Biomarkers of endometriosis

Pant, Anuja; Moar, Kareena; K. Arora, Taruna; Maurya, Pawan Kumar

doi:10.1016/j.cca.2023.117563

Cited by 9 publications

(3 citation statements)

References 119 publications

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“…Biomarkers serve as vital components in the diagnosis of endometriosis, providing valuable insights into the presence and severity of the disease. These biomolecules encompass diverse substances, including proteins, genes, lipids, RNA, DNA, enzymes, and hormones, reflecting endometriosis's physiological state or condition [ 10 ]. While certain individual biomarkers, like CA-125, have been extensively investigated, their diagnostic accuracy may be limited when utilized in isolation.…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of the Diagnostic Landscape of Endometriosis: Assessing Tools, Uncovering Strengths, and Acknowledging Limitations

Dantkale,

Agrawal

2024

Cureus

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Endometriosis is a prevalent yet often underdiagnosed condition characterized by the presence of endometrial-like tissue outside the uterus, leading to significant morbidity and impaired quality of life. A timely and accurate diagnosis of endometriosis is essential for effective management and improved patient outcomes. This review provides a comprehensive overview of the current diagnostic landscape of endometriosis, including clinical evaluation, imaging modalities, biomarkers, and laparoscopy. The strengths and limitations of each diagnostic approach are critically evaluated, alongside challenges such as delayed diagnosis and misinterpretation of findings. The review emphasizes the importance of multidisciplinary collaboration, standardized diagnostic protocols, and ongoing research to enhance diagnostic accuracy and facilitate early intervention. By addressing these challenges and leveraging emerging technologies, healthcare professionals can improve the diagnosis and management of endometriosis, ultimately enhancing the well-being of affected individuals.

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Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of the Diagnostic Landscape of Endometriosis: Assessing Tools, Uncovering Strengths, and Acknowledging Limitations

Dantkale,

Agrawal

2024

Cureus

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“…As a result, individuals with this condition frequently experience debilitating symptoms, most notably chronic pelvic pain. This pain can be exacerbated during menstrual periods and can significantly impair daily activities and quality of life [3,[8][9][10][11]. The treatment strategies for endometriosis are equally varied, encompassing pain management, hormonal therapies, and surgical options aimed at removing endometrial implants.…”

Section: Introductionmentioning

confidence: 99%

“…Understanding this interaction between endometriosis and stress is crucial for providing more comprehensive insights into the impacts of the condition on the mental health of affected women. Pain is a central manifestation of endometriosis, and its intensity can vary considerably among affected women [6,[9][10][11]16]. Additionally, endometriosis is associated with a chronic inflammatory state, suggesting a possible link between pain and inflammatory processes [6,16].…”

Section: Introductionmentioning

confidence: 99%

What Is Behind? Impact of Pelvic Pain on Perceived Stress and Inflammatory Markers in Women with Deep Endometriosis

Osaki,

Oliveira

2024

JCM

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Introduction/Objectives: Endometriosis affects 10% of women worldwide. It is noteworthy that this condition is often accompanied by pelvic pain and stress. Endometriosis is a debilitating gynecological condition where tissue similar to the uterine lining grows outside the uterus, often causing significant pain and reproductive issues. We aimed to study the relationship between the intensity of pelvic pain, and stress and inflammatory markers in women with deep endometriosis. Methods: This cross-sectional study analyzed women diagnosed with deep endometriosis through imaging, surgery, and/or biopsy. We assessed pain using the Numerical Rating Scale (NRS). Stress was assessed with the Perceived Stress Scale (PSS-10) questionnaire and the serum cortisol levels. Additionally, we analyzed inflammatory markers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Results: Fifty-two women, with an average age of 37.8 ± 6.9 years, participated in this study. Forty-four percent of these participants demonstrated high levels of stress, as indicated by scores above 26 on the PSS-10. Those categorized with “high stress” on the PSS-10 questionnaire exhibited significantly higher pain levels compared to those with “low stress” (p < 0.05). Furthermore, patients experiencing more-severe pelvic pain (pain score > 7) had notably higher serum cortisol levels. Women with intense pelvic pain (scores above 7 on the NRS) had significantly elevated serum cortisol levels (Cohen’s d = 0.72; p = 0.018). Conclusions: A positive association was found between stress levels and the intensity of pelvic pain in women with deep endometriosis, suggesting an interconnection between emotional aspects and biological responses.

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Mining phase separation-related diagnostic biomarkers for endometriosis through WGCNA and multiple machine learning techniques: a retrospective and nomogram study

Liang,

Yang,

Mai

et al. 2024

J Assist Reprod Genet

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Biomarkers of endometriosis

Cited by 9 publications

References 119 publications

A Comprehensive Review of the Diagnostic Landscape of Endometriosis: Assessing Tools, Uncovering Strengths, and Acknowledging Limitations

A Comprehensive Review of the Diagnostic Landscape of Endometriosis: Assessing Tools, Uncovering Strengths, and Acknowledging Limitations

What Is Behind? Impact of Pelvic Pain on Perceived Stress and Inflammatory Markers in Women with Deep Endometriosis

Mining phase separation-related diagnostic biomarkers for endometriosis through WGCNA and multiple machine learning techniques: a retrospective and nomogram study

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