Biomarkers of Sepsis-Induced Acute Kidney Injury

Wang, Kaifei; Xie, Sheling; Xiao, Kun; Peng, Yan; He, Wanxue; Xie, Lixin

doi:10.1155/2018/6937947

Cited by 48 publications

(38 citation statements)

References 73 publications

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“…A recent comprehensive review of the available experimental evidence has shown that different biomarkers have clearly been demonstrated as indicating varying injury mechanisms and can be used in early diagnosis for sepsis-induced acute kidney injury [55].…”

Section: Biomarkers In Sepsismentioning

confidence: 99%

Lipidomic profile and candidate biomarkers in septic patients

2020

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Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are used for diagnosis and to access sepsis prognosis and they can help in clinical decision-making, but none has sufficient specificity or sensitivity to be routinely employed in clinical practice. This review seeks to evaluate lipid metabolism alterations in patients with sepsis and the possibility of using the respective metabolites as biomarkers of the disease. A search of the main electronic biomedical databases was conducted for the 20-year period ending in February 2020, focused on primary research articles on biomarkers in sepsis. The keywords included sepsis, septic shock, biomarker, metabolomic, lipidomic and lysophosphatidylcoline.. It concludes that altered lipid profiles, along with the progress of the disease should provide new insights, enabling a better understanding of the pathogenic mechanisms and making it possible to design new early diagnosis and therapeutic procedures for sepsis.

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Section: Biomarkers In Sepsismentioning

confidence: 99%

Lipidomic profile and candidate biomarkers in septic patients

2020

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“…Sepsis is the most common condition associated with AKI in critically ill patients, accounting for 50% or more of cases of AKI in ICU settings. 40 Sepsis-induced AKI is strongly associated with increased mortality and adverse outcomes. An early diagnosis will allow for appropriate and timely interventions that may contribute to improve renal recovery and global outcomes of patients.…”

Section: Sepsismentioning

confidence: 99%

<p>Evaluating Nephrocheck<sup>®</sup> as a Predictive Tool for Acute Kidney Injury</p>

Nalesso¹,

Cattarin²,

Gobbi³

et al. 2020

IJNRD

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Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short-and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] x [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management.

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“…Septic shock is one of the most common causes of acute kidney injury (AKI) [2]. The mortality rate of sepsis is increased with AKI to up to 50-60% [4]. Therefore, an approach to promptly identify the source of infection in order to provide early treatment is needed [5].…”

Section: Introductionmentioning

confidence: 99%

Successful treatment of direct hemoperfusion with polymyxin B-immobilized fiber for septic shock and severe acute kidney injury due to ceftriaxone-resistant Escherichia coli: a case report with literature review

Shima¹,

Kimura²,

Nishiuchi³

et al. 2020

Ren Replace Ther

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Background: Septic shock is a life-threatening condition and one of the most common causes of acute kidney injury. Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is used to reduce endotoxin levels in blood. Here, we report a rare but important case of sepsis-induced acute kidney injury and septic shock, which was successfully treated with PMX-DHP in spite of inappropriate initial antibiotic therapy. Case presentation: An 84-year-old man was hospitalized for septic shock and acute kidney injury. Although he was treated with ceftriaxone, he did not recover from hypotension and had reduced urine output. After initiating PMX-DHP on days 3 and 4, his blood pressure was immediately elevated and his white blood cell count and Creactive protein levels improved. Because ceftriaxone-resistant Escherichia coli was identified in blood culture, we changed his antibiotics to levofloxacin on day 7. He successfully recovered from the septic shock and dialysis was withdrawn. Conclusions: Considering the use of inappropriate initial antibiotics, the early induction of PMX-DHP might have been a key determinant of his outcome. PMX-DHP therapy should be considered in septic shock in addition to antibiotic treatment.

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Biomarkers of Sepsis-Induced Acute Kidney Injury

Cited by 48 publications

References 73 publications

Lipidomic profile and candidate biomarkers in septic patients

Lipidomic profile and candidate biomarkers in septic patients

<p>Evaluating Nephrocheck<sup>®</sup> as a Predictive Tool for Acute Kidney Injury</p>

Successful treatment of direct hemoperfusion with polymyxin B-immobilized fiber for septic shock and severe acute kidney injury due to ceftriaxone-resistant Escherichia coli: a case report with literature review

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