Biomarkers to Predict Wound Healing: The Future of Complex War Wound Management

Hahm, George; Glaser, Jacob; Elster, Eric A.

doi:10.1097/prs.0b013e3181fbe291

Cited by 50 publications

(35 citation statements)

References 20 publications

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“…A variety of techniques have been proposed for obtaining sample materials and a multitude of possible wound fluid markers have been investigated. Finding meaningful biomarkers or biomarker panels allowing for the instant detection of infection or the determination of wound healing tendencies are urgently needed (Hahm, Glaser, and Elster 2011). We are convinced that it does make sense to analyse potential biomarkers in wound fluid, which is both easily accessible and can be harvested in a non-invasive way.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory processes such as wound healing involve a complex network of immunoregulatory molecules such as chemokines, cytokines, proteases and their respective counter-regulatory mediators (Hahm, Glaser, and Elster 2011). The analysis of a complete set of mediators can therefore be considered to be of more value than the single analysis of only one single analyte (Gardy et al 2009;de Jager et al 2003).…”

Section: Protein Arrays For the Analysis Of Minute Sample Amountsmentioning

confidence: 99%

“…A biomarker can be defined as a substance that is used as an indicator of normal biological processes, pathologic conditions and therapeutic interventions (Hahm, Glaser, and Elster 2011). They are widely attributed as playing a key role in the diagnosis, prognosis and clinical management of a broad range of disease states (Mueller, Muller, and Perruchoud 2008).…”

Section: Biomarkersmentioning

confidence: 99%

See 2 more Smart Citations

Wound Fluid Diagnostics in Diabetic Foot Ulcers

Löffler¹,

Schmohl²,

Schneiderhan‐Marra³

et al. 2011

Global Perspective on Diabetic Foot Ulcerations

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Section: Discussionmentioning

confidence: 99%

Section: Protein Arrays For the Analysis Of Minute Sample Amountsmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Wound Fluid Diagnostics in Diabetic Foot Ulcers

Löffler¹,

Schmohl²,

Schneiderhan‐Marra³

et al. 2011

Global Perspective on Diabetic Foot Ulcerations

View full text Add to dashboard Cite

“…A need for guided therapy has been well documented in the treatment of chronic wounds resulting from military trauma (19,64). A treating clinician's decision to surgically close a wound is commonly based on subjective and somewhat arbitrary measures, such as the patient's general condition, the appearance of bones and soft tissues, and visual signs of infection or necrosis (65), which are poor indicators of the local inflammatory condition (66).…”

Section: Discussionmentioning

confidence: 99%

Computational Approach To Characterize Causative Factors and Molecular Indicators of Chronic Wound Inflammation

Nagaraja

Wallqvist

Reifman

et al. 2014

The Journal of Immunology

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Chronic inflammation is rapidly becoming recognized as a key contributor to numerous pathologies. Despite detailed investigations, understanding of the molecular mechanisms regulating inflammation is incomplete. Knowledge of such critical regulatory processes and informative indicators of chronic inflammation is necessary for efficacious therapeutic interventions and diagnostic support to clinicians. We used a computational modeling approach to elucidate the critical factors responsible for chronic inflammation and to identify robust molecular indicators of chronic inflammatory conditions. Our kinetic model successfully captured experimentally observed cell and cytokine dynamics for both acute and chronic inflammatory responses. Using sensitivity analysis, we identified macrophage influx and efflux rate modulation as the strongest inducing factor of chronic inflammation for a wide range of scenarios. Moreover, our model predicted that, among all major inflammatory mediators, IL-6, TGF-β, and PDGF may generally be considered the most sensitive and robust indicators of chronic inflammation, which is supported by existing, but limited, experimental evidence.

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“…The field of wound repair promises exciting advances in the identification of biomarkers, including some early findings on the correlation of biomarkers with wound healing in complex traumatic combat wounds. 26 The ability to detect individual biochemical differences in the wound will eventually lead to the development of personalized wound management protocols. With personalized medicine, patients can be cartographers of the roadmap, which offers the risks they are willing to take compared to the quality of life they desire.…”

mentioning

confidence: 99%

What Do Patients Want? Patient Preference in Wound Care

Corbett

Ennis

2014

Advances in Wound Care

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Patient preferences are statements made or actions taken by consumers that reflect their desirability of a range of health options. The concept occupies an increasingly prominent place at the center of healthcare reform, and is connected to all aspects of healthcare, including discovery, research, delivery, outcome, and payment. Patient preference research has focused on shared decisions, decisional aids, and clinical practice guideline development, with limited study in acute and chronic wound care populations. The wound care community has focused primarily on patient focused symptoms and quality of life measurement. With increasing recognition of wound care as a medical specialty and as a public health concern that consumes extensive resources, attention to the preferences of end-users with wounds is necessary. This article will provide an overview of related patient-centered concepts and begin to establish a framework for consideration of patient preference in wound care.From the seminal models of evidence-based practice, patient preference has occupied a prominent place in clinical decision making. More recently, consideration for patient preference emerges as a key component in the redesign of healthcare processes with significance for improving outcome and safety.2 But what are patient preferences? How are they elicited, regarded, and incorporated into recommended action? What interrelated patient-centered concepts have been studied in various patient populations? Lastly, what contribution has the wound care community made to the understanding of patient preference? This article aims to introduce the reader to the issues, begin a dialogue on patient preference in wound care, and suggest opportunities for future discovery.Patient preferences are ''statements by individuals regarding the relative desirability of a range of health experiences, treatment options and health states.'' 3(p259) Preferences reflect beliefs and attitudes of the patient and family, and are related to the process, probability, and severity of potential choices. 4 Patient preference is conceptualized and measured differently across disciplines, from health economics, patient education, psychology, ethics, and using qualitative and quantitative approaches. In the field of medicine, oncology has been the frontrunner in operationalizing methods to determine patient preference for various cancer treatment options, most notably in breast and prostate cancer treatments.

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Biomarkers to Predict Wound Healing: The Future of Complex War Wound Management

Cited by 50 publications

References 20 publications

Wound Fluid Diagnostics in Diabetic Foot Ulcers

Wound Fluid Diagnostics in Diabetic Foot Ulcers

Computational Approach To Characterize Causative Factors and Molecular Indicators of Chronic Wound Inflammation

What Do Patients Want? Patient Preference in Wound Care

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