Biomarkers in urine and stool

Costello, Ben de Lacy; Gould, Oliver; Ratcliffe, Norman M.

doi:10.1016/b978-0-12-819967-1.00024-4

Cited by 2 publications

(4 citation statements)

References 69 publications

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“…It is known that many types of pathologies are characterized by a certain odor and, consequently, by a set of volatile substances. Many substances that are metabolites in pathogenic processes are found in human secretions [ 14 , 15 ]. Therefore, volatile markers were identified in the EGP of urine samples according to identification parameters calculated by Equations (1)–(4).…”

Section: Discussionmentioning

confidence: 99%

“…The choice of sensors for an array is influenced by their high sensitivity to various classes of volatile substances, including volatile biomarkers of diseases in the urine [ 14 , 15 , 16 ]. Films of 18C6, Tween were chosen for the detection of carboxylic and hydroxy acids [ 47 , 48 ], and MCNT, BCB, MR for ammonia and amines [ 49 , 50 , 51 ].…”

Section: Methodsmentioning

confidence: 99%

“…The volatile compounds of urine change more significantly along with the proteome during the development of the disease. Consequently, studies of the gas composition of urine were carried out [ 13 , 14 ], and methods for determining volatile biomarkers in urine were proposed [ 15 , 16 ]. Bacterial metabolites secreted on nutrient media have also been studied [ 17 , 18 ], including volatile compounds secreted during infection of tissues [ 17 ] and exudates [ 19 ], lesion by Staphylococcus aureus [ 20 ], respiratory and gastrointestinal diseases [ 21 ], bacteriuria [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Кучменко

Menzhulina

Шуба

2022

Sensors

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Currently, antibiotics are often prescribed to children without reason due to the inability to quickly establish the presence of a bacterial etiology of the disease. One way to obtain additional diagnostic information quickly is to study the volatile metabolome of biosamples using arrays of sensors. The goal of this work was to assess the possibility of using an array of chemical sensors with various sensitive coatings to determine the presence of a bacterial infection in children by analyzing the equilibrium gas phase (EGP) of urine samples. The EGP of 90 urine samples from children with and without a bacterial infection (urinary tract infection, soft tissue infection) was studied on the “MAG-8” device with seven piezoelectric sensors in a hospital. General urine analysis with sediment microscopy was performed using a Uriscan Pro analyzer and using an Olympus CX31 microscope. After surgical removal of the source of inflammation, the microbiological studies of the biomaterial were performed to determine the presence and type of the pathogen. The most informative output data of an array of sensors have been established for diagnosing bacterial pathology. Regression models were built to predict the presence of a bacterial infection in children with an error of no more than 15%. An indicator of infection is proposed to predict the presence of a bacterial infection in children with a high sensitivity of 96%.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Кучменко

Menzhulina

Шуба

2022

Sensors

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“…However even among the three, urine is considered easier and more pleasant to sample than faeces and breath is even easier to give from a patient’s point of view. 10 Therefore targeting VOCs as non-invasive biomarkers of IBD is advantageous as compared with other potential biomarkers such as methylated DNA or microRNAs 11 , 12 and should be more acceptable to patients. This is essential when looking for a biomarker for potential use in disease screening and disease monitoring—it must be relatively cheap, non-invasive, and acceptable to patients, among other characteristics.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Utility of Volatile Organic Compounds in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Krishnamoorthy

Chandrapalan

Ahmed

et al. 2023

Journal of Crohn's and Colitis

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Background Volatile organic compounds (VOCs) show promise as potential biomarkers of for ulcerative colitis and Crohn’s disease, two chronic idiopathic gastrointestinal disorders with diagnostic and management challenges. Non-invasive biomarkers aid early diagnosis and management. In this study we review studies of diagnostic accuracy of VOCs in inflammatory bowel disease. Methods A systematic search was carried out on the Pubmed and Scopus databases; with sixteen studies reviewed and meta-analysis carried out on ten. Results Meta analysis of 696 IBD cases against 605 controls revealed a pooled sensitivity and specificity of 87% (95% CI, 0.79 - 0.92) and 83% (95% CI, 0.73 - 0.90) respectively. AUC was 0.92. Conclusion VOCs perform very well as non-invasive biomarkers of IBD; with much scope for future improvement and research.

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Biomarkers in urine and stool

Cited by 2 publications

References 69 publications

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

Noninvasive Detection of Bacterial Infection in Children Using Piezoelectric E-Nose

The Diagnostic Utility of Volatile Organic Compounds in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

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