Biomarkers intersection between depression, diabetes, and cognitive impairment

Diniz, Breno S.

doi:10.1017/s1041610219001741

Cited by 1 publication

(1 citation statement)

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“…Nonetheless, the present meta-analysis indicates that high HbA1c levels may be a good indicator for clinicians to explore the presence of depression in individuals with T2DM. Detecting symptoms of depression could be very useful in medical practice, as people living with depressive symptoms have emotional difficulties that could interfere with getting used to having diabetes and following health advice [ 44 , 45 ]. Additionally, individuals with T2DM and depression may have high levels of stress daily, which could lead to difficulties in manning an appropriate diet, adequate exercise, and adherence to treatment among other daily activities that are necessary to have good glycemic control [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Levels of HbA1c in Individuals with Type 2 Diabetes and Depression: A Meta-Analysis of 34 Studies with 68,398 Participants

et al. 2022

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Glycosylated hemoglobin is used to diagnose type 2 diabetes mellitus and assess metabolic control. Depression itself has been associated with high levels of HbA1c in individuals with T2DM. The association between diabetes and depression suggests the usefulness of determining HbA1c as a biological marker of depressive symptoms. The aim of this study was to determine HbA1c levels in individuals with T2DM with vs. without depression. Additionally, we analyzed the influence of pharmacological treatments, time of evolution, and complications of disease. We performed a literature search in different databases published up to January 2020. A total of 34 articles were included. Our results showed that individuals with T2DM with depression showed increased levels of HbA1c in comparison to individuals with T2DM without depression (d = 0.18, 95% CI: 0.12–0.29, p(Z) < 0.001; I2 = 85.00). We also found that HbA1c levels remained elevated in individuals with T2DM with depression who were taking hypoglycemic drugs (d = 0.20 95% CI: 0.11–0.30, p(Z) < 0.001; I2 = 86.80), in individuals with less than 10 years of evolution (d = 0.17 95% CI: 0.09–0.26, p(Z) = 0.001; I2 = 66.03) and in individuals with complications of the disease (d = 0.17, 95% CI: 0.07–0.26, p(Z) < 0.001; I2 = 58.41). Our results show that HbA1c levels in individuals with T2DM with depression are significantly increased compared to controls with T2DM without depression. Additionally, these levels remained elevated in individuals who were taking hypoglycemic drugs, those with less than 10 years of disease evolution, and those with complications related to diabetes. It is necessary to examine the existence of a diabetes–HbA1c–depression connection.

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Section: Discussionmentioning

confidence: 99%