“…5,6 "A dysregulated host response to infection" 7 is the consensus definition of sepsis, 7 but the pathophysiological basis of this immune dysregulation remains incompletely defined. Hallmark hostresponses characterising sepsis 8,9 are also found in lifethreatening HIVassociated tuberculosis disease, including con current inflammatory and immuno suppressive signalling, 4,10 coagulation and endothelial activation, 11,12 innate cell activation and dysfunction, 4,13 and…”