Biomarkers of placental redox imbalance in pregnancies with preeclampsia and consequent perinatal outcomes

Ferreira, Raphaela Costa; Fragoso, Marilene Brandão Tenório; Tenório, Micaely Cristina dos Santos; Martins, Amylly Sanuelly da Paz; Borbely, Alexandre Urban; Moura, Fabiana Andréa; Goulart, Marília Oliveira Fonseca; Oliveira, Alane Cabral Menezes de

doi:10.1016/j.abb.2020.108464

Cited by 9 publications

(15 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In view of the above and comparing the findings of the present study with the previous study carried out by our group on placentas of PE women [12], it is possible to observe that the reduced levels of IL-6 in the umbilical cord of pregnancies with PE, as well as the increase of this cytokine in placentas, indicate the accumulation of IL-6 in the placenta for foetal protection. On the other hand, TNF-α was reduced in the umbilical cord of PE pregnancies; however, in placentas, there were no differences between the PE and without PE groups.…”

Section: Discussionsupporting

confidence: 84%

“…Corroborating with these findings, in a recent study carried out by our group in PE placentas from the same population herein studied, a positive (beneficial) association was 13 Oxidative Medicine and Cellular Longevity observed between placental GSH levels and birth weight, HC, CC, and gestational age at birth [12]. In other words, the higher the placental GHS levels, the better the perinatal outcomes of conceptuses from pregnancies with PE.…”

Section: Discussionsupporting

confidence: 83%

“…The presence of oxida-tive stress in the umbilical cord during PE was revealed by the increased level of MDA in comparison to the group without PE. GSH plays a beneficial role in the health of the foetus, as demonstrated previously in the placenta, where higher levels of GSH in PE placentas positively influenced birth weight, HC, CC, and gestational age at birth, which might be a compensation mechanism against oxidative stress [12]. However, data on this topic are still controversial.…”

Section: Discussionmentioning

confidence: 84%

“…35743614.1.0000.5013). It is important to mention that an article has already been published containing the data referring to the placenta analysis by our research group [ 12 ] and that this study used the same PE women, women without the disease, and their newborns [ 12 ]. Their umbilical cords are herein analysed for the first time.…”

Section: Methodsmentioning

confidence: 99%

“…As a consequence, hypoxia/reperfusion occurs in the organ, which leads to high production of reactive oxygen species (ROS), leading to oxidative stress in addition to inflammation and endothelial dysfunction. Such changes culminate in the occurrence of adverse perinatal outcomes, such as IUGR, premature birth, newborns small for gestational age, and other complications, including maternal and foetal deaths [8][9][10][11][12]. It is also important to highlight that redox homeostasis depends on a number of factors, including gender, age, disease, and pregnancy, emphasizing, therefore, that PE is a factor able to interfere in this redox homeostasis [9,13].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Biomarkers of Inflammation and Redox Imbalance in Umbilical Cord in Pregnancies with and without Preeclampsia and Consequent Perinatal Outcomes

Fragoso

Ferreira

Tenório

et al. 2021

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Objective. To compare redox imbalance and inflammation biomarkers in umbilical cords from pregnancies with and without preeclampsia (PE) and to analyse their relationships with perinatal outcomes. Methods. A controlled cross-sectional study was conducted in Maceió, Alagoas, Brazil, that involved pregnant women with PE and a group of women without the disease, through the application of a standardized questionnaire. After delivery, umbilical cord samples were collected to measure antioxidant defense, products from oxidative damage, and inflammation biomarkers such as myeloperoxidase (MPO), interleukin- (IL-) 6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α). Statistical analyses were performed using Stata version 13.0 software and IBM Statistical Package for the Social Sciences (SPSS) 20.0, adopting a 95% confidence level ( α = 0.05 ), with the chi-square test, the Wilcoxon–Mann–Whitney test, and the multinomial and Poisson regression tests. Results. One hundred PE pregnant women and 50 women without the disease were studied. The umbilical cords from PE pregnancies showed higher levels of reduced glutathione (GSH) ( p ≤ 0.001 ), glutathione peroxidase (GPx) ( p = 0.016 ), and malondialdehyde (MDA) ( p = 0.028 ) and lower levels of IL-6 ( p = 0.030 ) and TNF-α ( p ≤ 0.001 ) than the other group, with some associations among these biomarkers with perinatal outcomes. Conclusion. The higher levels of GSH and GPx, in addition to the lower levels of IL-6 and TNF-α, found in the PE umbilical cord, may result from adaptive mechanisms to maintain the oxidative and inflammatory balance; however, despite these changes, the damage to the cell membranes was not minimized, as the MDA level was higher in women with PE than in women without the disease. This implies that a redox imbalance is present, confirming that other physiological and adaptive mechanisms are being activated to preserve foetal health. Therefore, the present work unveils an important role of the umbilical cord in controlling redox imbalance and inflammation in PE pregnancies. Our results reinforce the necessity for continuous research on GSH as a protective compound for the perinatal outcome, especially in PE women.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%