Biomarkers in the Occurrence and Development of Pterygium

He, Siying; Wu, Zhaoxia

doi:10.1159/000523878

Cited by 7 publications

(2 citation statements)

References 70 publications

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“…Pterygium is a chronic inflammatory disease caused by external stimuli and is a common disease in ophthalmology [ 1 ]. Its occurrence and development are ascribed to external environmental stimuli or genetics [ 2 ]. Corneal invasion can result in changes in corneal morphology or refractive abnormalities [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Acupoint Massage plus Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Limbal Stem Cell Transplantation on Visual Quality, Corneal Refraction, and Aesthetic Outcome in Patients with Pterygium

Zhang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the clinical study of acupoint massage combined with recombinant bovine basic fibroblast growth factor (rbFGF) ophthalmic gel combined with limbal stem cell transplantation on visual quality, corneal refraction, and aesthetic outcome in patients with pterygium. Methods. Sixty patients with pterygium treated in People’s Hospital of Lujiang County from March 2018 to May 2021 were randomized into the control group and the research group by the random number table method, with 30 cases in each group. The control group received rbFGF plus limbal stem cell transplantation. The research group was treated with acupoint massage additionally. Results. The total clinical effective rate in the study group was higher than that in the control group ( P < 0.05 ); after treatment, the modulation transfer function (MTF) cutoff and Strehl ratio (SR) levels in the study group were significantly higher than those in the control group, and the tear film-related objective scatter index (TF-OSI) was significantly lower than that in the control group ( P < 0.05 ); corneal horizontal curvature and corneal vertical curvature in the study group after treatment were significantly higher than those in the control group, and corneal astigmatism degree (CAD) levels were significantly lower than those in the control group ( P < 0.05 ); the levels of the break-up time (BUT) and Schirmer test (SIT) in the study group were significantly higher after treatment, compared with the control group ( P < 0.05 ); and the incidence of adverse manifestations in the study group was significantly lower than that in the control group ( P < 0.05 ). Conclusion. Acupoint massage combined with rbFGF ophthalmic gel combined with limbal stem cell transplantation is effective in clinical treatment of pterygium.

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Section: Introductionmentioning

confidence: 99%

Acupoint Massage plus Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Limbal Stem Cell Transplantation on Visual Quality, Corneal Refraction, and Aesthetic Outcome in Patients with Pterygium

Zhang

2022

Evidence-Based Complementary and Alternative Medicine

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“…There are varying opinions on how to manage postoperative ocular surface recovery and recurrence of pterygium, including drug intervention 10 and surgical techniques 11 that cause minimal damage to the ocular surface. Nevertheless, there is currently a need for a straightforward and efficient diagnostic tool in clinical practice to ascertain pterygium's ocular surface inflammatory status 12 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of lymphotoxin-alpha in pterygium and diagnostic value in active and inactive pterygium states

Lan,

Fang,

Zhong

et al. 2024

Sci Rep

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To explore the correlation between tear LT-a, pterygium status, and dry eye indicators. We established a diagnostic model to evaluate active pterygium. A retrospective study was conducted between June 2021 and June 2023 on 172 patients, comprising 108 men and 64 women. The study analyzed LT-a and various ocular parameters in all participants. The data was collected using Excel software and analyzed using SPSS 25.0 statistical software and Medcalc. We made a nomogram diagnostic model to different diagnosed the state of pterygium. This study found that pterygium has progressive eye surface damage during the active state. There was no significant difference in dry eye indicators between the two groups. However, the concentration of LT-a in the active group was significantly lower than that in the inactive group (P < 0.001). We observed that increased pterygium grade corresponded to a worse ocular surface condition. In addition, LT-a was significantly positively correlated with disease duration, but negatively correlated with age, pterygium size, active pterygium state, and LLT value. The optimal intercept value for evaluating active pterygium in Lt-a was ≤ 0.49 dg/ml. We screened three variables for evaluating active pterygium through Single and Multiple regression analysis: LT-a grading, pterygium size, and congestion score. Finally, we made a reliable diagnostic nomogram model. Pterygium development triggers immune inflammation. Our model based on LT-a identifies active pterygium for personalized treatment options and new research directions.

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The effect on m6A methylation writer complex by the reduced MATR3 in pterygium

Guo,

Han

2023

Acta Histochemica

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Biomarkers in the Occurrence and Development of Pterygium

Cited by 7 publications

References 70 publications

Acupoint Massage plus Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Limbal Stem Cell Transplantation on Visual Quality, Corneal Refraction, and Aesthetic Outcome in Patients with Pterygium

Acupoint Massage plus Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Limbal Stem Cell Transplantation on Visual Quality, Corneal Refraction, and Aesthetic Outcome in Patients with Pterygium

Evaluation of lymphotoxin-alpha in pterygium and diagnostic value in active and inactive pterygium states

The effect on m6A methylation writer complex by the reduced MATR3 in pterygium

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