Biomaterials and Nanoparticles for Hyperthermia Therapy

Deb, Pran Kishore; Odetallah, Haifa'a Marouf Abdellatif; Al-Jaidi, Bilal; Akkinepalli, Raghuram Rao; Al‐Aboudi, Amal; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814427-5.00011-1

Cited by 8 publications

(16 citation statements)

References 138 publications

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“…In fact, both the absorption mass coefficient for X-rays and the ion and electron energy loss increase in targets with a high atomic number, depositing high energy and doses. Moreover, the use of the Au NPs at low concentration, below 1% in weight, allows to enhance the heat transport in cells during hyperthermia applications and to obtain a high contrast imaging of biological samples thanks to the fluorescence emission of the Au atoms and to the optical SPR effects [31]. Thus, if the hyperthermia process is obtained using lamps or lasers whose emitted radiation is transported to the tissue through light fibers, for example, it will be possible to enhance the temperature by the Au NPs absorbance band with a maximum value at the lamp or laser wavelength, obtaining good and local treatment of heat.…”

Section: Discussionmentioning

confidence: 99%

M13 Phages Uptake of Gold Nanoparticles for Radio- and Thermal-Therapy and Contrast Imaging Improvement

et al. 2021

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The presented work deals with the uptake of gold nanoparticles (Au NPs) by M13 phages in solutions. In particular, the Au NPs uptake modalities and their localization in the filamentous phages are evaluated and measured. Gold spherical nanoparticles (with an average diameter of the order of 10 nm) are obtained by laser ablation in water with a sodium citrated surfactant. The interest of such application comes from the possibility to employ living biological structures to transport heavy metallic nanoparticles inside cells of tumoral tissues. Indeed, phages have the capability to introduce Au NPs in the proximity to the cell nucleus, increasing the efficiency of DNA destruction in the tumoral cells by employing low doses of ionizing radiation during radiotherapy and hyperthermia treatments. Several analyses and microscopy characterizations of the prepared phages samples embedding gold nanoparticles are presented, demonstrating that the presence of Au NPs increases the phages imaging contrast.

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Section: Discussionmentioning

confidence: 99%

M13 Phages Uptake of Gold Nanoparticles for Radio- and Thermal-Therapy and Contrast Imaging Improvement

et al. 2021

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“…The effect of alloy percentage on plasmonic peaks can be investigated using equation (8), Since it is possible to change the percentage of gold and silver during the experimental stages, it is necessary to check. According to figure 4(a), as the percentage of gold increases, the extinction cross-section decreases, and the peak of the surface plasmon moves toward the red transition.…”

Section: Effect Of Gold and Silver Alloy Percentage On Plasmonic Peak...mentioning

confidence: 99%

“…In the hyperthermia technique, the temperature within the tumor commonly ranges from 41 to 45 °C. Sharma et al showed that when the temperature exceeds 46 °C (i.e., thermal erosion), it can effectively result in cell necrosis [7][8][9]. In the laser interstitial thermal therapy (LITT) technique proposed by Skandalaki et al, surgery is performed by implanting a laser catheter in the tissue that can produce the required local heat after injection of nanoparticles and localization.…”

Section: Introductionmentioning

confidence: 99%

Investigation of physical properties of Fe₃O₄/Au-Ag@MoS₂ nanoparticles on heat distribution in cancerous liver tissue

