Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

Salvioli, Stefano; Basile, Maria Sofia; Bencivenga, Leonardo; Carrino, Sara; Conte, Maria; Damanti, Sarah; De Lorenzo, Rebecca; Fiorenzato, Eleonora; Gialluisi, Alessandro; Ingannato, Assunta; Antonini, Angelo; Baldini, Nicola; Capri, Miriam; Cenci, Simone; Iacoviello, Licia; Nacmias, Benedetta; Olivieri, Fabiola; Rengo, Giuseppe; Querini, Patrizia Rovere; Lattanzio, Fabrizia

doi:10.1016/j.arr.2023.102044

Cited by 15 publications

(5 citation statements)

References 338 publications

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“…Previous research has predominantly focused on understanding how aging impacts PD, with some studies illustrating a connection between DNAm-age acceleration and the age of PD onset ( Tang et al, 2022 ). However, there has been limited investigation into the influence of PD on DNAm age ( Salvioli et al, 2023 ). A case–control analysis revealed that PD patients exhibit a higher DNAm age based on different epigenetic clocks ( Horvath and Ritz, 2015 ; Paul et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study

Zhang,

Liu,

Pan

et al. 2023

Front. Neurosci.

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BackgroundAging is a significant risk factor for many neurodegenerative diseases and neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere length (TL), and epigenetic aging clock acceleration are commonly used biological aging proxy indicators. This study aims to comprehensively explore potential relationships between biological aging and neurodegenerative diseases and neurological tumors by integrating various biological aging proxy indicators, employing Mendelian randomization (MR) analysis.MethodsTwo-sample bidirectional MR analyses were conducted using genome-wide association study (GWAS) data. Summary statistics for various neurodegenerative diseases and neurological tumors, along with biological aging proxy indicators, were obtained from extensive meta-analyses of GWAS. Genetic single-nucleotide polymorphisms (SNPs) associated with the exposures were used as instrumental variables, assessing causal relationships between three neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis), two benign neurological tumors (vestibular schwannoma and meningioma), one malignant neurological tumor (glioma), and four biological aging indicators (frailty index, facial aging, TL, and epigenetic aging clock acceleration). Sensitivity analyses were also performed.ResultsOur analysis revealed that genetically predicted longer TL reduces the risk of Alzheimer’s disease but increases the risk of vestibular schwannoma and glioma (All Glioma, GBM, non-GBM). In addition, there is a suggestive causal relationship between some diseases (PD and GBM) and DNA methylation GrimAge acceleration. Causal relationships between biological aging proxy indicators and other neurodegenerative diseases and neurological tumors were not observed.ConclusionBuilding upon prior investigations into the causal relationships between telomeres and neurodegenerative diseases and neurological tumors, our study validates these findings using larger GWAS data and demonstrates, for the first time, that Parkinson’s disease and GBM may promote epigenetic age acceleration. Our research provides new insights and evidence into the causal relationships between biological aging and the risk of neurodegenerative diseases and neurological tumors.

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Section: Discussionmentioning

confidence: 99%

Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study

Zhang,

Liu,

Pan

et al. 2023

Front. Neurosci.

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“…The identification of a miRNA signature that can be associated with the differentiation process and is specific for each vascular district would open novel research directions for the future of artery-specific approaches. In this future perspective, blood-circulating miRNAs can be employed as diagnostic tools for risk stratification also in the elderly population [ 71 ] to identify patients at greater risk of cardiovascular mortality.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity and Differentiation of the Human Arterial Tree: Focus on microRNA Expression in Vascular Disease

Ciavarella,

Motta,

Capri

et al. 2024

Biomolecules

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Human arteries show structural and functional peculiarities according to the nutrient and oxygen needs of a specific vascular district. This architectural heterogeneity is reflected in the pathological setting of cardiovascular diseases (CVDs). Indeed, the responsiveness to cardiovascular risk factors, and the morphological and molecular patterns are discriminating factors among CVDs affecting different vascular beds. MicroRNAs (miRNAs) are endogenous regulators of gene expression and fine-tuners of vascular cell differentiation; thus, these non-coding RNAs can modulate arterial heterogeneity. The identification of an artery-specific miRNA signature would be promising in the therapy of CVDs, especially in patients who are frail and elderly. In the present review, we will provide a concise description of the arterial tree heterogeneity on a structural and cellular basis, mainly in the pathological context. Secondly, we will address the miRNA potential as crucial mediators of arterial heterogeneity, focusing on the abdominal aorta and femoral artery, with the final goal of strengthening the search for more targeted therapies in CVDs and stratification approaches in patients who are frail and elderly.

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“…Frailty is a prevalent syndrome of old age that is strongly associated with disability, mortality, and hospitalization [14][15][16]. However, the underlying mechanisms of the frailty still need to be better understood [17][18][19][20]. In recent years, researchers have generally recognized the link between frailty and a wide range of diseases.…”

Section: Discussionmentioning

confidence: 99%

Association between Frailty and Senescence from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study

li,

Xie,

Tian

et al. 2023

Preprint

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Background Aging is an inevitable phenomenon of biological processes, and frailty, one of its key symptoms, usually reflects a decline in the body's functional and adaptive capacity. In this study, we aimed to investigate the association between frailty index (FI) and phenotypic age using quantitative measures. Herein, a cross-sectional study in a U.S. population reinforces current clinical knowledge that frailty promotes accelerated aging in phenotypic age. Methods In this cross-sectional study, data from the National Health and Nutrition Examination Survey (NHANES) were utilized, encompassing 11,918 participants aged 20 years and older. The analyses employed multiple logistic regression and restricted cubic splines (RCS). Additionally, subgroup analyses stratified by covariates were performed. Results This study included 11,918 adult participants with complete data. After adjusting for all confounding factors, a significant positive correlation was observed between FI and phenotypic age [2.04 (1.89, 2.18)], indicating that for every 0.1 increase in FI score, the phenotypic age increased by 2.04 years. Further subgroup analysis demonstrated that this association was significant only in some subgroups. Conclusion We observed a correlation between FI and the accelerated aging represented by phenotypic age. Our findings warrant further confirmation in future, more extensive prospective studies.

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Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

Cited by 15 publications

References 338 publications

Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study

Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study

Heterogeneity and Differentiation of the Human Arterial Tree: Focus on microRNA Expression in Vascular Disease

Association between Frailty and Senescence from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study

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