Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis

Andrianto, Andrianto; Al-Farabi, Makhyan Jibril; Nugraha, Ricardo Adrian; Marsudi, Bagas Adhimurda; Azmi, Yusuf

doi:10.1101/2021.01.24.21250389

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Patients who developed severe forms of the disease present with thrombotic phenomena ( Leentjens et al, 2021 ) and systemic inflammation ( Del Valle et al, 2020 ), suggesting the participation of the endothelium in the disease pathogenesis ( Nicosia et al, 2021 ). Moreover, increased endothelial injury markers have been found in COVID-19 patients and are correlated to the disease severity ( Andrianto et al, 2021 ).…”

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confidence: 99%

Endothelial injury in COVID-19 and septic patients

Hokama

Veiga

Menezes

et al. 2022

Microvascular Research

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Systemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included patients diagnosed with sepsis (SEPSIS group, n = 21), mild COVID-19 (MILD group, n = 31), and severe COVID-19 (SEVERE group, n = 24). Clinical and routine laboratory data were obtained, circulating cytokines (INF-γ, TNF-α, and IL-10) and endothelial injury markers (E-Selectin, Tissue Factor (TF) and von Willebrand factor (vWF)) were measured. Compared to the SEPSIS group, patients with severe COVID-19 present similar clinical and laboratory data, except for lower circulating IL-10 and E-Selectin levels. Compared to the MILD group, patients in the SEVERE group showed higher levels of TNF-α, IL-10, and TF. There was no clear relationship between cytokines and endothelial injury markers among the three studied groups; however, in SEVERE COVID-19 patients, there is a positive relationship between INF-γ with TF and a negative relationship between IL-10 and vWF. In conclusion, COVID-19 and septic patients have a similar pattern of cytokines and endothelial dysfunction markers. These findings highlight the importance of endothelium dysfunction in COVID-19 and suggest that endothelium should be better evaluated as a therapeutic target for the disease.

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Section: Introductionmentioning

confidence: 99%

Endothelial injury in COVID-19 and septic patients

Hokama

Veiga

Menezes

et al. 2022

Microvascular Research

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“…Raised cardiac biomarkers involving CK, CK-MB, LDH, Mb, cTnI, α-HBDH, AST, and NT-proBNP were observed especially in severe illness and were associated with higher mortality. The proposed biomarkers play an essential role in early suspicion, diagnosis, monitoring, and recognition of acute complications, but what about on the long-term effects of COVID-19?In July 2021, Andrianto et al[57] conducted a literature search for observational studies that analysed the relationship between ED biomarkers and clinical outcomes in COVID-19 patients. In a meta-analysis that included 1187 patients from 17 studies, VWF antigen, PAI-1, t-PA, sTM were predictors of worse outcome in COVID-19 patients.…”

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confidence: 99%

Long-term Cardio-vascular Risk Assessment in Chronic Kidney Disease and Kidney Transplanted Patients Following SARS-COV-2 Disease: Protocol for Multi-center Observational Match Controlled Trial

Țăpoi

Apetrii

Dodi

et al. 2022

Preprint

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BackgroundThe coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced a pandemic since March 2020 by affecting more than 243 million people with more than 5 million deaths globally. SARS-CoV-2 infection is produced by binding to angiotensin-converting enzyme, which among other sites is highly expressed in the endothelial cells of the blood vessels, pericytes and the heart, as well as in renal podocytes and proximal tubular epithelial cells. SARS-CoV-2 and cardiovascular disease (CVD) are interconnected by risk factors association with an increased incidence of the disease and by determining de novo cardiac complications. At the same time, COVID-19 disease can lead to acute kidney injury directly, or due to sepsis, multi-organ failure and shock. Therefore, the pre-existence of both CVD and chronic kidney disease (CKD) is linked with a higher risk of severe disease and worse prognosis. MethodsThe main aim of this study is to assess the CV risk in a CKD (stage 3 to 5), dialysis and kidney transplanted population, following SARS-CoV-2 infection, with focus on the endothelial dysfunction as compared to a control group of matched patients. By using clinical evaluation, flow-mediated dilatation, carotid-femoral pulse wave velocity, intima-media thickness, echocardiographic parameters, lung ultrasound, bioimpedance spectroscopy and a series of novel biomarkers, the investigators will determine the long-term impact of this disease on CV and renal outcomes.DiscussionThis study will address the challenges and implications in long-term CV sequeale of COVID-19 and focus on a better understanding of the underlying mechanisms and possible therapeutic options.Trial RegistrationClinicalTrials.gov NCT05125913. Registered November 18, 2021.

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Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis

Cited by 2 publications

References 52 publications

Endothelial injury in COVID-19 and septic patients

Endothelial injury in COVID-19 and septic patients

Long-term Cardio-vascular Risk Assessment in Chronic Kidney Disease and Kidney Transplanted Patients Following SARS-COV-2 Disease: Protocol for Multi-center Observational Match Controlled Trial

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