Biomarkers of oxidative stress in amniotic fluid and complications in pregnancy

Bogavac, Mirjana; Lakic, Neda; Simin, Nataša; Nikolić, Aleksandra; Sudji, Jan; Božin, Biljana

doi:10.3109/14767058.2011.560625

Cited by 22 publications

(20 citation statements)

References 19 publications

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“…In particular, the abundance of reactive oxygen species and lipid peroxidation products, together with a reduced antioxidant activity, play a key role in the development of hypertension and preeclampsia during the gestational period, with a potential increased risk of adverse outcomes in pregnancy [26]. Since GST enzymes are in the main superfamily of Phase II enzymes, different biochemical studies investigated these enzymes in terms of gestational hypertension and other related phenotypes [27]. The investigation of the GSTA1 enzyme yielded the most interesting findings, indicating significant differences between hypertensive pregnant women and healthy pregnant women, and significant correlations of GSTA1 levels with inflammation and hepatocellular damage in pregnant hypertensive women [17].…”

Section: Discussionmentioning

confidence: 99%

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

Iorio

Spinelli

Polimanti

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Discussionmentioning

confidence: 99%

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

Iorio

Spinelli

Polimanti

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…[18] However, Bogavac et al found contradicting results that MDA levels were low in amniotic fluid of women with preeclampsia. [19] We noted concentrations of MDA and XOD in women with complicated pregnancies were similar to those with normal pregnancies, which is not in correlation with alteration of oxidative stress in the pregnancies with preeclampsia. [18,19] Additionally, levels of SOD, intracellular enzyme of antioxidative defense, remain alike in the women with complicated pregnancies, which is in agreement with the previous study.…”

Section: Discussionmentioning

confidence: 61%

Investigation of the relationship between levels of oxidative stress markers in the second trimester amniotic fluid with preeclampsia and preterm delivery

Çelik¹

2012

Perinatal J

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Objective: To determine whether concentrations of oxidative stress markers of amniotic fluid are different in healthy pregnant women from pregnant women with either preeclampsia or preterm birth before 34 weeks gestation. Methods: This was a retrospective cohort study consisting of consecutive 182 pregnant women with singleton gestations undergoing midtrimester amniocentesis for clinical indications (advanced maternal age, abnormal screening tests for trisomies or maternal request) in ‹nonü University, Turgut Özal Research Center between April 2011 and May 2012. Patients were invited to donate amniotic fluid for research purposes. The pregnancy outcome was collected by reviewing the charts of hospital or by contacting the patients. Exclusion criteria from the study were: (i) incomplete data about the outcome of pregnancy, (ii) confirmed fetal abnormalities or chromosomal abnormalities, (iii) presence of intrauterine infection, (iv) maternal systemic diseases such as chronic hypertension or diagnosis of gestational diabetes mellitus. Amniotic fluid samples were obtained by transabdominal amniocentesis and 4-5 mL was collected for research purposes. Amniotic fluid samples were stored at-80°C for the future analysis. Diagnosis of preeclampsia was made according to the criteria of International Society for the Study of Hypertension in Pregnancy. Results: The mean amniotic fluid concentrations of SOD, ADA, MPO, XO and MDA were not different in the preeclamptic group from the control group. Further, the mean concentrations of SOD, ADA, MPO, XO and MDA in the preterm group were also similar to those in the normal healthy pregnant women. Conclusion: The oxidative stress markers appear not to be different among the groups. The relation of preterm birth and preeclampsia with oxidative stress and its implication in amniotic environment need to be addressed in further studies.

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“…GR is another marker of oxidative stress. This enzyme is expressed when the oxidative insult exceeds the threshold value (Bogavac et al , 2012). The TBARS levels in blood corresponded with our expectation that HI-6 was implicated in oxidative stress generation (Pohanka, 2011, 2012).…”

Section: Discussionmentioning

confidence: 99%

Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)

Pohanka

Sobotka

Svobodová

et al. 2013

Interdisciplinary Toxicology

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Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment based on administration of an antidote. In this study, Wistar rats were exposed to SM in doses of 0–40 mg/kg body weight and treated with the compound HI-6. The treatment provided no significant effect on ferric reducing antioxidant power of blood and plasma. However, HI-6 caused an increase in the level of thiobarbituric acid reactive substances. This stressogenic response was presumably the cause of the significant elevation of the blood level of both glutathione reductase and reduced glutathione. HI-6 appears to be suitable for enhancing prophylactically oxidative stress protection from small oxidative insult.

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Biomarkers of oxidative stress in amniotic fluid and complications in pregnancy

Abstract: Parameters of oxidative stress in amniotic fluid could be altered in certain pathological conditions. Their use as clinical biomarkers is limited due to great variations of amniotic fluid volume between patients which gives favor to hemolysate or serum of pregnant women.

Cited by 22 publications

References 19 publications

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

Investigation of the relationship between levels of oxidative stress markers in the second trimester amniotic fluid with preeclampsia and preterm delivery

Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)

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