Biomarkers of Ovarian Reserve

Roudebush, William E.; Kivens, Wendy J.; Mattke, Jessica M.

doi:10.4137/bmi.s537

Cited by 49 publications

(37 citation statements)

References 62 publications

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“…AMH regulates folliculogenesis by inhibiting excessive follicular recruitment by follicle stimulating hormone (Roudebush & Mattke 2009). AMH can also serve as a marker for ovarian reserve and, thus, of reproductive potential in females (Roudebush et al 2008). In female manatees, no correlation was found between the levels of AMH and morphological parameters such as body length and weight.…”

Section: Discussionmentioning

confidence: 96%

“…By contrast, AMH is only produced by gonadal tissue, and serum levels directly reflect folliculogenesis/spermatogenesis activity; therefore, it is a more sensitive marker of reproductive potential than any other molecule, e.g. estradiol or testosterone (Roudebush et al 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Since its secretion is not dependent on gonadotropins or other hormones, and is expressed at a constant level independent of the cycle, AMH is attractive as a direct measurement of gonadal function or fertility potential (Roudebush et al 2008).…”

Section: Abstract: Manatee · Gonad · Anti-müllerian Hormone · Amh · mentioning

confidence: 99%

See 2 more Smart Citations

Secretion of anti-Müllerian hormone in the Florida manatee Trichechus manatus latirostris, with implications for assessing conservation status

Wilson¹,

Reynolds

Wetzel³

et al. 2011

Endang. Species. Res.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Secretion of anti-Müllerian hormone in the Florida manatee Trichechus manatus latirostris, with implications for assessing conservation status

Wilson¹,

Reynolds

Wetzel³

et al. 2011

Endang. Species. Res.

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“…Infertility is a prevalent disorder worldwide affecting 15-20 % of couples at the reproductive age [29]. Although infertility treatments have been improved through assisted reproductive technology (ART) over the past 30 years, the molecular reasons of infertility have not been fully identified [31].…”

Section: Introductionmentioning

confidence: 99%

Identification of the key regulating genes of diminished ovarian reserve (DOR) by network and gene ontology analysis

2016

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Diminished ovarian reserve (DOR) is one of the reasons for infertility that not only affects both older and young women. Ovarian reserve assessment can be used as a new prognostic tool for infertility treatment decision making. Here, up- and down-regulated gene expression profiles of granulosa cells were analysed to generate a putative interaction map of the involved genes. In addition, gene ontology (GO) analysis was used to get insight intol the biological processes and molecular functions of involved proteins in DOR. Eleven up-regulated genes and nine down-regulated genes were identified and assessed by constructing interaction networks based on their biological processes. PTGS2, CTGF, LHCGR, CITED, SOCS2, STAR and FSTL3 were the key nodes in the up-regulated networks, while the IGF2, AMH, GREM, and FOXC1 proteins were key in the down-regulated networks. MIRN101-1, MIRN153-1 and MIRN194-1 inhibited the expression of SOCS2, while CSH1 and BMP2 positively regulated IGF1 and IGF2. Ossification, ovarian follicle development, vasculogenesis, sequence-specific DNA binding transcription factor activity, and golgi apparatus are the major differential groups between up-regulated and down-regulated genes in DOR. Meta-analysis of publicly available transcriptomic data highlighted the high coexpression of CTGF, connective tissue growth factor, with the other key regulators of DOR. CTGF is involved in organ senescence and focal adhesion pathway according to GO analysis. These findings provide a comprehensive system biology based insight into the aetiology of DOR through network and gene ontology analyses.

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“…At birth, the ovary contains a finite number of oocytes available for folliculogenesis. This finite number of available oocytes is termed "the ovarian reserve" The determination of ovarian reserve is important in the assessment and treatment of infertility [17].…”

Section: Expression Of Slc39a10 Protein By Immunohistochemistry Analysismentioning

confidence: 99%

The Expression ofSolute carrier family membersGenes in Mouse Ovarian Developments

Lee-Gyun

Park

2017

Korean J Clin Lab Sci.

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analysis. SLC23A3 and SLC39A10 were highly expressed in the ovary. The SLC39A10 gene was expressed in the primordial follicle stage, but SLC23A3 was expressed in the growing follicle stage. Contrastingly, the expression of SLC23A3 was increased in granulosa cells at the growing follicle stage. The differential expressions of SLC23A3 and SLC39A10 between the primordial and primary follicles were additionally confirmed by using follicle isolations. The gene expression profile from the present study may provide insight for future studies on the mechanism(s) involved in primordial-primary follicular transition and suggestions to promote follicular development in ovarian dysfunction.

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Biomarkers of Ovarian Reserve

Cited by 49 publications

References 62 publications

Secretion of anti-Müllerian hormone in the Florida manatee Trichechus manatus latirostris, with implications for assessing conservation status

Secretion of anti-Müllerian hormone in the Florida manatee Trichechus manatus latirostris, with implications for assessing conservation status

Identification of the key regulating genes of diminished ovarian reserve (DOR) by network and gene ontology analysis

The Expression ofSolute carrier family membersGenes in Mouse Ovarian Developments

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