Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Feklicheva, Inna; Boks, Marco P.; Kloet, E. R. de; Chipeeva, Nadezda; Maslennikova, Ekaterina; Pashkov, Anton; Korobova, Svetlana; Komelkova, Maria; Kuznetsova, Yu. A.; Platkovski, Pavel; Mamonova, M. V.; Сидоренко, О.В.; Vasilenko, T F; Tseilikman, Olga; Tseĭlikman, Vadim

doi:10.1016/j.jpsychires.2021.11.032

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…Feklicheva, et al (2021) 9 showed that no significant differences were present between the studied groups in the levels of the thyroid hormones and thyroid stimulating hormone, which casts doubt on their significance as a biomarker at least in this group of military. Mean levels of T3 (triiodothyronine), T4 (thyroxine) and TSH (thyroid-stimulating hormone) did not differ between groups (F (2, 85) = 1.15, p = 0.321; F (2, 85) = 1.92, p = 0.153; F (2, 85) = 1.3, p = 0.277, respectively).…”

Section: Resultsmentioning

confidence: 93%

Association of Thyroid Function and Post Traumatic Stress Disorder: A Systematic Review

Prameswari,

Azhari

2023

JARMHS

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Background: Numerous studies conducted over the last few decades have shown a negative correlation between post-traumatic stress disorder PTSD and physical health and wellbeing. Thyroid dysfunction may be related to a variety of mental disorders, including PTSD. However, it is still debatable. The aim: This study aims to investigate association between thyroid function and post-traumatic stress disorder. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up to date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Results: In the PubMed database, the results of our search brought up 42 articles, whereas the results of our search on ScienceDirect brought up 163 articles. The results of the search conducted by title screening yielded a total 15 articles for PubMed and 10 articles for ScienceDirect. We compiled a total of 14 papers, 11 of which came from PubMed and 3 of which came from ScienceDirect. We excluded 3 review articles, 3 duplicate articles, 1 animal study, and 2 articles having ineligible outcomes data. In the end, we included five research that met the criteria. Conclusion: PTSD may alter thyroid function but there is scanty evidence regarding their relationship.

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Section: Resultsmentioning

confidence: 93%

Association of Thyroid Function and Post Traumatic Stress Disorder: A Systematic Review

Prameswari,

Azhari

2023

JARMHS

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“…Testosterone is synthesized and secreted by testicular Leydig cells and the adrenal cortex and is regulated by the hypothalamic-pituitary-gonadal axis [ 57 ]. Testosterone plays irreplaceable roles in the growth and development of the human body, maintaining musculoskeletal homeostasis and regulating post-traumatic stress disorder [ 58 – 60 ]. Although little literature reports their direct relationships with trauma, the information above seems to imply that higher levels of isoleucine and testosterone are beneficial for patients with trauma.…”

Section: Discussionmentioning

confidence: 99%

Integrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy

Zheng,

Wang,

Cong

et al. 2024

Thrombosis J

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Background Routine coagulation tests are not widely accepted diagnostic criteria of trauma-induced hypercoagulopathy (TIH) due to insensitivity. Lymphatic vessels drain approximately 10% of the interstitial fluid into the lymphatic system and form lymph. Subjective The purpose of this study was to identify the potential lymph biomarkers for TIH. Methods Eighteen male Sprague-Dawley rats were randomly assigned to the sham (non-fractured rats with sham surgery and vehicle treatment), the VEH (fractured rats with vehicle treatment) and the CLO (fractured rats with clopidogrel treatment) group. Thoracic duct lymph was obtained to perform proteomics and untargeted metabolomics. Results A total of 1207 proteins and 16,695 metabolites were identified. The top 5 GO terms of lymph proteomics indicated that oxidative stress and innate immunity were closely associated with TIH and antithrombotic therapy. The top 5 GO terms of lymph metabolomics showed that homocystine and lysophosphatidylcholine were the differential expressed metabolites (DEMs) between the sham and VEH groups, while cholic acid, docosahexaenoic acid, N1-Methyl-2-pyridone-5-carboxamide, isoleucine and testosterone are the DEMs between the VEH and CLO group. Conclusions This study presents the first proteomic and metabolomic profiling of lymph after TIH and antithrombotic therapy, and predicts the possible lymph biomarkers for TIH.

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“…Elzinga B.M. et al [ 62 ] assessed cortisol responsivity to traumatic recollections among males with childhood abuse-related PTSD. PTSD patients were found to have higher cortisol responses to stress in comparison to those of controls.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress

Ogłodek

2022

IJERPH

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Background: Stress is a common response to many environmental adversities. However, once dysregulated, this reaction can lead to psychiatric illnesses, such as post-traumatic stress disorder (PTSD). Individuals can develop PTSD after exposure to traumatic events, severely affecting their quality of life. Nevertheless, not all individuals exposed to stress will develop psychiatric disorders, provided they show enhanced stress-resilience mechanisms that enable them to successfully adapt to stressful situations and thus avoid developing a persistent psychopathology. Methods: The study involved 93 participants. Of them, 62 comprised a study group and 31 comprised a control group. The aim of the study was to assess serotonin, cortisol and tryptophan concentration levels in subjects with PTSD (stress-susceptible; PTSD-SS) and in healthy individuals (stress-resilient; PTSD-SR), who had experienced a traumatic event but fully recovered after the trauma. The subjects were between 18 and 50 years of age (mean 35.56 ± 8.26 years). The serum concentration levels of serotonin, cortisol and tryptophan were measured with an ELISA kit. Results: It was found that the serotonin, tryptophan and cortisol concentration levels were consistent with the features of both PTSD-SR and PTSD-SS patients. It was reported that the mean cortisol concentration levels increased more significantly in the PTSD-SS group than in the PTSD-SR group, versus those in the control group. Similarly, the PTSD-SS group was found to show a larger decrease in the mean serotonin concentration levels than the PTSD-SR group, versus those in the control group. No significant changes were found in the tryptophan concentration levels between the study groups, versus those in the control group. Conclusions: These findings can be useful when attempting to improve resilience in individuals using neuropharmacological methods. However, it is necessary to conduct more cross-sectional studies that would address different types of negative stress to find out whether they share common pathways.

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Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Cited by 7 publications

References 40 publications

Association of Thyroid Function and Post Traumatic Stress Disorder: A Systematic Review

Association of Thyroid Function and Post Traumatic Stress Disorder: A Systematic Review

Integrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy

Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress

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