M) were mixed under vigorous stirring. After 30 min, one shot of TEOS (0.28 M), premixed with 200 mL of ethanol, was added to the solution and the latter was left under stirring for 17 h. Resulting silica nanoparticles were collected by centrifugation (10 min at 4200 rpm) and redispersed into 100 mL of MiliQ water using an ultrasonic probe (15 min).…”

Section: Introductionmentioning

confidence: 99%

“…Polymer Characterization. The synthesized and functionalized PDLLAs were characterized by 1 H NMR and size exclusion chromatography (SEC). 1 H NMR spectra were recorded using a Bruker spectrometer (AMX300) operating at 300 MHz in CDCl 3 as a solvent.…”

Section: Introductionmentioning

confidence: 99%

“…The synthesized and functionalized PDLLAs were characterized by 1 H NMR and size exclusion chromatography (SEC). 1 H NMR spectra were recorded using a Bruker spectrometer (AMX300) operating at 300 MHz in CDCl 3 as a solvent. The chemical shifts were referenced to the peak of residual nondeuterated solvents.…”

Section: Introductionmentioning

confidence: 99%

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Poly(d,l-lactide)-Grafted Bioactive Glass Nanoparticles: From Nanobricks to Freeze-Cast Scaffolds for Bone Substitution

Lagarrigue

Darcos

Tenailleau

et al. 2022

ACS Appl. Nano Mater.

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This paper focuses on an integrative “bricks-and-mortar” approach involving bioactive glass nanoparticles (bricks) covalently functionalized with a customized polymer (mortar) combined with the freeze-casting process. With the aim of obtaining a macroporous composite for bone substitution, composed of a spatially homogeneous assembly of nanoscale objects, we establish a method for the systematic elaboration of nanocomposite scaffolds. It was implemented through several steps from the synthesis of functionalized poly(d,l-lactide) (PDLLA) and SiO2–CaO binary bioactive glass nanoparticles (diameter around 164 nm) to the unidirectional freeze-casting process. The different stages include the first description of controlled PDLLA (M n 8400 g·mol–1) grafting onto bioactive glass nanoparticle surfaces, their fine characterization and grafting quantification, and their mixing with free PDLLA chains (83 400 g·mol–1) during suspension formulation. This paper emphasizes the effect of the working temperature during the freeze-casting process on the multiscale spatial organization of resulting scaffolds such as the porosity morphology (lamellar and tubular), size (from 30 to 380 μm), anisotropy, and orientation. In addition to porosity, our results demonstrate a rosary-like organization of PDLLA-grafted nanoparticles in pore walls. The higher homogeneity in the spatial distribution of grafted nanoparticles over the height of scaffolds and at a micron scale confirms the validity of the “bricks-and-mortar” concept to prevent or limit aggregation. In particular, this study highlights the correlation between nanoparticle functionalization and mechanical properties, especially the recovery rate after compression tests. These results lay the foundation for the development of tunable materials for bone substitution, via potential enhancement of bioactivity and cell colonization.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Poly(d,l-lactide)-Grafted Bioactive Glass Nanoparticles: From Nanobricks to Freeze-Cast Scaffolds for Bone Substitution

Lagarrigue

Darcos

Tenailleau

et al. 2022

ACS Appl. Nano Mater.

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Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem

Kamarudin

Bhaskar

et al. 2023

International Materials Reviews

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Peri-implant infection is rapidly becoming anif not the mostimportant clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies.

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The Use of Hydrogel-Based Materials for Radioprotection

Liu

Ding

et al. 2023

Gels

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Major causes of the radiation-induced disease include nuclear accidents, war-related nuclear explosions, and clinical radiotherapy. While certain radioprotective drug or bioactive compounds have been utilized to protect against radiation-induced damage in preclinical and clinical settings, these strategies are hampered by poor efficacy and limited utilization. Hydrogel-based materials are effective carriers capable of enhancing the bioavailability of compounds loaded therein. As they exhibit tunable performance and excellent biocompatibility, hydrogels represent promising tools for the design of novel radioprotective therapeutic strategies. This review provides an overview of common approaches to radioprotective hydrogel preparation, followed by a discussion of the pathogenesis of radiation-induced disease and the current states of research focused on using hydrogels to protect against these diseases. These findings ultimately provide a foundation for discussions of the challenges and future prospects associated with the use of radioprotective hydrogels.

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Biomaterials and osteoradionecrosis of the jaw: Review of the literature according to the SWiM methodology

Cited by 3 publications

References 85 publications

Poly(d,l-lactide)-Grafted Bioactive Glass Nanoparticles: From Nanobricks to Freeze-Cast Scaffolds for Bone Substitution

Poly(d,l-lactide)-Grafted Bioactive Glass Nanoparticles: From Nanobricks to Freeze-Cast Scaffolds for Bone Substitution

Biomaterial strategies to combat implant infections: new perspectives to old challenges

The Use of Hydrogel-Based Materials for Radioprotection

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