Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients

Nacaroğlu, Hikmet Tekin; Gayret, Özlem Bostan; Erol, Meltem; Büke, Övgü; Zengi, Oğuzhan; Taşdemir, Müge; Taşdemir, Zekeriya; Yiğit, Özgül

doi:10.1016/j.aller.2017.01.013

Cited by 11 publications

(12 citation statements)

References 30 publications

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“…16 In a study conducted by Akelma et al, 24 serum osteopontin levels were found to be higher in children with asthma than in controls and higher in those with allergic rhinitis than those without. In another study conducted by Nacaroglu et al, 25 no difference was found between children with asthma and the control group in terms of osteopontin levels. According to a recently published meta-analysis including these two studies, osteopontin expression in participants with asthma was found to be higher than that in the healthy controls.…”

Section: Discussionmentioning

confidence: 81%

Can serum periostin, YKL‐40, and osteopontin levels in pre‐school children with recurrent wheezing predict later development of asthma?

Güvenir

Büyüktiryaki

Celik

et al. 2020

Pediatric Allergy Immunology

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Background: Currently, there are no reliable clinical tools available for predicting asthma in preschool aged children with recurrent wheezing. The aim of this study was to evaluate the usefulness of serum periostin, YKL-40, and osteopontin biomarkers in wheezy preschool aged children for predicting the development of asthma in school ages. Methods: The study was prospectively conducted between 2011 and 2017. The clinical features of the preschool aged children with recurrent wheezing and the levels of serum periostin, YKL-40, and osteopontin were measured. The same participants were reevaluated in school-age period, and participants with asthma were identified. Relative risk (RR) for the development of asthma was analyzed. Results: Of the 197 preschool aged children with recurrent wheezing who were reevaluated in school-age years, 32% of them had asthma. Serum periostin, YKL-40, and osteopontin levels at admission could not predict participants who would have asthma symptoms in school-age years. The RR for continuing of asthma symptoms was higher in participants who had their first wheezing episode before 1 year of age, preterm birth, cesarean section delivery, prenatal smoking exposure, multi-trigger wheezing, parental asthma, modified asthma predictive index positivity, prophylactic vitamin D intake ≤ 12 months, breastfeeding time ≤ 12 month, and aeroallergen sensitivity [RR (95% CI) and P value

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Section: Discussionmentioning

confidence: 81%

Can serum periostin, YKL‐40, and osteopontin levels in pre‐school children with recurrent wheezing predict later development of asthma?

Güvenir

Büyüktiryaki

Celik

et al. 2020

Pediatric Allergy Immunology

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“…Obesity is associated with increased incidence of asthma [ 46 ] and poor symptom control [ 47 ]. The mechanisms behind the effect of obesity on asthma are not fully understood, but proposed processes include lung mechanics such as decreased lung volume [ 48 ] and increased systemic inflammation due to pro-inflammatory cytokines released from adipose tissue [ 49 ]. Obese individuals are less responsive to ICS than non-obese individuals [ 50 , 51 ], and this is possibly due to modifications in the glucocorticoid response pathways in obese asthmatics [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

How Frequently Is Asthma Objectively Demonstrated before Starting a Biologic? Quality Assessment of a Group Practice of Allergists and Immunologists

Dziewa

Craig

Al‐Shaikhly

2020

IJERPH

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Worldwide, asthma-related healthcare cost remains a major burden. Individuals with severe asthma account for 50% of that cost. Although they are expensive, biologics such as anti-IL5 and anti-IgE agents promise cost-effectiveness when judiciously used to decrease asthma-related hospitalization and the debilitating side effects of systemic corticosteroids. Before considering biologics to treat patients with asthma, current guidelines recommend confirmation of asthma and control of comorbid diseases. Diagnostic confirmation of asthma can be challenging among individuals with severe asthma. In this quality assessment study, we determined the frequency of objective asthma confirmation and addressing of comorbidities prior to starting biologics at a group practice of allergists and immunologists. We surveyed our specialty providers to understand habit(s) leading to the observed results. We identified 40 adult patients who started on biologic modifiers for asthma over the past 5 years. Only 58% of these patients had a proper diagnosis of asthma. Providers underutilized several diagnostic methods that may prove useful in confirming asthma diagnosis in this patient population. The factors contributing to poor asthma control were rarely addressed. A sense of urgency to initiate biologics was the primary reason for the observed results. Further interventions are needed to improve asthma diagnosis and management prior to the initiation of biologic therapeutics.

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“…The reason for this is seen in pro-inflammatory adipokines and proteins released from the adipose tissue in obese individuals. It is thought that these adipokines contribute to asthma and the hypersensitivity of the airways by inducing airway inflammation or increasing existing inflammation [15].…”

Section: Active Participation Of Mediators Of Adipose Tissue – Systemmentioning

confidence: 99%

“…For example, it has been shown that markers of metabolic inflammation, mainly in visceral adipose tissue, are significantly higher in obese patients with late-onset asthma compared with control subjects. While there is clear evidence of increased systemic inflammation in adults who are asthmatic-obese, there is conflicting evidence regarding systemic inflammation in children who are asthmatic-obese [1, 15].…”

Section: Active Participation Of Mediators Of Adipose Tissue – Systemmentioning

confidence: 99%

Obesity and asthma: risk, control and treatment

Marko¹,

Pawliczak²

2018

pdia

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Asthma and obesity are currently one of the most common diseases. Observing an increase in morbidity of obesity and asthma, it can be concluded that there is a link between these diseases. But the mechanism of this relation is not well known. Due to reduced movement in patients and treatment, asthma is conducive to obesity, and obesity can exacerbate the symptoms associated with asthma. Obesity can affect bronchial hyperresponsiveness. Increasing body fat in obese people leads to systemic inflammation and elevated serum levels of many proinflammatory cytokines (e.g. leptin) and anti-inflammatory ones (e.g. adiponectin) that can have a causal relationship to bronchial asthma, but human studies are ambiguous. Obese asthmatics are characterized by a phenotype: heavier asthma, worse response to treatment and control of asthma. It has been found that in obese people, weight loss reduces the severity of asthma symptoms, so in these patients, treatment should include weight control.

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Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients

Abstract: This is the first study to investigate levels of hs-CRP, NGAL, OPN, MMP-9, and 25(OH)-vitamin D in obese asthmatic children. Larger studies with sputum and BAL examinations are required to determine the potential of biomarkers for identifying inflammation in obese asthmatic children.

Cited by 11 publications

References 30 publications

Can serum periostin, YKL‐40, and osteopontin levels in pre‐school children with recurrent wheezing predict later development of asthma?

Can serum periostin, YKL‐40, and osteopontin levels in pre‐school children with recurrent wheezing predict later development of asthma?

How Frequently Is Asthma Objectively Demonstrated before Starting a Biologic? Quality Assessment of a Group Practice of Allergists and Immunologists

Obesity and asthma: risk, control and treatment

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