Biomarkers of Oxidative Stress Associated with the Risk of Potentially Malignant Oral Disorders

Senghore, Thomas; LI, YU-FENG; Sung, Fung‐Chang; Tsai, Ming‐Hsui; Hua, Chun‐Hung; LIU, CHIU-SHONG; HUANG, RU-JIUN; Yeh, Chih‐Ching

doi:10.21873/anticanres.12844

Cited by 14 publications

(8 citation statements)

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“…8-OHdG is the most used biomarker for free radical induced DNA damage, and it has been reported as a good biomarker for risk assessment of cancer . HNE–MA is a metabolite of lipid peroxidation product 4-hydroxy-2-nonenal (HNE), a cytotoxic and mutagenic signaling molecule that regulates cell cycle and forms DNA adducts leading to DNA damage. ,, Urine levels of 8-isoPF 2α is a biomarker for arachidonic acid peroxidation, and has been associated with increased risk of potential malignant oral disorders and breast cancer progression. , 8-NO 2 Gua is formed from DNA damage induced by RNS generated under inflammatory conditions, and reported to participate in carcinogenesis . Serum levels of 31 acylcarnitines in 107 study subjects were analyzed using UHPLC–MS.…”

Section: Methodsmentioning

confidence: 99%

Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants

Chen

Kuo

et al. 2019

Environ. Sci. Technol.

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Studies on metabolomes of carcinogenic pollutants among children and adolescents are limited. We aim to identify metabolic perturbations in 107 children and adolescents (aged 9–15) exposed to multiple carcinogens in a polluted area surrounding the largest petrochemical complex in Taiwan. We measured urinary concentrations of eight carcinogen exposure biomarkers (heavy metals and polycyclic aromatic hydrocarbons (PAHs) represented by 1-hydroxypyrene), and urinary oxidative stress biomarkers and serum acylcarnitines as biomarkers of early health effects. Serum metabolomics was analyzed using a liquid chromatography mass spectrometry-based method. Pathway analysis and “meet-in-the-middle” approach were applied to identify potential metabolites and biological mechanisms linking carcinogens exposure with early health effects. We found 10 potential metabolites possibly linking increased exposure to IARC group 1 carcinogens (As, Cd, Cr, Ni) and group 2 carcinogens (V, Hg, PAHs) with elevated oxidative stress and deregulated serum acylcarnitines, including inosine monophosphate and adenosine monophosphate (purine metabolism), malic acid and oxoglutaric acid (citrate cycle), carnitine (fatty acid metabolism), and pyroglutamic acid (glutathione metabolism). Purine metabolism was identified as the possible mechanism affected by children and adolescents’ exposure to carcinogens. These findings contribute to understanding the health effects of childhood and adolescence exposure to multiple industrial carcinogens during critical periods of development.

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Section: Methodsmentioning

confidence: 99%

Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants

Chen

Kuo

et al. 2019

Environ. Sci. Technol.

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“…Protein modifications by oxidative stress result in the loss of their functions and may render proteins more prone to proteolytic degradation [26]. ROS and RNS can contribute also to oxidative damage to lipids and nucleic acids [27–29]. Lipid hydroperoxides, acrolein, malondialdehyde (MDA), and 4-hydroxy-2-nonenal (HNE) are useful biomarkers of oxidative stress to lipids [28, 29].…”

Section: Oxidative Stress: Role Of Reactive Oxygen Species (Ros) Amentioning

confidence: 99%

“…ROS and RNS can contribute also to oxidative damage to lipids and nucleic acids [27–29]. Lipid hydroperoxides, acrolein, malondialdehyde (MDA), and 4-hydroxy-2-nonenal (HNE) are useful biomarkers of oxidative stress to lipids [28, 29]. Therefore, in conditions characterized by an imbalance between ROS/RNS levels and antioxidants, oxidative cell injury may occur and trigger oxidation of lipids, proteins, and DNA.…”

Section: Oxidative Stress: Role Of Reactive Oxygen Species (Ros) Amentioning

confidence: 99%

“…RNS like ROS can directly damage the molecule DNA, while inhibiting its repair. The formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG), oxidative damage to guanine (G), is the most common form of oxidative DNA damage [29, 56]. This base modification increases by 35–50% in individuals using tobacco smoke, a well-known carcinogenic source of ROS [57].…”

