Biomaterial approaches for cardiovascular tissue engineering

Theus, Andrea S.; Tomov, Martin L.; Cetnar, Alex D.; Lima, Bryanna; Nish, Joy E; Mccoy, Kevin; Mahmoudi, Morteza; Serpooshan, Vahid

doi:10.1007/s42247-019-00039-3

Cited by 35 publications

(22 citation statements)

References 143 publications

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“…Initially, cardiomyocytes seeded within biomaterials are round and lack cell–cell interaction. Biomaterials, such as decellularized ECM from primary sources, natural polymers, such as fibrin and collagen, and synthetic polymers, such as polyethylene glycol 57 , can guide cardiac cell spreading and elongation, and enable the establishment of cell–cell interactions to form an electrically coupled tissue that generates strong contraction forces. These biomaterials can be fabricated into hydrogels, macroporous and electrospun scaffolds.…”

Section: Modelling Sex-based Differencesmentioning

confidence: 99%

A framework for developing sex-specific engineered heart models

et al. 2021

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The convergence of tissue engineering and patient-specific stem cell biology has enabled the engineering of in vitro tissue models that allow the study of patient-tailored treatment modalities. However, sex-related disparities in health and disease, from systemic hormonal influences to cellular-level differences, are often overlooked in stem cell biology, tissue engineering and preclinical screening. The cardiovascular system, in particular, shows considerable sex-related differences, which need to be considered in cardiac tissue engineering. In this Review, we analyse sex-related properties of the heart muscle in the context of health and disease, and discuss a framework for including sex-based differences in human cardiac tissue engineering. We highlight how sex-based features can be implemented at the cellular and tissue levels, and how sex-specific cardiac models could advance the study of cardiovascular diseases. Finally, we define design criteria for sex-specific cardiac tissue engineering and provide an outlook to future research possibilities beyond the cardiovascular system.

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Section: Modelling Sex-based Differencesmentioning

confidence: 99%

A framework for developing sex-specific engineered heart models

et al. 2021

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“…Especially, the integration of ECM components into the composition of biomaterials holds great promise for use in muscle regeneration [ 8 ]. Collagen, gelatin, fibrin, matrigel, keratin, hyaluronic acid, silk, and alginate-based hydrogels are some of the most investigated materials for skeletal muscle tissue engineering [ 126 , 127 , 138 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

“…Collagen, the major structural component of ECM, has been used extensively in muscle tissue engineering, where its biocompatibility and resorption make it an attractive choice [ 138 , 139 , 140 , 141 ]. Li and coworkers developed a myoblast-seeded vascularized collagen hydrogel scaffold and implanted it into a VML model consisting of a full-thickness, single muscle defect in the rat biceps femoris muscle to show the importance of vascularization in muscle recovery [ 142 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

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et al. 2021

IJMS

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Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

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“…The hydrogel structure is designed as a three-dimensional cross-linked polymeric network that can absorb a large amount of water and undergo significant structural and volume changes from triggers by external stimuli [1]. These intelligent or smart hydrogel structures are highly attractive for biomedical applications, drug delivery, tissue engineering [2,3], robotics [4,5], and implanting artificial organs. External stimuli can modulate and tune their physical properties, like swelling or shrinking.…”

Section: Introductionmentioning

confidence: 99%

Influence of direct electric field on PMCG-alginate-based microcapsule

et al. 2021

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In this study, the influence of direct electric current on a microcapsule was investigated. The microcapsule consisted of a core from a calcium ion and sodium alginate (SA) complex and the microcapsule membrane was formed by the polyionic complexation of poly(methylene-co-guanidine) (PMCG) and cellulose sulfate (CS). Microcapsules showed swelling and decreasing mechanical properties under the applied electric current, and the microcapsule membrane showed anisotropic swelling on the electrode side. The effect is attributed to an electrokinetic phenomenon, predominant formation of hydroxyl ions, and the diffusion of hydrated ions. The swelling degree of the microcapsule and microcapsule membrane at different pH and the applied electric current under alkali and acidic conditions was investigated. The swelling degree was influenced by the dissociation of the membrane, which was observed after applying the electric field, which was caused by the electrokinetic effect and the neutralization of the polycation (under alkali conditions) or polyanionic (under acidic conditions) segment during membrane formation.

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Biomaterial approaches for cardiovascular tissue engineering

Cited by 35 publications

References 143 publications

A framework for developing sex-specific engineered heart models

A framework for developing sex-specific engineered heart models

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Influence of direct electric field on PMCG-alginate-based microcapsule

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