Biomarkers of Oxidative Stress and Risk of Colorectal Cancer: A Cohort-Nested Case-Control Study in the EPIC Database

Leufkens, Anke M.; Duijnhoven, Fränzel J. van; Woudt, Sjoukje H S; Siersema, Peter D.; Bueno-de-Mesquita, H. Bas

doi:10.1016/s0016-5085(11)61413-3

Cited by 2 publications

(2 citation statements)

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“…Accordingly, we and other authors observed that serum samples showed a very good degree of stability for up to 1 year of storage at -20 and -80°C [7,22]. Moreover, the positive correlation of reactive oxygen metabolites with colorectal cancer in liquid nitrogen frozen samples suggested that this biomarker is stable in long-stored samples [23].…”

Section: Diacron Reactive Oxygen Metabolites Testsupporting

confidence: 52%

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

2020

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Oxidative stress has a pivotal and widely described role in the onset and progression of atherosclerotic plaque and cardiovascular disease. Many oxidative stress-related biomarkers can be measured in biological samples; however, there are still many aspects that limit the adoption of oxidative stress assessment in clinical laboratory practice. Here, we report an overview of the different sources and main common oxidative stress biomarkers relevant for cardiovascular physiopathology, describing in detail a recently proposed lipidomic assay for ceramide assessment, as a promising future development in oxidative stress evaluation among the many available redox-related tests.

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Section: Diacron Reactive Oxygen Metabolites Testsupporting

confidence: 52%

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

2020

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“…For example, case-control studies have shown increased blood levels of oxidative stress markers in patients with familial adenomatous polyposis and colorectal cancer (151)(152)(153). However, a recent nested case-control study in EPIC suggested that the association between oxidative stress indicators, such as reactive oxygen metabolites (ROM), and colorectal cancer risk is a result of reactive oxygen species (ROS) production by preclinical tumours, rather than a causal factor in carcinogenesis (reverse causation) (154). In this study, ferric reducing ability of plasma (FRAP), another marker of oxidative stress, was not associated with colorectal cancer risk.…”

Section: Other Mechanismsmentioning

confidence: 99%

Obesity and colorectal cancer

Aleksandrova

Nimptsch²,

Pischon³

2013

Front Biosci

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This review outlines the association of obesity with risk of colorectal cancer and the potential underlying mechanisms from an epidemiological perspective. Current research indicates that there is a moderate but consistently reported association between general obesity (as determined by BMI) and colorectal cancer incidence and mortality. The relative risk associated with obesity is higher for cancer of the colon than for cancer of the rectum and it is higher in men than in women. By contrast, abdominal adiposity (as determined by waist circumference or waist-to-hip ratio) is similarly strongly associated with colon cancer in men and women, suggesting that abdominal adiposity is a more important risk factor for colon cancer than general adiposity, at least in women. Putative mechanisms that may account for the link between adiposity and colorectal cancer risk include hyperinsulinemia, insulin resistance, inflammation, altered immune response, oxidative stress, as well as disturbances in insulin-like growth factors, adipokines, and sex steroids. Understanding the link between obesity and colorectal cancer may pave the way for targeted prevention of colorectal cancer morbidity and mortality.

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Biomarkers of Oxidative Stress and Risk of Colorectal Cancer: A Cohort-Nested Case-Control Study in the EPIC Database

Cited by 2 publications

References 0 publications

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

Obesity and colorectal cancer

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