Biomarkers of environmental manganese exposure

Shilnikova, Natalia S.; Karyakina, Nataliya A.; Farhat, Nawal; Ramoju, Siva; Cline, Brandon; Momoli, Franco; Mattison, Donald R.; Jensen, N; Terrell, R; Krewski, Daniel

doi:10.1080/10408444.2022.2095979

Cited by 13 publications

(4 citation statements)

References 116 publications

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“…Generally, toenails are considered less susceptible to external contamination than hair because, for a given sample weight, toenails have a smaller surface-to-volume ratio. 149 , 150 However, there is also a lack of standardized cleaning methods for toenails. 151 …”

Section: Discussionmentioning

confidence: 99%

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

McBride,

Bhattacharya,

Sucharew

et al. 2024

Environ Health Perspect

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Background: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance. Objectives: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort. Methods: Participants were recruited into CARES when they were 7–9 y old, and reenrolled at 13–18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height–weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine. Results: CARES participants who completed the adolescent postural balance assessment ( ) were 98% White and 54% female and had a mean age of 16 y (range: 13–18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males. Discussion: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. https://doi.org/10.1289/EHP13381

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Section: Discussionmentioning

confidence: 99%

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

McBride,

Bhattacharya,

Sucharew

et al. 2024

Environ Health Perspect

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“…Several authors of the present study have recently published detailed critical reviews of occupational ( 20 ) and environmental ( 21 ) biomarkers of Mn exposure. Although certain serum biomarkers of Mn exposure are promising, workshop participants generally agreed that no ideal biomarkers are currently available and that different biomarkers represent different windows of exposure.…”

Section: Summary Of Workhop Discussionmentioning

confidence: 99%

Diagnosis of manganism and manganese neurotoxicity: A workshop report

Mattison,

Momoli,

Alyanak

et al. 2024

Med Int

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With declining exposures to manganese (Mn) in occupational settings, there is a need for more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn neurotoxicity. To address this issue, a workshop was held on November 12-13, 2020, with international experts on Mn toxicity. The workshop discussions focused on the history of the diagnostic criteria for manganism, including those developed by the Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail (IRSST) in Quebec in 2005 and criteria developed by the Chinese government in 2002 and updated in 2006; the utility of biomarkers of exposure; recent developments in magnetic resonance imaging (MRI) for assessing Mn accumulation in the brain and diagnosing manganism; and potential future applications of metabolomics. The suggestions of the participants for updating manganism diagnostic criteria included the consideration of: i) A history of previous occupational and environmental exposure to Mn; ii) relevant clinical symptoms such as dystonia; iii) MRI imaging to document Mn accumulation in the neural tissues, including the basal ganglia; and iv) criteria for the differential diagnosis of manganism and other neurological conditions. Important research gaps include the characterization of Mn exposure and other co-exposures, exploration of the roles of different brain regions with MRI, understanding the complexity of metal ion transporters involved in Mn homeostasis, and a need for information on other neurotransmitter systems and brain regions underlying the pathophysiology of manganism.

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“…Therefore, it is essential to consider that the reference values for these Mn biomarkers are also not related to the threshold compatible with the beneficial or deleterious effects of Mn. For the time being, there is little data on these matrices used as biomarkers either in the general population or in pregnant women [ 2 , 56 , 57 ]. Studies in populations with low levels are therefore essential to contribute to the correct definition of these reference values concerning possible effects; our cohort study has the final objective of estimating the impact of these exposures on children’s neurodevelopment at 12 months.…”

Section: Discussionmentioning

confidence: 99%

“…Three factors associated with higher levels of Mn mainly stood out in the MLR: SES, waste burning, and passive exposure to cigarette smoke. However, most publications were carried out in populations with high exposure and mainly considered correlations or univariate analyzes [ 56 ], which makes comparisons difficult. Despite using hair and nails as matrices to estimate exposure to Mn, Viana et al [ 4 ], found no correlation between Mn exposure and cigarette smoking or waste burning.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Exposure to Potentially Toxic Metals in Pregnant Women of the DSAN-12M Cohort in the Recôncavo Baiano, Brazil

Bah

Martinez

Santos

et al. 2023

IJERPH

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Exposure to potentially toxic metals (PTM) threatens maternal and child health. We investigated the determinants of exposure to lead (Pb), cadmium (Cd), arsenic (As), and manganese (Mn) in 163 pregnant women from the Recôncavo Baiano, Brazil, enrolled in the DSAN-12M cohort. We measured these metals in biological samples (blood, toenails, and hair) and the Pb dust loading rates (RtPb) at their homes by graphite furnace atomic absorption spectrophotometry (GFAAS). Questionnaires were applied to collect sociodemographic and general habits data. Only 2.91% (n = 4) of the pregnant women had As levels above the detection limit. Few participants had levels above the recommended reference values for blood Pb (5.1; 95% CI: 2.1–10.1%), and Mn in hair or toenails (4.3; 95% CI: 2.3–10.1%). On the other hand, 61.1 (95% CI: 52.4–69.3%) had elevated blood Cd levels. After binary logistic regression, low socioeconomic status, domestic waste burning, being a passive smoker, multiparity, and renovating the house significantly increased the chances of having high levels of Mn, Pb, and Cd. We detected a worrying situation related to exposure to Cd, showing the urgency of implementing human biomonitoring in the general population, especially in situations of social vulnerability.

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Biomarkers of environmental manganese exposure

Cited by 13 publications

References 116 publications

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants

Diagnosis of manganism and manganese neurotoxicity: A workshop report

Determinants of Exposure to Potentially Toxic Metals in Pregnant Women of the DSAN-12M Cohort in the Recôncavo Baiano, Brazil

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