Biomarkers of skin aging

Kanaki, Theodora; Makrantonaki, Evgenia; Zouboulis, Christos C.

doi:10.1007/s11154-016-9392-x

Cited by 37 publications

(25 citation statements)

References 103 publications

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“…Moreover, other factors, like less oxidized lipids and proteins of connective tissue, better efficiency of biosynthesis of endogenous collagen and proteoglycans, could also be responsible for the skin moisture level in young women, while the factors are less effective in the oldest [12, 13]. Opposite results were obtained for women on the 25th day of the cycle.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Jabłońska¹,

Mielicki

2019

Skin Pharmacol Physiol

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Background/Aims: Analysis of the relationship between the estradiol blood concentration and the skin moisture, pore width, discoloration and smoothness in differently aged women on the 5th and 25th days of the menstrual cycle. Methods: The study involved 57 women divided into 4 age groups. Measurements of skin moisture, pore width, discoloration and smoothness were performed using the Aramo SG Aram Huvis device. The estradiol serum concentration was determined by radioimmunoassay. Results: In the luteal phase of the cycle, facial skin moisture increases from 93.5% of the correct standard moisture index in the youngest to 115.5% in the oldest group. A positive correlation (r² = 0.45) between estradiol concentration and skin moisture was observed on the 5th day of the cycle in 40- to 50-year-olds. For women on the 25th day of the menstruation cycle, estrogen concentration below the normal range was more beneficial for skin smoothness and pore width for the oldest group. The difference was not statistically significant (p > 0.05); however, in the 40- to 50-year age group, skin smoothness was much better (43.5 ± 6.7%) for low estradiol while it was 37.5 ± 4.7% in the 20- to 29-year age group. Similarly, in the 40- to 50-year age group, skin pore width was much smaller (35.2 ± 15.7%) for low estradiol while it was 54.3 ± 28.8% in the 20- to 29-year age group. Conclusions: Skin moisture was related to the concentration of estradiol only in the oldest examined group of women regardless of the phase of menstrual cycle. In the 40- to 50-year-old group of women, the low level of estradiol on the 25th day of the cycle is better used to maintain a good facial skin appearance and has a positive influence not only on skin moisture, but also on pore width and skin smoothness.

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Section: Resultsmentioning

confidence: 99%

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Jabłońska¹,

Mielicki

2019

Skin Pharmacol Physiol

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“…While we have focused on molecular biomarkers of aging, our results apply to non-molecular markers as well. Indeed, the most commonly used non-molecular markers of aging, such as grip strength or skin elasticity (45, 46), are non-causal.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers for aging identified in cross-sectional studies tend to be non-causative

Nelson

Promislow

Masel

2019

Preprint

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Biomarkers are important tools for diagnosis, prognosis, and identification of the causal factors of physiological conditions. Biomarkers are typically identified by correlating biological measurements with the status of a condition in a sample of subjects. Cross-sectional studies sample subjects at a single timepoint, while longitudinal studies follow a cohort through time. Identifying biomarkers of aging is subject to unique challenges. Individuals who age faster have intrinsically higher mortality rates and so are preferentially lost over time, in a phenomenon known as cohort selection. In this paper, we use simulations to show that cohort selection biases cross-sectional analysis away from identifying causal loci of aging, to the point where cross-sectional studies are less likely to identify loci that cause aging than if loci had been chosen at random. We go on to show this bias can be corrected by incorporating correlates of mortality identified from longitudinal studies, allowing cross sectional studies to effectively identify the causal factors of aging.

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“…3 At a macroscopic level, skin aging is characterized by the progressive appearance of wrinkles, dermal atrophy due to collagen loss, degeneration in the elastic fiber network, and loss of hydration and radiance. 4 These alterations are linked to molecular, cellular, and tissue modifications of the dermis such as the reduction in the size and number of fibroblasts with substantial matrix remodeling, resulting from both a reduced production of matrix proteins and an increase in their degradation by metalloproteinases. 5,6 A causal link between nutrition and skin quality is strongly supported by the fact that cutaneous injuries such as dermatitis and depigmentation appear in some nutritional deficiencies.…”

Section: Introductionmentioning

confidence: 99%

Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo‐controlled clinical trial in women and an ex vivo study on human skin explant

Boisnic¹,

Kéophiphath²,

Sérandour³

et al. 2019

J of Cosmetic Dermatology

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Background Polar lipids from wheat (Triticum vulgare/aestivum) extract oil (WEO) are known to improve skin hydration. Aims These studies aimed to assess WEO benefits on the skin appearance of middle‐aged women. Methods A double‐blind, randomized, placebo‐controlled clinical study was carried out on 64 healthy women, aged from 45 to 60 years, to investigate antiaging effects and benefits for the skin. The study lasted 20 weeks including 12 weeks of oral supplementation with WEO or placebo and 8 weeks of follow‐up. Wrinkles in the “crow's‐feet” area were evaluated by the Lemperle score. Skin hydration was measured using a corneometer, while roughness and radiance were determined by clinical scoring. Collagen content was quantified in human skin explants exposed to ultraviolet (UV) irradiations and treated with WEO or vehicle control. Results Compared to the placebo group, the Lemperle score was significantly reduced in the WEO group between W0 and W8 to reach a clinically significant 1 grade at W12. Facial hydration was significantly improved in the WEO group from W0 to W12, whereas leg hydration was significantly increased after 4 weeks and lasted throughout the supplementation period. Skin roughness and radiance were also significantly improved from W0 to W8 in the WEO group compared to placebo group. A higher collagen content was measured in the UV‐irradiated skin explants treated with WEO compared to the untreated ones. Conclusion These results confirmed the moisturizing effect of WEO and, for the first time, revealed its potential antiaging properties.

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Biomarkers of skin aging

Cited by 37 publications

References 103 publications

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Biomarkers for aging identified in cross-sectional studies tend to be non-causative

Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo‐controlled clinical trial in women and an ex vivo study on human skin explant

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