Seyedjamali

Farahzadi

Arabi

2022

Mater. Res. Express

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Liver cancer has significantly grown in recent years, and thus its mortality rate has also increased since its symptoms appear to be in malignant stages and the treatment path at this stage is extremely challenging. New therapies based on producing heat in cancerous tissues have opened up a new way to treat cancer. This study investigated the treatment of liver cancer by the magnetic hyperthermia approach and nanoparticles (NPs) such as iron oxide (Fe3O4) core with gold (Au), silver (Ag) alloy shell, and molybdenum disulfide (MoS2) coating. The optical properties of these NPs within the tumor, including the extinction coefficient and surface plasmon peak (SPR) as a function of size, structure, different compositions, and thickness, were also examined using the effective medium theory, followed by assessing the impact of temperature distribution through the analytical modeling of an alternating current magnetic field. The results demonstrated that NPs with a compound of Fe3O4-Au_0.25, Ag_0.75@MoS2, a 3 nm thick cover of Au-Ag alloy, and two layers of MoS2 have the best coefficient of extinction and SPR in the biological window. The Au-Ag alloy improved the extinction coefficient and simultaneously prevented the accumulation of magnetic NPs. Considering that the Au-Ag alloy alone cannot function within the range of biological windows, MoS2 was used, which increased the extinction efficiency at higher wavelengths. The examination of the temperature distribution in the tumor for the proposed alloy compound indicated that after a short time from irradiation initiation, the tumor temperature reaches 45 °C. Further, the temperature distribution within the tumor tissue reached its maximum value at the center of the tumor and decreased dramatically while getting away from the center. Finally, the use of magnetic hyperthermia enabled localized delivery of therapeutic doses to malignant tumors, thereby representing superior performance and efficiency over the photothermal method.

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“…Research interest in this field, especially in the field of nanoparticles, NPs (particle sizes in the range of 1 to 100 nm) are gaining a high interest in this field. The applications of these NPs have been extended to the treatment of various complex ailments and to other fields, such as biomedical and food industries [1][2][3][4]. Simultaneous research in metallic NPs has also emerged for their evolving applicability in various industrial fields of biotechnology [5], electronic [6] drug delivery [7,8] and targeted drug delivery [9] in the pharmaceutical field [10], gene delivery [11], and food industry [12].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold, Iron and Selenium Nanoparticles Using Phytoconstituents: Preliminary Evaluation of Antioxidant and Biocompatibility Potential

et al. 2022

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This study aimed at fabricating gold (Au), iron (Fe) and selenium (Se) nanoparticles (NPs) using various natural plant extracts from the Fertile Crescent area and evaluating their potential application as antioxidant and biocompatible agents to be used in the pharmaceutical field, especially in drug delivery. The Au-NPs were synthesized using Ephedra alata and Pistacia lentiscus extracts, whereas the Fe-NPs and Se-NPs were synthesized using peel, fruit and seed extracts of Punica granatum. The phytofabricated NPs were characterized by the UV-visible spectroscopy, scanning electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction (XRD) and energy-dispersive X-ray (EDS) spectroscopy. Scanning electron microscope technique showed that the synthesized NPs surface was spherical, and the particle size analysis confirmed a particle size of 50 nm. The crystalline nature of the NPs was confirmed by the XRD analysis. All synthesized NPs were found to be biocompatible in the fibroblast and human erythroleukemic cell lines. Se-NPs showed a dose-dependent antitumor activity as evidenced from the experimental results with breast cancer (MCF-7) cells. A dose-dependent, free-radical scavenging effect of the Au-NPs and Se-NPs was observed in the DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay, with the highest effect recorded for Au-NPs.

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Biomaterials and Nanoparticles for Hyperthermia Therapy

Cited by 8 publications

References 138 publications

M13 Phages Uptake of Gold Nanoparticles for Radio- and Thermal-Therapy and Contrast Imaging Improvement

M13 Phages Uptake of Gold Nanoparticles for Radio- and Thermal-Therapy and Contrast Imaging Improvement

Investigation of physical properties of Fe₃O₄/Au-Ag@MoS₂ nanoparticles on heat distribution in cancerous liver tissue

Green Synthesis of Gold, Iron and Selenium Nanoparticles Using Phytoconstituents: Preliminary Evaluation of Antioxidant and Biocompatibility Potential

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Biomaterials and Nanoparticles for Hyperthermia Therapy

Cited by 8 publications

References 138 publications

M13 Phages Uptake of Gold Nanoparticles for Radio- and Thermal-Therapy and Contrast Imaging Improvement

M13 Phages Uptake of Gold Nanoparticles for Radio- and Thermal-Therapy and Contrast Imaging Improvement

Investigation of physical properties of Fe3O4/Au-Ag@MoS2 nanoparticles on heat distribution in cancerous liver tissue

Green Synthesis of Gold, Iron and Selenium Nanoparticles Using Phytoconstituents: Preliminary Evaluation of Antioxidant and Biocompatibility Potential

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Investigation of physical properties of Fe₃O₄/Au-Ag@MoS₂ nanoparticles on heat distribution in cancerous liver tissue