Biomarkers of Blast-Induced Neurotrauma: Profiling Molecular and Cellular Mechanisms of Blast Brain Injury

Svetlov, Stanislav I.; Larner, Stephen F.; Kirk, Daniel; Atkinson, J. Hampton; Hayes, Ronald L.; Wang, Kevin

doi:10.1089/neu.2008.0609

Cited by 89 publications

(71 citation statements)

References 84 publications

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“…A careful analysis of clinical TBI cases has revealed that damage to specific areas in the brain such as the hippocampus and amygdala have a role in the development of PTSD (Koenigs et al, 2008). A further analysis of gene expression or protein changes in such regions could possibly provide insights for development of useful biomarkers that could facilitate diagnosis after different overlapping TBI initiating events (Svetlov et al, 2009). Our primary blast model seems to represent a mild TBI model, whereas the focal and rotational injury models represent lesions that could be the result of secondary and tertiary blast injury and also fit the conventional definition of a mTBI model.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of blast induced brain injuries, experimental studies in rats

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Mechanisms of blast induced brain injuries, experimental studies in rats

et al. 2011

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“…More recently, this definition has been widened to include other forms of data that provide consistent markers of diagnosis, pathophysiology, disease severity, prognosis, appropriate therapy or evidence of response to therapy. In the context of TBI, much of the literature has focused on biomarkers in blood or CSF, using either conventional [60,61] or novel [62,63] tools. Two approaches have been adopted to detect biomarkers.…”

Section: Imaging and Molecular Biomarkersmentioning

confidence: 99%

Traumatic brain injury

Risdall

Menon

2011

Phil. Trans. R. Soc. B

148

102

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There is an increasing incidence of military traumatic brain injury (TBI), and similar injuries are seen in civilians in war zones or terrorist incidents. Indeed, blast-induced mild TBI has been referred to as the signature injury of the conflicts in Iraq and Afghanistan. Assessment involves schemes that are common in civilcian practice but, in common with civilian TBI, takes little account of information available from modern imaging (particularly diffusion tensor magnetic resonance imaging) and emerging biomarkers. The efficient logistics of clinical care delivery in the field may have a role in optimizing outcome. Clinical care has much in common with civilian TBI, but intracranial pressure monitoring is not always available, and protocols need to be modified to take account of this. In addition, severe early oedema has led to increasing use of decompressive craniectomy, and blast TBI may be associated with a higher incidence of vasospasm and pseudoaneurysm formation. Visual and/or auditory deficits are common, and there is a significant risk of post-traumatic epilepsy. TBI is rarely an isolated finding in this setting, and persistent post-concussive symptoms are commonly associated with post-traumatic stress disorder and chronic pain, a constellation of findings that has been called the polytrauma clinical triad.

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“…For this purpose, the areas of proteomic/genomic methods have been the key instruments in the discovery of novel brain injury biomarker candidates [3][4][5][6]. As discussed below, several brain injury biomarkers have the potential to revolutionize medical practice and biomedical research in the area of TBI [7].…”

Section: Abstract Biomarkers Brain Injury Cell Death Proteolysismentioning

confidence: 99%

Protein Biomarkers for Traumatic and Ischemic Brain Injury: From Bench to Bedside

Zhang

Mondello

Kobeissy

et al. 2011

Transl. Stroke Res.

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Stroke is the second leading cause of death worldwide and the third leading cause of death in the USA. A clinically useful biomarker for the diagnosis of stroke does not currently exist. Biomarkers could improve stroke care by allowing early diagnosis by non-expert clinical providers, serial monitoring of patients, and rapid assessment of severity of brain injury. With the introduction of highly advanced multidimensional separation techniques coupled with high throughput genomics/proteomics platforms, several components of the pathophysiological and biochemical pathways have been elucidated in the areas of brain trauma. A major outcome of these approaches is the discovery of biomarkers that would have important applications in diagnosis, prognosis, and even development of experimental neuroprotective drugs that have been used in different paradigms of brain injury. In this paper, we reviewed the recent advances of current and novel brain injury protein biomarkers and their utilities in different models of brain injury with an emphasis on stroke, an area that has been understudied. This will include the utility of neuroproteomics/neurosystems biology analysis as a novel discipline leading to the identification of novel biomarkers that can reach the pipeline of bench side. Additionally, an outline of biomarker-based management of traumatic brain injury and stroke patient assessments of therapeutic interventions has been included. Finally, comparison of current biomarker occurrence between preclinical models and biomarker data from human clinical studies for stroke has been summarized.

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Biomarkers of Blast-Induced Neurotrauma: Profiling Molecular and Cellular Mechanisms of Blast Brain Injury

Cited by 89 publications

References 84 publications

Mechanisms of blast induced brain injuries, experimental studies in rats

Mechanisms of blast induced brain injuries, experimental studies in rats

Traumatic brain injury

Protein Biomarkers for Traumatic and Ischemic Brain Injury: From Bench to Bedside

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