Biomass‐Derived Mesoporous Carbon Nanomaterials for Drug Delivery and Imaging Applications

Maddiboyina, Balaji; Nakkala, Ramya Krishna

doi:10.1002/9783527832903.ch6

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Two hours were spent at room temperature to evaporate the organic solvents. After evaporation of the solvent, the nanoformulation was diluted with water in a ratio of 1:10 and analysed for particle size (PS) using Malvern zeta sizer (Nano ZS, Malvern Instruments Ltd., 2012) (Maddiboyina, Shanmugapriya, Rasala, & Sivaraman, 2021). The NPs were later centrifuged by 12,000 rpm for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application

Maddiboyina¹,

Roy

Nakkala³

et al. 2023

Chem Biol Drug Des

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Multidrug resistance in breast cancer and the associated side‐effects of anticancer therapies are significant hurdles in chemotherapy‐based treatment. Biodegradable polymeric nano‐based targeted drug delivery technologies showed tremendous advantages in targeted local delivery with limited off‐targeted side effects. Therefore, there is a persistent need to develop targeted nanomedicine systems for treatment of breast cancer. The current research attempted to develop poly (lactic‐co‐glycolic acid) nanoparticles loaded with raloxifene by modified emulsification solvent diffusion evaporation method to improve oral bioavailability by using Taguchi design. It was observed that the optimized formulation (1:4 drug to polymer ratio) poly (lactic‐co‐glycolic acid) showed a mean particle size and Polydispersity index of 218 ± 23.7 nm and 0.231 ± 0.04, respectively. The entrapment efficiency was found to be 82.30% ± 1.02%. In vitro drug delivery was found to be 92.5% ± 1.48% in 40 h. The nanoparticles were to remain stable at 2°C–8°C even after 30 days. Differential scanning calorimetry and Fourier transform infrared spectroscopy characterization techniques showed that there was no interaction between the drug and excipient. Stability studies indicate that polymeric nanoparticles were stable at 2°C–8°C after 6 months. Raloxifene nanoparticles may be the most potent targeting moieties to treat highly invasive and metastatic MCF‐7 breast cancer cells.

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Section: Methodsmentioning

confidence: 99%

Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application

Maddiboyina¹,

Roy

Nakkala³

et al. 2023

Chem Biol Drug Des

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“…These difficulties were evaded or reduced through the advance of a novel genesis of lipid NPs, nanostructured lipid carriers (NLCs), wherein a solid lipid is merged through liquid lipid. Further improvement of NLCs includes the probable modulation of drug release rate (Maddiboyina, Shanmugapriya, Rasala, & Sivaraman, 2021).…”

Section: Lipid‐based Drug Delivery Systemsmentioning

confidence: 99%

“…Over the past 20 years, nanotech has substantially prepared its imprint in all practical fields, including pharmaceutics (Maddiboyina et al, 2022). Manufacturing assessments advocate such approximately 40 percent of lipophilic (LPC) drug or hydrophobic (HBC) drug candidates wane owing to solubility and formulation stability concerns, instigating meaningful exploration activity in progressive LPC delivery technologies (Puri et al, 2010; Rostami et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Perspectives on cutting‐edge nanoparticulate drug delivery technologies based on lipids and their applications

Maddiboyina¹,

Ramaiah²,

Nakkala³

et al. 2023

Chem Biol Drug Des

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Numerous nanotech arenas in therapeutic biology have recently provided a scientific platform to manufacture a considerable swath of unique chemical entities focusing on drugs. Recently, nanoparticulate drug delivery systems have emerged to deliver a specific drug to a specified site. Among all other carriers, lipids possess features exclusive to nanostructured dosage forms. The bioavailability of orally administered drugs is typically negatively affected by their poor water solubility, resulting from the unique chemical moieties introduced. Because of their unique advantages, lipid nanoparticles must become increasingly predictable as a robust delivery mechanism. The enhanced biopharmaceutical properties and significance of lipid‐based targeting technologies such as liposomes, niosomes, solid lipid nanoparticles and micelles are highlighted in this review. Pharmaceutical implications of lipid nanocarriers for the transport and distribution of various therapeutic agents, such as biotechnological products and small pharmaceutical molecules, is a booming topic. Lipid nanoparticles as drug delivery systems have many appealing properties, including high biocompatibility, ease of preparation, tissue specificity, avoidance of reticuloendothelial systems, delayed drug release, scale‐up feasibility, nontoxicity and targeted delivery. The use of lipid nanoparticles to enhance the transport of biopharmaceuticals is currently considered state‐of‐the‐art. Similarly, we critically examine the upcoming guidelines that therapeutic scientists should handle.

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Methicillin-resistant Staphylococcus aureus: novel treatment approach breakthroughs

Maddiboyina,

Roy,

Ramaiah

et al. 2023

Bull Natl Res Cent

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Background Methicillin-resistant Staphylococcus aureus (MRSA) is a common bacterial infection that is a significant source of illness and mortality globally. The advancements in antibiotic therapies continue to be the critical aspects of treating bacterial infections, and their usage has lowered patient mortality and raised life expectancy. Main body of the abstract The ideal treatments for MRSA remain challenging, and the quest for new antibiotic targets and advanced drug delivery systems with safety profiles is necessary to ensure treating MRSA infections adequately in the future. Short conclusion This article primarily focuses on different therapeutic medications and their modes of action for general microbial infections and goes through the latest developments in novel drug delivery technologies, such as hydrogels, lipid particles, nanocarriers, and polymers for MRSA treatment. Graphical Abstract

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Biomass‐Derived Mesoporous Carbon Nanomaterials for Drug Delivery and Imaging Applications

Cited by 3 publications

References 36 publications

Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application

Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application

Perspectives on cutting‐edge nanoparticulate drug delivery technologies based on lipids and their applications

Methicillin-resistant Staphylococcus aureus: novel treatment approach breakthroughs

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