Biomarkers of gastrointestinal functionality in dogs: A systematic review and meta-analysis

Félix, Ananda Portella; Souza, Camilla Mariane Menezes; Oliveira, Simone Gisele de

doi:10.1016/j.anifeedsci.2021.115183

Cited by 31 publications

(29 citation statements)

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“…Acetate is the most abundant SCFA and is an essential cofactor/ metabolite for the growth of many beneficial bacteria, while butyrate is considered one of the most important fermentative metabolites for gut health, being the main energy source for colonocytes and reducing gut inflammation (Chen & Vitetta, 2018;Zhong et al, 2019). The increase in the faecal concentration of butyrate was also reported in other studies evaluating the dietary supplementation of orange (Volpe et al, 2021) (Félix et al, 2022). It is important to mention that a less-diverse microbiota is more easily colonized by pathogens (Ellison et al, 2019;Ravi et al, 2019) and is associated with gastrointestinal disorders in dogs (Félix et al, 2022).…”

Section: Discussionmentioning

confidence: 64%

“…The changes observed in the fermentative metabolites in dogs fed CA are in accordance with the results of faecal microbiota. Dogs fed the CA diet presented greater intestinal bacterial diversity and richness (Chao1 and Shannon indexes) than the CO group, which are positive indicators of eubiosis (Félix et al, 2022). It is important to mention that a less‐diverse microbiota is more easily colonized by pathogens (Ellison et al, 2019; Ravi et al, 2019) and is associated with gastrointestinal disorders in dogs (Félix et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…(Clostridium Cluster IV), Blautia spp. (Clostridium Cluster XIVa) and Fusobacterium spp., are considered ‘sentinel’ bacteria because they are sensitive to changes in gut homoeostasis and are reduced in dogs with gastrointestinal diseases (AlShawaqfeh et al, 2017; Félix et al, 2022; Pilla & Suchodolski, 2020). Additionally, most of those genera are associated with the fermentation of dietary fibre and SCFA production (Pilla & Suchodolski, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Fine cassava fibre utilization as a dietary fibre source for dogs: Effects on kibble characteristics, diet digestibility and palatability, faecal metabolites and microbiota

Souza

Bastos

Kaelle

et al. 2023

Animal Physiology Nutrition

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The objective was to evaluate through three experiments the effects of a fine cassava fibre (CA: 106 μm) on kibble characteristics, coefficients of total tract apparent digestibility (CTTAD) of macronutrients, diet palatability and faecal metabolites and microbiota of dogs. Dietary treatments consisted of a control diet (CO), without an added fibre source and with 4.3% total dietary fibre (TDF), and a diet with 9.6% CA (106 μm), with 8.4% TDF. Experiment I evaluated the physical characteristics of the kibbles. The palatability test was evaluated in experiment II, which compared the diets CO versus CA. In experiment III, 12 adult dogs were randomly assigned to one of the two dietary treatments for 15 days, totalling six replicates/treatment, to assess the CTTAD of macronutrients; faecal characteristics, faecal metabolites and microbiota. The expansion index, kibble size and friability of diets with CA were higher than the CO (p < 0.05). Additionally, the CA diet presented higher palatability than the CO (p < 0.05) but did not affect CTTAD except for those of fibre (p > 0.05). Moreover, a greater faecal concentration of acetate, butyrate and total short-chain fatty acids (SCFA) and a lower faecal concentration of phenol, indole and isobutyrate were observed in dogs fed the CA diet (p < 0.05). Dogs fed with the CA diet presented a greater bacterial diversity and richness and a greater abundance of genera considered to be beneficial for gut health, such as Blautia, Faecalibacterium and Fusobacterium when compared to the CO group (p < 0.05). The inclusion of 9.6% of a fine CA improves the expansion of kibbles and diet palatability without affecting most of the CTTAD of nutrients. Besides, it improves the production of some SCFA and modulates the faecal microbiota of dogs.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fine cassava fibre utilization as a dietary fibre source for dogs: Effects on kibble characteristics, diet digestibility and palatability, faecal metabolites and microbiota

