Biomarkers of oxidant stress, insulin sensitivity and endothelial activation in rheumatoid arthritis: a cross-sectional study of their association with accelerated atherosclerosis

Pemberton, Philip W.; Ahmad, Yasmeen; Bodill, Helena; Lokko, Daniel; Hider, Samantha L.; Yates, Allen P.; Walker, Michael G.; Laing, Ian; Bruce, Ian N.

doi:10.1186/1756-0500-2-83

Cited by 33 publications

(33 citation statements)

References 23 publications

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“…In another study, 46 RA patients with an average disease duration of 12 years had significantly increased levels of sVCAM and sEsel compared with healthy controls ( P = 0·029 and P < 0·001 respectively). Levels of sVCAM in this study correlated with intima media thickness (IMT) (r = 0·37, P = 0·012) [24]. These studies indicate that endothelial cell activation is present in RA.…”

Section: Methods To Detect (Preclinical) Atherosclerosis In Ramentioning

confidence: 59%

Risk factors and early detection of atherosclerosis in rheumatoid arthritis

Groot

Posthumus

Kallenberg

et al. 2010

Eur J Clin Investigation

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Section: Methods To Detect (Preclinical) Atherosclerosis In Ramentioning

confidence: 59%

Risk factors and early detection of atherosclerosis in rheumatoid arthritis

Groot

Posthumus

Kallenberg

et al. 2010

Eur J Clin Investigation

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“…Therefore, the inflammatory character of RA can explain the observed low selenium levels in the serum of patients with the disease. In a similar study, Pemberton et al [22] recently reported low levels of blood selenium in 46 RA patients. Köse et al [23] reported that plasma Se levels in 60 patients were lower than those of 60 healthy controls.…”

Section: Discussionmentioning

confidence: 87%

Effects of Different Medical Treatments on Serum Copper, Selenium and Zinc Levels in Patients with Rheumatoid Arthritis

Önal

Nazıroğlu

Çolak

et al. 2010

Biol Trace Elem Res

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The aim of the present study was to measure the changes in serum selenium, zinc, and copper in patients being treated for rheumatoid arthritis. Thirty-two patients and 52 healthy controls were included in the study. The copper level was higher and those of selenium and zinc were lower in the patients relative to controls. Treatment with methotrexate elevated the zinc levels, but not zinc and selenium. Treatments with salazopyrin, corticosteroids, chloroquine, and non-steroidal anti-inflammatory drugs did not change the levels of any of the elements studied. The decrease in zinc and selenium levels and elevation in copper levels observed in the patients probably resulted from the defense response of organism and are mediated by inflammatory-like substances.

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“…However, there were studies reporting non-significant association [19][20][21] while others supported an inverse association between selenium levels and hypertension [6,22,23]. In a cross-sectional study on 722 males with mean age 54 years old in eastern Finland higher selenium level was found to be associated with lower hypertension rate [6].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Jin

Unverzagt

et al. 2016

The Journal of nutrition, health and aging

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Objectives:Results from previous studies have been inconsistent on the association between selenium and hypertension, and very few studies on this subject have focused on the elderly population. The purpose of this study is to examine the relationship between selenium level and hypertension in a rural elderly Chinese cohort.Design: A longitudinal study was implemented and data were analyzed using logistic regression models and Cox proportional hazards regression model adjusting for potential confounders. The association between selenium level and prevalent hypertension at baseline and between selenium and incident hypertension were examined. Setting:Community-based setting in four rural areas in China.Subjects: A total of 2000 elderly aged 65 years and over (mean 71.9±5.6 years) participated in this study.Measurements: Nail selenium levels were measured in all subjects at baseline. Blood pressure measures and self-reported hypertension history were collected at baseline, 2.5 years and 7 years later. Hypertension was defined as systolic blood pressure 140 mmHg or higher, diastolic blood pressure 90 mmHg or higher, or reported use of anti-hypertensive medication. Results:The rate of baseline hypertension was 63.50% in this cohort and the mean nail selenium level is 0.413±0.183μg/g. Multi-covariate adjusted cross-sectional analyses indicated that higher selenium level was associated with higher blood pressure measures at baseline and higher rates of hypertension. For the 635 participants with normal blood pressure at baseline, 360 had developed hypertension during follow-up. The incidence rate for hypertension was 45.83%, 52.27, 62.50%, 70.48%, and 62.79% from the first selenium quintile to the fifth quintile respectively. Comparing to the lowest quintile group, the hazard ratio were 1. for the second selenium quintile to the fifth quintile respectively. Conclusions:Our findings suggest that high selenium may play a harmful role in the development of hypertension. Future studies are needed to confirm our findings and to elucidate a plausible biological mechanism.

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Biomarkers of oxidant stress, insulin sensitivity and endothelial activation in rheumatoid arthritis: a cross-sectional study of their association with accelerated atherosclerosis

Cited by 33 publications

References 23 publications

Risk factors and early detection of atherosclerosis in rheumatoid arthritis

Risk factors and early detection of atherosclerosis in rheumatoid arthritis

Effects of Different Medical Treatments on Serum Copper, Selenium and Zinc Levels in Patients with Rheumatoid Arthritis

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

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