Biomarkers of exposure to environmental contaminants in French pregnant women from the Elfe cohort in 2011

Dereumeaux, Clémentine; Saoudi, Abdesattar; Pêcheux, Marie-Germaine; Berat, Bénédicte; Crouy-Chanel, Perrine de; Zaros, Cécile; Brunel, Serge; Delamaire, Corinne; Tertre, Alain Le; Lefranc, Agnès; Vandentorren, Stéphanie; Guldner, Laurence

doi:10.1016/j.envint.2016.10.013

Cited by 96 publications

(32 citation statements)

References 62 publications

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“…This approach needs to be validated by the determination of biomarkers. For DiNP and DINCH, which metabolise rapidly in the organism and are largely excreted in the urine, oxidized metabolites measured in urine are reliable biomarkers [57–59]. In contrast, for TOTM, which accumulates in the tissues and is eliminated more slowly, mainly in the stools [60], measuring metabolites in urine is not suitable.…”

Section: Discussionmentioning

confidence: 99%

Exposure of hospitalised pregnant women to plasticizers contained in medical devices

et al. 2017

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BackgroundMedical devices (MDs) in polyvinyl chloride (PVC) are not a well-known source of exposure to plasticizers, in particular during pregnancy. Because of its toxicity, the di-(2-ethylhexyl) phthalate (DEHP) has been replaced by other plasticizers such as di (isononyl)-cyclohexane-1,2-dicarboxilic acid (DINCH), tri-octyltrimellitate (TOTM) and di-(isononyl) phthalate (DiNP). Our study aimed to quantify the plasticizers (DEHP and alternative plasticizers) contained in PVC medical devices used for hospitalised pregnant women and to describe which these MDs had been used (type, number, duration of exposure).MethodsThe plasticizers contained in the MDs used for daily care in the Obstetrics Department of a French University Hospital were extracted from PVC (after contact with a chloroform solution), identified and quantified by gas-chromatography-mass-spectrometry analysis. A total of 168 pregnant women hospitalised in the Obstetrics Department with at least one catheter were included in the observational study. The median number of MDs containing plasticizers used and the daily duration of exposure to the MDs were compared in three groups of pregnant women: “Pathology group” (women hospitalised for an obstetric disorder who did not give birth during this hospitalisation; n = 52), “Pathology and delivery group” (hospitalised for an obstetric disorder and who gave birth during this stay; n = 23) and “Delivery group” (admitted for planned or spontaneous delivery without obstetric disorder; n = 93).ResultsDiNP, TOTM and DINCH were the predominant plasticizers contained in the MDs at an amount of 29 to 36 g per 100 g of PVC. Women in the “Pathology group” (preterm labour or other pathology) were exposed to a median number of two MDs containing TOTM and one MD containing DiNP, fewer than those in the “Pathology and delivery group” (p < 0.05). Women in the “Pathology group” had a median exposure of 3.4 h/day to MDs containing DiNP and 8.2 h/day to MDs containing TOTM, longer than those in the “Delivery group” (p < 0.01).ConclusionsOur study shows that the medical management of pregnant women in a hospital setting entails exposure to MDs containing alternative plasticizers (DiNP, TOTM and DINCH).Electronic supplementary materialThe online version of this article (doi:10.1186/s12905-017-0398-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Exposure of hospitalised pregnant women to plasticizers contained in medical devices

et al. 2017

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“…Some of the already identified and well-established chemicals with endocrine-disrupting properties include organochlorine pesticides, polybrominated diphenyl ethers, polychlorinated biphenyls, toxic metals, as well as phthalates and bisphenol A [1,[20][21][22][23]. The results from a recent nation-wide survey of the levels of environmental contaminants among pregnant women in France showed that these chemicals are quantifiable in virtually all individuals [24].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.

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“…Indoor environment is a mixture of physical, chemical, and biological pollutants that originate from outdoor air, building and decorative materials, combustion appliances, and human activity [ 9 ]. Exposure to indoor environmental pollutants in the general population is ubiquitous, multiple, and chronic [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. The routes of exposure and penetration into the body are ingestion, inhalation, dermal, mucosal, and transplacental.…”

Section: Introductionmentioning

confidence: 99%

Perceptions, Knowledge, and Practices Concerning Indoor Environmental Pollution of Parents or Future Parents

Daniel

Michot

Esvan

et al. 2020

IJERPH

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Indoor pollutants can have short- and long-term health effects, especially if exposure occurs during prenatal life or early childhood. This study describe the perceptions, knowledge, and practices of adults concerning indoor environmental pollution. Adults of 18 to 45 years of age were recruited in the department of Ille-et-Vilaine (Brittany-France) in 2019 through a stratified random draw in the waiting rooms of general practitioners (GPs) (n = 554) who completed a self-questionnaire. The 71% who had already heard of this type of pollution were older (p = 0.001), predominantly women (p = 0.007), not expecting a baby (p = 0.005), and had a higher knowledge score (p < 0.001). The average knowledge score was 6.6 ± 6.6 out of 11, which was higher for participants living in a couple and with a higher level of education (p < 0.001). Some practices were well implemented (>80% of participants) (aeration during renovation) whereas others were insufficiently practiced (<60% of participants) (paying attention to the composition of cosmetic products). Factors associated differed depending on the frequency of integration: living in a couple and having a child for well implemented practices and educational level, knowledge level, and perception for those under implemented. Knowledge must be improved to modify perceptions and certain practices, making sure not to increase social inequalities in health.

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Biomarkers of exposure to environmental contaminants in French pregnant women from the Elfe cohort in 2011

Cited by 96 publications

References 62 publications

Exposure of hospitalised pregnant women to plasticizers contained in medical devices

Exposure of hospitalised pregnant women to plasticizers contained in medical devices

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Perceptions, Knowledge, and Practices Concerning Indoor Environmental Pollution of Parents or Future Parents

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