Biomass, Abundant Resources for Synthesis of Mesoporous Silica Material

Akinjokun, Adebola Iyabode; Ojumu, Tunde Victor; Ogunfowokan, AderemiOkunola

doi:10.5772/63463

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…Other additives like cosolvents, compounds to prevent aggregation may also be incorporated based on the requirements. In order to ensure the scale-up of MSNs at reasonable cost, natural perlite materials like pumice rock, rice husk, and renewable biomass could also be explored for the synthesis of MSNs [ 92 , 93 ]. The common chemical constituents explored so far are listed in Table 3 .…”

Section: Synthesis Of Msnsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

et al. 2018

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Recent advancements in drug delivery technologies utilizing a variety of carriers have resulted in a path-breaking revolution in the approach towards diagnosis and therapy alike in the current times. Need for materials with high thermal, chemical and mechanical properties have led to the development of mesoporous silica nanoparticles (MSNs). These ordered porous materials have garnered immense attention as drug carriers owing to their distinctive features over the others. They can be synthesized using a relatively simple process, thus making it cost effective. Moreover, by controlling the parameters during the synthesis; the morphology, pore size and volume and particle size can be transformed accordingly. Over the last few years, a rapid increase in research on MSNs as drug carriers for the treatment of various diseases has been observed indicating its potential benefits in drug delivery. Their widespread application for the loading of small molecules as well as macromolecules such as proteins, siRNA and so forth, has made it a versatile carrier. In the recent times, researchers have sorted to several modifications in the framework of MSNs to explore its potential in drug resistant chemotherapy, antimicrobial therapy. In this review, we have discussed the synthesis of these multitalented nanoparticles and the factors influencing the size and morphology of this wonder carrier. The second part of this review emphasizes on the applications and the advances made in the MSNs to broaden the spectrum of its use especially in the field of biomedicine. We have also touched upon the lacunae in the thorough understanding of its interaction with a biological system which poses a major hurdle in the passage of this carrier to the clinical level. In the final part of this review, we have discussed some of the major patents filed in the field of MSNs for therapeutic purpose.

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Section: Synthesis Of Msnsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

et al. 2018

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“…Although great results have been achieved in producing porous silica NPs, the mentioned chemical methods imply the use of hazardous chemicals harmful to the environment, such as CTAB, or costly techniques (by the use of TEOS, specifically). For this reason, the interest in developing green processes for producing silica NPs from biomass and agricultural waste is becoming of great interest [34], as evidenced by the publication of more than 400 research articles on the topic since 2019 (Figure 3). Nonetheless, the number of reviews published is still few, considering the fast evolution of green silica production is going through.…”

Section: Overview Of General Methods For Sio 2 Nps Classical Chemical...mentioning

confidence: 99%

Sustainable Harnessing of SiO2 Nanoparticles from Rice Husks: A Review of the Best Synthesis and Applications

Rodriguez-Otero,

Vargas,

Galarneau

et al. 2023

Processes

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The extraction of silica particles from rice husks has been extensively studied. This review aims to present the most efficient approach to harnessing rice husk biomass and converting silica into high-value-added materials for direct applications to address current challenges like water purification. Rice husks, as a residue from agriculture, had been largely used as a source of power through direct incineration in major rice-producing countries. However, rice husks present an intriguing opportunity as a renewable source of SiO2, offering a low-cost adsorbent with a high surface area and ease of functionalization that can be transformed into diverse mesoporous silica structures or composites, enabling applications in catalysis, drug delivery, water treatment, etc. This dual potential of rice husks can be harnessed by combining bio-oil and syngas production through pyrolysis with the efficient extraction of SiO2, ensuring the comprehensive utilization of the biomass. This review not only highlights the immense potential of silica nanoparticles but also serves as a roadmap for future investigations, with the ultimate aim of harnessing the full capabilities of this renewable and sustainable resource, contributing to the circular economy by yielding valuable by-products.

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“…Moreover, TEOS, as a provider of the silica species, was reported to influence the meso-architectural ordering of mesoporous silica nanoparticles. It is claimed that the lower amount may be insufficient to craft the mesoporous structure; however, a higher TEOS amount showed a disordered mesostructure ( Akinjokun et al, 2016 ). Therefore, an ideal balance has to be reached between the different components used.…”

Section: Control Of Pore Size Pore Volume and Meso-structural Pore Ordermentioning

confidence: 99%

Biocompatible Supramolecular Mesoporous Silica Nanoparticles as the Next-Generation Drug Delivery System

Mohamed

Oo²,

Chatterjee³

et al. 2022

Front. Pharmacol.

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Supramolecular mesoporous silica nanoparticles (MSNs) offer distinct properties as opposed to micron-sized silica particles in terms of their crystal structure, morphology–porosity, toxicity, biological effects, and others. MSN biocompatibility has touched the pharmaceutical realm to exploit its robust synthesis pathway for delivery of various therapeutic molecules including macromolecules and small-molecule drugs. This article provides a brief review of MSN history followed by special emphasis on the influencing factors affecting morphology–porosity characteristics. Its applications as the next-generation drug delivery system (NGDDS) particularly in a controlled release dosage form via an oral drug delivery system are also presented and shall be highlighted as oral delivery is the most convenient route of drug administration with the economical cost of development through to scale-up for clinical trials and market launch.

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Biomass, Abundant Resources for Synthesis of Mesoporous Silica Material

Cited by 4 publications

References 44 publications

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

Sustainable Harnessing of SiO2 Nanoparticles from Rice Husks: A Review of the Best Synthesis and Applications

Biocompatible Supramolecular Mesoporous Silica Nanoparticles as the Next-Generation Drug Delivery System

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