Biomarkers of oxidative stress and DNA damage in agricultural workers: A pilot study

Muñiz, Juan; McCauley, Linda; Scherer, Jennifer; Lasarev, Michael; Koshy, Mary; Kow, Yoke W.; Nazar-Stewart, Valle; Kisby, Glen E.

doi:10.1016/j.taap.2007.10.027

Cited by 178 publications

(106 citation statements)

References 60 publications

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“…A study from our group observed shortening telomeres in individuals occupationally chronically exposed to low doses of pesticides at tobacco farms [33], in addition to various kinds of DNA damages already found in those individuals [81][82][83][84], corroborated by several other studies [85,86]. Pesticides are known for inducing oxidative stress [33,82,87,88], and although not all action mechanism of these chemicals are clear, induction of oxidative stress and of ROS seems to be involved.…”

Section: Occupational and Environmental Exposuressupporting

confidence: 59%

Telomere Length and Its Relation to Human Health

Kahl¹,

Silva²

2016

Telomere - A Complex End of a Chromosome

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Telomeres are complex nucleotide sequences that cap the end of chromosomes from degradation, unwanted recombination-fusion, inappropriate activation of DNA damage response and play a critical role in cell division and chromosome stability. There is growing evidence that telomere stability can be affected by occupational and environmental exposure, as some of these factors have been correlated with increase in inflammation, oxidative stress, DNA damage, chromosome aberration, and epigenetic alterations. Both extremely short and long telomeres have been associated with neurodegenerative, cardiovascular diseases (CVD) and cancer risk. Occupational and environmental exposure to several synthetic and natural chemicals has been found to be associated with changes in telomere length, although the molecular mechanism is not fully understood. Telomeric DNA is relatively less capable of repair, resulting in accelerated shortening during the cell cycle and replicative senescence. It is recognized that diet plays an important role in telomere maintenance. Prevention of exposure to environmental and occupational hazards as well as psychological stressors can reduce the risk of telomere instability. This review provides a broad evaluation of the associated mechanism between human health and environmental and occupational exposure with telomere length, including recent findings and future perspectives.

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Section: Occupational and Environmental Exposuressupporting

confidence: 59%

Telomere Length and Its Relation to Human Health

Kahl¹,

Silva²

2016

Telomere - A Complex End of a Chromosome

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“…Several studies reveal that OPs may induce oxidative stress leading to generation of free radicals and alteration of antioxidant status (Bagchi, 1995;Abdhollahi, 2004). Toxic effects of pesticide on human beings especially by omitting radical production can be confirmed by the direct measurement of lipid per oxidation by-product malondialdyhyde (MDA), (Muniz et al, 2007). Our study revealed a significant rise in Plasma malondialdehyde (MDA) levels in exposed farmers than in controls.…”

Section: Oxidative Stresssupporting

confidence: 59%

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Hashmi¹,

Imran²,

Dilshad³

2011

Pesticides - The Impacts of Pesticides Exposure

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“…23,[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] This list is not exhaustive but highlights both established markers of pesticide exposure (such as cholinesterase activity) and emerging biomarkers (such as the ''challenge assay,'' which assesses the DNA repair capacity of cells). It should be noted that most of these biomarkers are not used in the clinic at present; however, they have usefulness in research studies that aim to determine the etiology of cancers that have been linked to agrochemical exposure.…”

Section: Biomarkers Relevant To Pesticide-induced Cancersmentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

291

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Biomarkers of oxidative stress and DNA damage in agricultural workers: A pilot study

Cited by 178 publications

References 60 publications

Telomere Length and Its Relation to Human Health

Telomere Length and Its Relation to Human Health

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Increased cancer burden among pesticide applicators and others due to pesticide exposure

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