Biomask for Skin Regeneration

Cheng, Xinjian; Yoo, James J.; Hale, Robert G.

doi:10.2217/rme.14.22

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…With currently available skin grafts, it is difficult to fully cover the whole facial area due to the complex topography [5]. Here, we investigated the facial skin tissue regeneration using the BioMask fabricated by 3D bioprinting strategies.…”

Section: Resultsmentioning

confidence: 99%

“…For example, flap reconstruction was used to match cosmetic features such as color, skin thickness, and texture but is rarely utilized in facial burns due to how common simultaneous injuries are to the neck and chest [4]. Small area skin wounds can be treated using commercial skin substitutes with cellular components and artificial skin grafts; however, facial skin tissue regeneration encounters a unique challenge in wound care [5]. The varied contour and continued movement of the face limit the effectiveness of skin substitutes.…”

Section: Introductionmentioning

confidence: 99%

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3D bioprinted biomask for facial skin reconstruction

et al. 2018

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Skin injury to the face remains one of the greatest challenges in wound care due to the varied contours and complex movement of the face. Current treatment strategies for extensive facial burns are limited to the use of autografts, allografts, and skin substitutes, and these often result in scarring, infection, and graft failure. Development of an effective treatment modality will greatly improve the quality of life and social integration of the affected individuals. In this proof of concept study, we developed a novel strategy, called “BioMask”, which is a customized bioengineered skin substitute combined with a wound dressing layer that snugly fits onto the facial wounds. To achieve this goal, three-dimensional (3D) bioprinting principle was used to fabricate the BioMask that could be customized by patients’ clinical images such as computed tomography (CT) data. Based on a face CT image, a wound dressing material and cell-laden hydrogels were precisely dispensed and placed in a layer-by-layer fashion by the control of air pressure and 3-axis stage. The resulted miniature BioMask consisted of three layers; a porous polyurethane (PU) layer, a keratinocyte-laden hydrogel layer, and a fibroblast-laden hydrogel layer. To validate this novel concept, the bioprinted BioMask was applied to a skin wound on a pre-fabricated face-shaped structure in mice. Through this in vivo study using the 3D BioMask, skin contraction and histological examination showed the regeneration of skin tissue, consisting of epidermis and dermis layers, on the complex facial wounds. Consequently, effective and rapid restoration of aesthetic and functional facial skin would be a significant improvement to the current issues a facial wound patient experience.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D bioprinted biomask for facial skin reconstruction

et al. 2018

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“…Upon implantation for 14 days, non-vascularized bioprinted grafts showed a high degree of inflammation and hemorrhage, as compared to grafts containing human vascular cells. Regeneration of facial skin wounds is highly complicated owing to the varied contours and continuous movement . In this regard, a 3D bioprinting tool has been explored to design customized skin substitutes referred to as “BioMask” that could fit onto the facial wounds.…”

Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 99%

“…Regeneration of facial skin wounds is highly complicated owing to the varied contours and continuous movement. 370 In this regard, a 3D bioprinting tool has been explored to design customized skin substitutes referred to as "BioMask" that could fit onto the facial wounds. Figure 6B shows the workflow for biomask fabrication.…”

Section: Cenpsmentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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“…Tissue engineering could become an appropriate treatment option, but current knowledge does not make it yet applicable for face transplants . For burn patients with less severe impairment, other therapies are being offered such as commercial facial mask dressings and the individualized BioMask for skin regeneration, proposed by Col. Hale from the US Army Institute of Surgical Research . Children and teenagers with visible vascular and pigmentary conditions can opt for cosmetic camouflage, which was proven to be significantly beneficial for vascular malformations and facial lesions, improving the scores in “personal relationships” for facial lesions and the quality of life index of the study participants …”

Section: Alternatives To Pediatric Face Transplantsmentioning

confidence: 99%

Ethical issues in pediatric face transplantation

Benghiac

Garrett

Carter

2017

Pediatric Transplantation

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Facial transplantation has become a reality in adult medicine. Children are subject to congenital craniofacial differences, disease-related, traumatic, or thermochemical craniofacial changes and might be suitable for face transplantation. This manuscript addresses unique ethical issues in considering potential pediatric face transplant. These challenges are operant at the individual, technologic, and psychosocial level for clinicians, investigators, and society.

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Biomask for Skin Regeneration

Cited by 5 publications

References 14 publications

3D bioprinted biomask for facial skin reconstruction

3D bioprinted biomask for facial skin reconstruction

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Ethical issues in pediatric face transplantation

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