Biomarkers of necrotizing enterocolitis in the era of machine learning and omics

Leiva, Tyler; Lueschow, Shiloh R.; Burge, Kathryn; DeVette, Christa I.; McElroy, Steven J.; Chaaban, Hala

doi:10.1016/j.semperi.2022.151693

Cited by 2 publications

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia

Glaser,

Jensen,

Wright

2024

Neonatology

View full text Add to dashboard Cite

Background: The rates of major neonatal morbidities, such as bronchopulmonary dysplasia, necrotizing enterocolitis, preterm white matter disease, and retinopathy of prematurity, remain high among surviving preterm infants. Exposure to inflammatory stimuli and the subsequent host innate immune response contribute to the risk of developing these complications of prematurity. Notably, the burden of inflammation and associated neonatal morbidity is inversely related to gestational age – leaving primarily but not exclusively the tiniest babies at highest risk. Summary: Avoidance, prevention, and treatment of inflammation to reduce this burden remain a major goal for neonatologists worldwide. In this review, we discuss the link between the host response to inflammatory stimuli and the disease state. We argue that inflammatory exposures play a key role in the pathobiology of preterm birth and that preterm neonates hereafter are highly susceptible to immune stimulation not only from their surrounding environment but also from therapeutic interventions employed in clinical care. Using bronchopulmonary dysplasia as an example, we report clinical studies demonstrating the potential utility of targeting inflammation to prevent this neonatal morbidity. On the contrary, we highlight limitations in our current understanding of how inflammation contributes to disease prevention and treatment. Key Message: To be successful in preventing and treating inflammation-driven morbidity in neonatal intensive care, it may be necessary to better identify at-risk patients and pair therapeutic interventions to key pathways and mediators of inflammation-associated neonatal morbidity identified in pre-clinical and translational studies.

show abstract

Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia

Glaser,

Jensen,

Wright

2024

Neonatology

View full text Add to dashboard Cite

show abstract

Multi-omics Profiles are Applicable to Human Diseases and Drug Development

Espinosa-González,

Benítez-Flores,

Gómez-Verjan

et al. 2024

Biotechnology and Drug Development for Targeting Human Diseases

View full text Add to dashboard Cite

Traditional medicine has been a reliable source for the discovery of molecules with therapeutic activity against human diseases of clinical interest. In the past, knowledge of traditional medicine was mainly transmitted orally and in writing. Recently, the advent of “multiomics” tools (transcriptomics, metabolomics, epigenomics, proteomics, and lipidomics, among others) has increased and merged our knowledge, both traditional knowledge and that gained with these new multiomics technologies. In this way, the development of medicines with these 'multiomics technologies' has allowed pharmaceutical advances in the discovery of new drugs. In addition, 'multiomics' technologies have made it possible to uncover new biological activities of drugs that are currently used in clinical therapy. In the same way, 'multiomics' has allowed for the development of 'personalized medicine', that is, a particular and specific treatment and/or diagnosis of a patient with respect to a disease. Therefore, 'multiomics' technologies have facilitated the discovery of new clinical therapeutics for disease, as well as allowing for the diagnosis and/or treatment of diseases in an individual and personalized way.

show abstract

Biomarkers of necrotizing enterocolitis in the era of machine learning and omics

Cited by 2 publications

References 85 publications

Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia

Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia

Multi-omics Profiles are Applicable to Human Diseases and Drug Development

Contact Info

Product

Resources

About