Biomarkers of Endometrial Receptivity—A Review

Cavagna, M.; Mantese, João Carlos

doi:10.1016/s0143-4004(03)00184-x

Cited by 113 publications

(88 citation statements)

References 115 publications

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“…Progesterone dependent, pinopodes are present 20-21 days into the luteal cycle. [Cavagna & Mantese, 2003] Their function has not fully been established, but pinopodes are thought to play a role in protecting the blastocyst from being swept by the cilia on the endometrial wallpromoting withdrawal of uterine fluid and facilitating molecular adhesion of the pinopodes with the blastocyst. The life span of fully developed pinopodes lasts no more than 48 hours suggesting a transient cell state.…”

Section: Pinopodesmentioning

confidence: 99%

“…The life span of fully developed pinopodes lasts no more than 48 hours suggesting a transient cell state. Following ovarian stimulation with clomiphene citrate and human chorionic gonadotropin (hCG), pinopodes formed a little earlier, on days 17 or 18 than in the natural state.. [Cavagna & Mantese, 2003] It is thus possible that ovarian stimulation and early pinopode formation may have a role in shifting the window of receptivity resulting in asynchrony between the endometrium and blastocyst thereby negatively influencing implantation rates with IVF.…”

Section: Pinopodesmentioning

confidence: 99%

“…It has been shown that HB-EGF expression is low during the proliferative endometrial phase, attaining its highest measure immediately prior to the implantation window, suggesting that it may have a role during the blastocyst implantation process. [Cavagna & Mantese, 2003;Lessey et al, 2002] It has been suggested that HB-EGF promotes implantation and trophoblast invasion through paracrine/autocrine signaling as cells penetrate the stroma. HB-EGF has also been shown to inhibit apoptosis and induces an invasive trophoblast phenotype.…”

Section: Heparin Binding-epidermal Growth Factormentioning

confidence: 99%

“…The co-existence of HB-EGF and pinopodes has been investigated with electron microscopy and immunochemistry, and shows that the expres s i o n o f H B -E G F i s h i g h e s t w h e n f u l l y developed pinopodes are present, supporting the role of HB-EGF in the implantation process. [Cavagna & Mantese, 2003, Stavreus et al, 2001]…”

Section: Heparin Binding-epidermal Growth Factormentioning

confidence: 99%

“…According to Zhu, biomarkers are those that are present in the endometrium during the implantation phase, close to the implantation site, and disappear thereafter. [Cavagna & Mantese, 2003] This chapter will discuss biomarkers and their role in the attachment and invasion process during the implantation phase.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Biomarkers Related to Endometrial Receptivity and Implantation

Trolice¹,

Amyradakis²

2012

Advances in Embryo Transfer

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Section: Pinopodesmentioning

confidence: 99%

Section: Pinopodesmentioning

confidence: 99%

Section: Heparin Binding-epidermal Growth Factormentioning

confidence: 99%

Section: Heparin Binding-epidermal Growth Factormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biomarkers Related to Endometrial Receptivity and Implantation

Trolice¹,

Amyradakis²

2012

Advances in Embryo Transfer

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The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo

Wang

Liu

et al. 2018

FEBS Letters

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The receptive uterine endometrium specifically expresses certain glycosyltransferases, and the corresponding oligosaccharides play important roles in accepting the embryo. The sialyltransferase β-galactoside-α2,3-sialyltransferase III (ST3Gal3) is the key enzyme responsible for sialyl Lewis X (sLeX) oligosaccharide biosynthesis, but the expression and function of ST3Gal3 in the receptive endometrium is still elusive. Here, we found that human endometrial tissues at secretory phase expressed a 4-fold higher ST3Gal3 level relative to the tissues at proliferative phase. Meanwhile, downregulation of ST3Gal3 or sLeX epitope blockage significantly impaired the receptive ability of human endometrial RL95-2 cells to trophoblastic cells in vitro and inhibited implantation in pregnant mice. This study suggests that ST3Gal3 facilitates endometrial receptivity through increasing sLeX oligosaccharide, which gives a better understanding of the glycobiology of implantation.

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Reproductive ecology and the endometrium: Physiology, variation, and new directions

Clancy

2009

American J Phys Anthropol

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Endometrial function is often overlooked in the study of fertility in reproductive ecology, but it is crucial to implantation and the support of a successful pregnancy. Human female reproductive physiology can handle substantial energy demands that include the production of fecund cycles, ovulation, fertilization, placentation, a 9-month gestation, and often several years of lactation. The particular morphology of the human endometrium as well as our relative copiousness of menstruation and large neonatal size suggests that endometrial function has more resources allocated to it than many other primates. The human endometrium has a particularly invasive kind of hemochorial placentation and trophoblast that maximizes surface area and maternalfetal contact, yet these processes are actually less efficient than the placentation of some of our primate relatives. The human endometrium and its associated processes appear to prioritize maximizing the transmission of oxygen and glucose to the fetus over efficiency and protection of maternal resources. Ovarian function controls many aspects of endometrial function and thus variation in the endometrium is often a reflection of ecological factors that impact the ovaries. However, preliminary evidence and literature from populations of different reproductive states, ages and pathologies also suggests that ecological stress plays a role in endometrial variation, different from or even independent of ovarian function. Immune stress and psychosocial stress appear to play some role in the endometrium's ability to carry a fetus through the mechanism of inflammation. Thus, within reproductive ecology we should move towards a model of women's fecundity and fertility that includes many components of ecological stress and their effects not only on the ovaries, but on processes related to endometrial function. Greater attention on the endometrium may aid in unraveling several issues in hominoid and specifically human evolutionary biology: a low implantation rate, high rates of early pregnancy loss, prenatal investment in singletons but postnatal support of several dependent offspring at once, and higher rate of reproductive and pregnancy-related pathology compared to other primates, ranging from endometriosis to preeclampsia. The study of the endometrium may also complicate some of these issues, as it raises the question of why humans have a maximally invasive placentation method and yet slow fetal growth rates. In this review, I will describe endometrial physiology, methods of measurement, variation, and some of the ecological variables that likely produce variation and pregnancy losses to demonstrate the necessity of further study. I propose several basic avenues of study that leave room for testable hypotheses in the field of reproductive ecology. And finally, I describe the potential of this work not just in reproductive ecology, but in the resolution of broader women's health issues. Yrbk Phys Anthropol 52: 137-154, 2009.

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Biomarkers of Endometrial Receptivity—A Review

Cited by 113 publications

References 115 publications

Biomarkers Related to Endometrial Receptivity and Implantation

Biomarkers Related to Endometrial Receptivity and Implantation

The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo

Reproductive ecology and the endometrium: Physiology, variation, and new directions

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