Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions

Anderson, James M.; Patel, Jasmine

doi:10.1007/978-1-4614-1031-7_6

Cited by 8 publications

(11 citation statements)

References 155 publications

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“…Because of rapid kinetics, biomaterials and medical devices exposed to blood immediately acquire a layer of plasma and extracellular matrix proteins prior to interacting with host cells . Although the corrodibility of Mg alloys are desirable for temporary biodegradable implant applications, the surfaces of Mg-based implants are highly reactive in physiological medium, which may have adverse effect on the formation of a transient provisional matrix on and around the implants as well as the outcome of the subsequent cell colonization. , Hence, further surface modifications are necessary with respect to the improvement of surface stability and biological compatibility. Existing data supporting the positive role of nanostructured metals in biological application suggest that nanoscale modification of implant surface has the potential to yield a faster and more stable integration of biomedical implants with greater biological activity .…”

Section: Discussionmentioning

confidence: 99%

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF₂ Surface for Vascular Stent Application

Lin

Shen

Chen

et al. 2015

ACS Appl. Mater. Interfaces

116

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Magnesium (Mg) alloys have revolutionized the application of temporary load-bearing implants as they meet both engineering and medical requirements. However, rapid degradation of Mg alloys under physiological conditions remains the major obstacle hindering the wider use of Mg-based implants. Here we developed a simple method of preparing a nanoscale MgF2 film on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to reduce the corrosion rate as well as improve the biological response. The corrosion rate of JDBM alloy exposed to artificial plasma is reduced by ∼20% from 0.337 ± 0.021 to 0.269 ± 0.043 mm·y(-1) due to the protective effect of the MgF2 film with a uniform and dense physical structure. The in vitro cytocompatibility test of MgF2-coated JDBM using human umbilical vein endothelial cells indicates enhanced viability, growth, and proliferation as compared to the naked substrate, and the MgF2 film with a nanoscale flakelike feature of ∼200-300 nm presents a much more favorable environment for endothelial cell adhesion, proliferation, and alignment. Furthermore, the animal experiment via implantation of MgF2-coated JDBM stent to rabbit abdominal aorta confirms excellent tissue compatibility of the well re-endothelialized stent with no sign of thrombogenesis and restenosis in the stented vessel.

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Section: Discussionmentioning

confidence: 99%

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF₂ Surface for Vascular Stent Application

Lin

Shen

Chen

et al. 2015

ACS Appl. Mater. Interfaces

116

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“…The use of medical devices, including catheters, artificial heart valves, prosthetic joints, and other implants, increased dramatically over the past century (Darouiche, 2004 ; Anderson and Patel, 2013 ; Kwakman and Zaat, 2013 ), and has become a major part of modern medicine and our daily life. With the aging society, the demand for medical devices to restore body functions and quality of life increases, and so do the numbers of cases of biomaterial-associated infection (BAI).…”

Section: Biomaterial-associated Infectionsmentioning

confidence: 99%

“…Bacterial biofilm formation is considered to play a major role in the pathogenesis of BAI (Costerton et al, 1999 ; Holmberg et al, 2009 ; Anderson and Patel, 2013 ). Biofilm formation is initiated by bacterial cells attaching to the surfaces of medical devices.…”

Section: Biomaterial-associated Infectionsmentioning

confidence: 99%

Antimicrobial Peptides in Biomedical Device Manufacturing

et al. 2017

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Over the past decades the use of medical devices, such as catheters, artificial heart valves, prosthetic joints, and other implants, has grown significantly. Despite continuous improvements in device design, surgical procedures, and wound care, biomaterial-associated infections (BAI) are still a major problem in modern medicine. Conventional antibiotic treatment often fails due to the low levels of antibiotic at the site of infection. The presence of biofilms on the biomaterial and/or the multidrug-resistant phenotype of the bacteria further impair the efficacy of antibiotic treatment. Removal of the biomaterial is then the last option to control the infection. Clearly, there is a pressing need for alternative strategies to prevent and treat BAI. Synthetic antimicrobial peptides (AMPs) are considered promising candidates as they are active against a broad spectrum of (antibiotic-resistant) planktonic bacteria and biofilms. Moreover, bacteria are less likely to develop resistance to these rapidly-acting peptides. In this review we highlight the four main strategies, three of which applying AMPs, in biomedical device manufacturing to prevent BAI. The first involves modification of the physicochemical characteristics of the surface of implants. Immobilization of AMPs on surfaces of medical devices with a variety of chemical techniques is essential in the second strategy. The main disadvantage of these two strategies relates to the limited antibacterial effect in the tissue surrounding the implant. This limitation is addressed by the third strategy that releases AMPs from a coating in a controlled fashion. Lastly, AMPs can be integrated in the design and manufacturing of additively manufactured/3D-printed implants, owing to the physicochemical characteristics of the implant material and the versatile manufacturing technologies compatible with antimicrobials incorporation. These novel technologies utilizing AMPs will contribute to development of novel and safe antimicrobial medical devices, reducing complications and associated costs of device infection.

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“…Neutrophils (polymorphonuclear leukocytes, PMNs) characterize the acute inflammatory response. Biomaterialmediated inflammatory responses may be modulated by histamine-mediated phagocyte recruitment and phagocyte adhesion to implant surfaces facilitated by adsorbed host fibrinogen, among many other possible host proteins (Anderson and Patel, 2013). Neutrophils are short-lived cells that attack pathogens and foreign materials at the wound site and disintegrate after 24-48 h of wound formation.…”

Section: Host Inflammatory Responsementioning

confidence: 99%

Aging and the Host Response to Implanted Biomaterials

Rao

Avula

Grainger

2015

Host Response to Biomaterials

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Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions

Cited by 8 publications

References 155 publications

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF₂ Surface for Vascular Stent Application

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF₂ Surface for Vascular Stent Application

Antimicrobial Peptides in Biomedical Device Manufacturing

Aging and the Host Response to Implanted Biomaterials

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Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions

Cited by 8 publications

References 155 publications

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application

Antimicrobial Peptides in Biomedical Device Manufacturing

Aging and the Host Response to Implanted Biomaterials

Contact Info

Product

Resources

About

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF₂ Surface for Vascular Stent Application

Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF₂ Surface for Vascular Stent Application