Souza

Bastos

Kaelle

et al. 2023

Animal Physiology Nutrition

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“…Besides the shifts observed in Bifidobacterium and Lactobacillus , dogs from the probiotic group also presented alterations in other bacterial genera, such as an increase in Turicibacter (important to serotonin metabolism in the gut) and Clostridium hiranonis (conversion of primary bile acids to secondary bile acids) and a reduction in E. coli , that is a potential pathogen [ 8 , 36 , 37 , 38 , 39 ]. The reduction in E. coli counts was also observed in the feces of dogs receiving dietary supplementation of live S. cerevisiae [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Yeast Saccharomyces cerevisiae as a Probiotic on Diet Digestibility, Fermentative Metabolites, and Composition and Functional Potential of the Fecal Microbiota of Dogs Submitted to an Abrupt Dietary Change

et al. 2023

Self Cite

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The aim was to evaluate the effects of yeast probiotic on diet digestibility, fermentative metabolites, and fecal microbiota of dogs submitted to dietary change. Sixteen dogs were divided into two groups of eight dogs each: control, without, and with probiotic, receiving 0.12 g/dog/day of live Saccharomyces cerevisiae yeast. The dogs were fed a lower protein and fiber diet for 21 days and then changed to a higher protein and fiber diet until day 49. Yeast supplementation did not statistically influence diet digestibility. The probiotic group had a lower fecal concentration of total biogenic amines (days 21 and 49), ammonia (day 23), and aromatic compounds and a higher fecal concentration of butyrate (p < 0.05). The probiotic group showed a lower dysbiosis index, a higher abundance (p < 0.05) of Bifidobacterium (days 35 and 49) and Turicibacter, and a lower abundance of Lactobacillus and E. coli (p < 0.05). Beta diversity demonstrated a clear differentiation in the gut microbiota between the control and probiotic groups on day 49. The control group showed upregulation in genes related to virulence factors, antibiotic resistance, and osmotic stress. The results indicated that the live yeast evaluated can have beneficial effects on intestinal functionality of dogs.

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“…The authors also showed that fecal calprotectin could be used as a possible marker for assessing the severity of gastrointestinal inflammation in dogs with CIE [61]. Additionally, a recent meta-analysis concluded that fecal calprotectin concentration is one of the most promising biomarkers of gastrointestinal functionality in dogs [62].…”

Section: Neutrophilsmentioning

confidence: 98%

Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy—A Search for Potential Biomarkers

Siel

Beltrán

Martínez-Camacaro

et al. 2022

Animals

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Canine chronic inflammatory enteropathy (CIE) is one of the most common chronic gastrointestinal diseases affecting dogs worldwide. Genetic and environmental factors, as well as intestinal microbiota and dysregulated host immune responses, participate in this multifactorial disease. Despite advances explaining the immunological and molecular mechanisms involved in CIE development, the exact pathogenesis is still unknown. This review compiles the latest reports and advances that describe the main molecular and cellular mechanisms of both the innate and adaptive immune responses involved in canine CIE pathogenesis. Future studies should focus research on the characterization of the immunopathogenesis of canine CIE in order to advance the establishment of biomarkers and molecular targets of diagnostic, prognostic, or therapeutic utility.

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Biomarkers of gastrointestinal functionality in dogs: A systematic review and meta-analysis

Cited by 31 publications

References 50 publications

Fine cassava fibre utilization as a dietary fibre source for dogs: Effects on kibble characteristics, diet digestibility and palatability, faecal metabolites and microbiota

Fine cassava fibre utilization as a dietary fibre source for dogs: Effects on kibble characteristics, diet digestibility and palatability, faecal metabolites and microbiota

Effect of Yeast Saccharomyces cerevisiae as a Probiotic on Diet Digestibility, Fermentative Metabolites, and Composition and Functional Potential of the Fecal Microbiota of Dogs Submitted to an Abrupt Dietary Change

Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy—A Search for Potential Biomarkers

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