Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Agarwal, Rachit; Garcı́a, Andrés J.

doi:10.1016/j.addr.2015.03.013

Cited by 617 publications

(464 citation statements)

References 151 publications

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“…Such implants can fail due to implant motion, inflammation, bone resorption, and osteolysis. 51 According to our micro-CT analysis, the bone resorption and osteolysis around UHMWPE grafts were ameliorated by SF/VEGF coating. In contrast to the high tensile strength of collagen I fibers, collagen III is less orderly and thinner.…”

mentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

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Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF) was loaded on the surface of materials, the loading was performed by silk fibroin (SF) coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM) and attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8) assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT) analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF coating. This study showed that the method loading VEGF on UHMWPE by SF coating played an effective role on the biological performance of UHMWPE and displayed a great potential application for anterior cruciate ligament reconstruction.

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mentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

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“…Construction of drug-containing films on the implant surface is one of the efficient methods [6,7]. Among various coating approach, the nanofilm based on layer-by-layer (LBL) technique offers one of the greatest advantages--the ability to control the structure and concentration of the incorporated materials in precise-scale by varying the number of coating layers [8].…”

Section: Introductionmentioning

confidence: 99%

Multifuctional Nanofilm for Stimulating Bone Cell Attachment, Proliferation and Preventing Bacterial Colonization

Chen¹,

Sun²,

Jiang³

et al. 2018

J Nanomed Nanotechnol

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“…The functionalization of surfaces of metallic implants in order to form a necessary surface topography as well as a sufficient level of mechanical qualities, biocompatibility, and bioactivity [1] is a challenge for modern medical tools. The modification of the chemical composition and surface roughness of metallic implants significantly enhances the implants' osteoconductive and osteoinductive characteristics [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Ceramic Materials in a Ti–C–Co–Ca3(PO4)2–Ag–Mg System Obtained by MA SHS for the Deposition of Biomedical Coatings

Potanin

Pogozhev

Новиков

et al. 2017

Metals

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This study aimed to obtain biocompatible ceramic materials in a Ti-C-Co-Ca 3 (PO 4 ) 2 -Ag-Mg system by the combustion mode of mechanically activated (MA) reaction mixtures. The influence of the MA time on the reaction ability capability of the mixtures, on their structural and chemical homogeneity, on the combustion parameters and structural-phase conversions in the combustion wave, as well as on the structure and phase composition of the electrode materials has been researched. It was found that the intense treatment of powder mixtures causes plastic deformation of components, the formation of lamellar composite granules, a reduction in the sizes of coherent scattering regions, and also the formation of minor amounts of products. The influence of the activation duration of the ignition temperature and heat release during the combustion of the reaction mixtures was studied. By the method of quenching the combustion front, it was demonstrated that in a combustion wave, chemical transformations occur within the lamellar structures formed during the process of mechanoactivation. It was shown that in the combustion wave, parallel chemical reactions of Ti with C as well as Ti with Co and Ca 3 (PO 4 ) 2 occur, with a Ti-Co-based melt forming the reaction surface. Ceramic electrodes with different contents of Ag and Mg were synthesized by force self-propagating high-temperature synthesis (SHS)-pressing technology using the MA mixtures. The microstructure of the materials consisted of round-shaped grains of nonstoichiometric titanium carbide TiC x grains, intermetallic matrix (TiCo, TiCo 2 , CoTiP), inclusions of Ca and Mg oxides, and grains of the Ag-based solid solution. An increased content of Ag and Mg in the composition of the electrodes, as well as an increased MA duration, leads to an enlargement of the inclusions of the Ag-containing phase size and deterioration in the uniformity of their distribution.

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Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Cited by 617 publications

References 151 publications

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Multifuctional Nanofilm for Stimulating Bone Cell Attachment, Proliferation and Preventing Bacterial Colonization

Ceramic Materials in a Ti–C–Co–Ca3(PO4)2–Ag–Mg System Obtained by MA SHS for the Deposition of Biomedical Coatings

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