Biomarkers of oxidative stress in women with pre-eclampsia

Siddiqui, Imran; Jaleel, Anila; Al-Kadri, Hanan M.; Akram, Sufyan; Tamimi, Waleed

doi:10.2217/bmm.12.109

Cited by 17 publications

(8 citation statements)

References 25 publications

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“…Vitamin E supplementation (400 IU daily) improved endometrial response during controlled ovarian stimulation in women with unexplained infertility [ 42 ]. Finally, pre-eclampsia is associated with significantly lower serum vitamin E levels [ 43 ]. More research is needed to understand the role of vitamin E status on reproductive success in men and women.…”

Section: Discussionmentioning

confidence: 99%

Suboptimal Serum α-Tocopherol Concentrations Observed among Younger Adults and Those Depending Exclusively upon Food Sources, NHANES 2003-20061-3

McBurney¹,

Ciappio³

et al. 2015

PLoS ONE

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Vitamin E is an essential nutrient for human health, with an established function as a lipid-soluble antioxidant that protects cell membranes from free radical damage. Low vitamin E status has been linked to multiple health outcomes, including total mortality. With vitamin E being identified as a ‘shortfall nutrient’ because >90% of American adults are not consuming recommended amounts of vitamin E, we aimed to determine the prevalence of both clinical vitamin E deficiency (serum α-tocopherol concentration < 12 μmol/L) and failure to meet a criterion of vitamin E adequacy, serum α-tocopherol concentration of 30 μmol/L, based on the Estimated Average Requirement (EAR) and lowest mortality rate in the Alpha-Tocopherol Beta-Carotene (ATBC) study. The most recent nationally-representative cross-sectional data (2003–2006) among non-institutionalized US citizens with available serum concentrations of α-tocopherol from the National Health and Nutrition Examination Survey (NHANES); Centers for Disease Control and Prevention were analyzed. Serum α-tocopherol distributions were compared between those reporting consumption of food without supplement use (FOOD) and food and supplement use (FOOD+DS) by sex, age, and race/ethnicity. Only 1% of the US population is clinically deficient. FOOD consumers have lower average α-tocopherol levels (24.9± 0.2 μmol/L) than FOOD+DS users (33.7 ± 0.3 μmol/L), even when adjusted for total cholesterol. Using a criterion of adequacy of 30 μmol/L, 87% of persons 20-30y and 43% of those 51+y had inadequate vitamin E status (p<0.01). A significant greater prevalence of FOOD compared to FOOD+DS users did not meet the criterion of adequacy which was based on the EAR and low ATBC mortality rate consistently across age, sex, and race/ethnic groups. The prevalence of inadequate vitamin E levels is significantly higher among non-users of dietary supplements. With declining usage of vitamin E supplements, the population should be monitored for changes in vitamin E status and related health outcomes.

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Section: Discussionmentioning

confidence: 99%

Suboptimal Serum α-Tocopherol Concentrations Observed among Younger Adults and Those Depending Exclusively upon Food Sources, NHANES 2003-20061-3

McBurney¹,

Ciappio³

et al. 2015

PLoS ONE

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“…A biomarker, or biological marker, is in general a substance used as an indicator of a biological state. It is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention [ 18 , 19 ]. Biomarkers can therefore be substances in the body that may indicate risk or the presence of disease [ 20 , 21 ].…”

Section: Biomarkers For Monitoring Healthmentioning

confidence: 99%

Sperm Parameters: Paradigmatic Index of Good Health and Longevity

Omu¹

2013

Med Princ Pract

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Since the discovery of spermatozoon by Anton van Leeuwenhoek in 1677, there has been an ever increasing understanding of its role in reproduction. Many factors adversely affect sperm quality, including varicocele, accessory gland infection, immunological factors, congenital abnormalities, and iatrogenic systemic and endocrine causes, such as diabetes mellitus, obesity, metabolic syndrome, and smoking. The mechanisms responsible for the association between poor sperm parameters and ill health may include oxidative stress, low-grade inflammation, low testosterone, and low sex-hormone-binding globulin. Oxidative stress in the testicular microenvironment may result in decreased spermatogenesis and sperm DNA damage, loss of sperm motility, and abnormal sperm morphology. Low testosterone caused by advanced age, visceral obesity, and inflammation is associated with the development of cardiovascular disease. Hence, semen analysis has an important role in the routine evaluation of idiopathic male infertility, usually manifested as low sperm counts, impaired sperm motility, or absence of sperm, and remains the most common single diagnostic tool. Several studies have shown an inverse relationship between semen quality and medical disorders. This review elucidates the effect of medical disorders and social habits on sperm quality, the mechanisms that are involved in the impairment of sperm quality, and whether or not sperm quality can be used as an index of good health and longevity in a man.

