Biomarkers of treatment-resistant schizophrenia: A systematic review

Pisanu, Claudia; Severino, Giovanni; Minelli, Alessandra; Dierssen, Mara; Potier, Marie-Claude; Fabbri, Chiara; Serretti, Alessandro; Gennarelli, Massimo; Baune, Bernhard T.; Squassina, Alessio

doi:10.1016/j.nsa.2024.104059

Cited by 1 publication

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“…Schizophrenia (Sch) is a severe psychiatric disorder that affects cognitive, behavioral and emotional functioning and is associated with a substantial socioeconomic burden. [1]. Sch affects approximately 24 million people or 1 in 300 people (0.32%) worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the proven efficacy of antipsychotic drugs, 30%-50% of patients with Sch obtain a scarce benefit from conventional treatments. TRS implicates an important burden at 3 levels, as follows: (1) clinical: negative attitude to medication, drug abuse, and nutritional/physical health problems; (2) economic: hospitalizations and polytherapy; and (3) humanistic: depression and social isolation. As a result, dealing with TRS involves a high emotional burden for patients and their caregivers, affecting their quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Hyperexpression of Proinflammatory Cytokines in Blood as a Biomarker of Systemic Inflammatory Response in Schizophrenia: Scoping Review

Shnayder,

Rusanova,

Nasyrova

2024

jour

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Introduction: An imbalance of the genetically determined cytokine response plays a key role in the etiology of treatment-resistant schizophrenia (TRS). In recent years, an attempt has been made to evaluate the prognostic role of systemic inflammation in the development of TRS. The problem requires a multidisciplinary approach on the part of the specialists in the following clinical disciplines: psychiatry, immunology, experimental medicine and pharmacogenetics. The solution of this problem is possible with the involvement of preventive and personalized medicine. The purpose: Evaluation the prognostic role of genetic polymorphisms of pro-inflammatory cytokines in the development of TRS. Materials and Methods: We conducted a keyword-based analysis of the English and Russian-language articles published within the past 5 years. The following databases were used in the study: PubMed, MedLine, Web of Science Core Collection (Clarivate Analytics), Web Science, Russian Science Citation Index, Scopus, Scientific Research, Google Scholar, Oxford Press, and eLibrary. Results: In a number of the analyzed works, an increased level of pro-inflammatory cytokine production was noted in patients with TRS. Based on this, single nucleotide variants (SNVs), their influence on the expression of pro- and anti-inflammatory cytokine genes, as well as their predictor role in the development of TRS. The most promising SNVs for further studies were identified. Conclusion: The risk of developing TRS is associated with a genetically determined status of the cytokine response and its regulation. Studies of the association of various SNVs of genes encoding pro-inflammatory cytokines in the Russian Federation need to be continued.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%