Biomarkers of Infection and Risk of Coronary Heart Disease

Muhlestein, Joseph B.

doi:10.1007/978-1-59745-051-5_20

Cited by 1 publication

(1 citation statement)

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“…Several extracellular RNAs regulate the key processes linked to the pathogenesis of AMI. Many studies postulate that the expression of circulatory RNAs change over time and is affected by the duration and intensity of exposure to AMI risk factors, and may, therefore, be useful biomarkers in AMI diagnosis [5]. The ubiquitin Proteasome system (UPS) has been described as a way to remove the unwanted, or unneeded proteins [6].…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Molecular Network Expression in Acute Myocardial Infarction

Matboli

Shafei

Agwa

et al. 2019

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Background: In the current study, we aimed to analyze the hypothesis that human myocardial- specific extracellular RNAs expression could be used for acute myocardial injury(AMI) diagnosis. Methodology: We used bioinformatics’ analysis to identify RNAs linked to ubiquitin system and specific to AMI, named, (lncRNA-RP11-175K6.1), (LOC101927740), microRNA-106b-5p (miR-106b- 5p) and Anaphase, promoting complex 11 (ANapc11mRNA). We measured the serum expression of the chosen RNAs in 69 individuals with acute coronary syndromes, 31 individuals with angina pectoris without MI and non-cardiac chest pain and 31 healthy control individuals by real-time reversetranscription PCR. Results: Our study revealed a significant decrease in both lncRNA-RP11-175K6.1 and ANapc11mRNA expression of in the sera samples of AMI patients compared to that of the two control groups alongside with significant upregulation of miR-106b-5p. Conclusion: Of note, the investigated serum RNAs decrease the false discovery rate of AMI to 3.2%.

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Section: Introductionmentioning

confidence: 99%