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“…Because, generalized vasoconstriction and oxidative stress that cause endothelial injuries are full markings in the pathogenesis of PE [23,24]. Based on the current findings, no significant difference was observed in protective actions among the two extracts.…”

Section: Discussionmentioning

confidence: 59%

Protective Effects of Thymus schimperi and Moringa stenopetala Leaf Extracts on Arterial Blood Pressure and Urine Protein Level in Pre-eclampsia Rat Models

Mergiaw

Mengesha

Tolessa

et al. 2020

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Background: Pre-eclampsia (PE) is a common hypertensive disorder during pregnancy and one of the leading causes of perinatal mortality and morbidity. There is no curative modern drug to treat PE. Therefore, researches done on traditional medications have paramount importance in discovering therapeutic and /or protective agents from plant materials. In Ethiopia, there are claims that some indigenous medicinal plants such as Thymus and Moringa can have potential protective functions against PE. The aim of this study was to prove the claims. Methods: Experiments were performed to investigate the effects of aqueous leaf extracts of Thymus schimperi (ALETS) and Moringa stenopetala (ALEMS) on PE rat models induced by nitro-L-arginine methyl ester (L-NAME); a nitric oxide synthase inhibitor. A non-invasive tail cuff blood pressure recorder (Model 179 Amplifier, IITC INC, Life Science Instruments, Woodland Hills, California) was used to determine the arterial blood pressure from rat tail. Urine analysis to determine protein levels was performed using a dipstick, semi-qualitative method as per manufacturer’s instructions (CYBO DFI Korea). Results: ALETS treated PE rat models showed significantly reduced mean arterial blood pressure (MAP) in mmHg; 108±3 (P<0.05), 105±1 (P<0.01) and 99±2 (P<0.01); also the same pattern of results were seen in ALEMS treated PE groups with MAP of 106±1 (P<0.05), 103±1 (P<0.05) and 101±1 (P<0.05) at daily doses of 250 mg/kg, 500 mg/kg and 1000 mg/kg, respectively, compared to untreated case group that had 123±3.7 mmHg at gestation day (GD) 19 . Untreated PE rat models showed significant proteinuria (2000±20 mg/L) throughout the gestation period; while PE rat models treated with either ALETS or ALEMS had significantly reduced (p<0.05) proteinuria in dose dependent pattern (150±15 mg/L) at a dose of 1 gm/kg for each plant extract at GD 19. Conclusion: Aqueous leaf extracts of either Thymus schimperi or Moringa stenopetala might reduce and control arterial pressure in PE rat models in a dose dependent manner. The extracts also could reduce level of proteinuria in the same pattern. Further investigation should, however, be carried out to confirm their uses in prevention and/or treatment of pregnancy-induced hypertension among human cases.

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Biomarkers of oxidative stress in women with pre-eclampsia

Abstract: MDA, vitamin E and blood total glutathione are possible candidate markers to predict pre-eclampsia.

Cited by 17 publications

References 25 publications

Suboptimal Serum α-Tocopherol Concentrations Observed among Younger Adults and Those Depending Exclusively upon Food Sources, NHANES 2003-20061-3

Suboptimal Serum α-Tocopherol Concentrations Observed among Younger Adults and Those Depending Exclusively upon Food Sources, NHANES 2003-20061-3

Sperm Parameters: Paradigmatic Index of Good Health and Longevity

Protective Effects of Thymus schimperi and Moringa stenopetala Leaf Extracts on Arterial Blood Pressure and Urine Protein Level in Pre-eclampsia Rat Models

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