Section: Markers Of Lipid Protein and Nucleic Acid Oxidative Strmentioning

confidence: 99%

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Alterations of Antioxidant Enzymes and Biomarkers of Nitro-oxidative Stress in Tissues of Bladder Cancer

Islam

Bacchetti

Ferretti

2019

Oxidative Medicine and Cellular Longevity

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Bladder cancer (BC) is one of the most common tumors found in the urinary bladder for both male and female in western countries. In vitro and in vivo studies suggest that high levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and oxidative stress play a crucial role in human cancer. Low concentration of ROS and RNS is indispensable for cell survival and proliferation. However, high concentration of ROS and RNS can exert a cytotoxic effect. Increased oxidative stress is a result of either increased ROS/RNS production or a decrease of antioxidant defense mechanisms. A literature search was carried out on PubMed, Medline, and Google Scholar for articles in English published up to May 2018 using the following keywords: oxidative stress, antioxidants, reactive oxygen species, lipid peroxidation, paraoxonase, urinary bladder cancer, and nitric oxide. Literature data demonstrate that BC is associated with oxidative stress and with an imbalance between oxidants and antioxidant enzymes. Markers of lipid peroxidation, protein and nucleic acid oxidation are significantly higher in tissues of patients with BC compared with control groups. A decrease of activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione, and paraoxonase) has also been demonstrated. The imbalance between oxidants and antioxidants could have a potential role in the etiology and progression of bladder cancer.

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“…[ 12 ] Various studies have been successful in establishing the association between the development and progression of oral premalignancy and malignancy with the oxidant–antioxidant imbalance in different biological samples, including tissue, serum, and saliva. [ 10 13 14 15 16 17 ] The end products of lipid peroxidation have shown to increase the free radical production further. Eventually, these entities cause mutations in the essential regulatory genes, thus contributing to oral carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

A case-control study comparing and correlating iNOS expression among various clinicopathological variants of oral leukoplakia and oral squamous cell carcinoma: A Immunohistochemistry study

et al. 2020

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A BSTRACT Background and Objective: The role of inducible nitric oxide synthase (iNOS) has been implicated in various pathological processes including oral carcinoma. Oral premalignancy being its precursor lesion is also expected to show similar pattern. This study attempts to appraise the iNOS expression in various clinicopathological stages and grades of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). Materials and Methods: A case-control study design was adopted for this study with a total sample of 90 subjects, distributed equally into the three study groups, namely controls, OL, and OSCC. Clinical staging and histopathological grading for both the case groups were performed. Representative tissue samples from all groups were obtained and studied for iNOS expression using immunohistochemistry (IHC). Data were presented in mean and percentages accordingly. Inferential analysis was performed using Kruskal–Wallis test, Mann–Whitney test, and Spearman rank correlation test. Results: Significant ( P < 0.001) difference was observed among the groups, where 83.3% of OSCC and 73.3% of OL epithelial cells showed iNOS expression. The normal cells did not show up any expression. The expression was found to rise with the progressing clinical stages of OL ( P < 0.05) and OSCC ( P < 0.01). Similar pattern was observed with respect to advancing dysplasia in OL ( P < 0.01) and cell differentiation in OSCC ( P < 0.01). Significant positive correlation was found in clinicopathological categories of OL and OSCC. Considering the risk assessment, iNOS staining was found to be significantly raised in advanced cases of OSCC ( P < 0.01) and high-risk cases of OL ( P < 0.01). Conclusion: Increased expression of iNOS can be an early diagnostic marker in OL and as prognostic marker in OSCC.

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Biomarkers of Oxidative Stress Associated with the Risk of Potentially Malignant Oral Disorders

Abstract: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.

Cited by 14 publications

References 1 publication

Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants

Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants

Alterations of Antioxidant Enzymes and Biomarkers of Nitro-oxidative Stress in Tissues of Bladder Cancer

A case-control study comparing and correlating iNOS expression among various clinicopathological variants of oral leukoplakia and oral squamous cell carcinoma: A Immunohistochemistry study

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